A5069037211- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Plant Molecular Biology Research
- RNA Research and Splicing
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Immune Response and Inflammation
- Genomics and Chromatin Dynamics
- Photosynthetic Processes and Mechanisms
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Plant Reproductive Biology
- Pharmacological Effects of Natural Compounds
- Nuclear Structure and Function
- Crystallography and molecular interactions
Henan University of Technology
2025
Peking University
2022-2023
Center for Life Sciences
2022-2023
Beijing National Laboratory for Molecular Sciences
2023
Fertilization of an egg by multiple sperm (polyspermy) leads to lethal genome imbalance and chromosome segregation defects. In
Biomolecular condensates formed by phase separation are involved in many cellular processes. Dysfunctional or abnormal closely associated with neurodegenerative diseases, cancer and other diseases. Small molecules can effectively regulate protein modulating the formation, dissociation, size material properties of condensates. Discovery small to provides chemical probes for deciphering underlying mechanism potential novel treatments condensate-related Here we review advances molecule...
Biomacromolecules often form condensates to function in cells. VRN1 is a transcriptional repressor that plays key role plant vernalization. Containing two DNA-binding domains connected by an intrinsically disordered linker (IDL), was shown undergo liquid-like phase separation with DNA, and the length charge pattern of IDL play major regulatory roles. However, underlying mechanism remains elusive. Using polymer chain model lattice-based Monte-Carlo simulations, we comprehensively investigated...