A5101910235- Plant tissue culture and regeneration
- Pulmonary Hypertension Research and Treatments
- Banana Cultivation and Research
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- MicroRNA in disease regulation
- Nutrition, Genetics, and Disease
- Natural Products and Biological Research
- Aortic aneurysm repair treatments
- Metastasis and carcinoma case studies
- Medical Device Sterilization and Disinfection
- Click Chemistry and Applications
- Adolescent Sexual and Reproductive Health
- Gynecological conditions and treatments
- Chromosomal and Genetic Variations
- Livestock and Poultry Management
- Seed Germination and Physiology
- Urologic and reproductive health conditions
- Botany, Ecology, and Taxonomy Studies
- Protein Hydrolysis and Bioactive Peptides
- Gastric Cancer Management and Outcomes
- Plant Reproductive Biology
- Cardiac Valve Diseases and Treatments
- Muscle metabolism and nutrition
University of Michigan
2018-2021
Washtenaw Community College
2021
Dysregulation of microRNA (miRNA) expression has been linked to many human diseases; however, because the challenges associated with RNA-targeted drug discovery, additional approaches are needed for probing miRNA biology. The emerging regulatory role miRNA-binding proteins in maturation presents such an alternative strategy. Exploiting our laboratory's click chemistry-based high-throughput screening (HTS) technology, catalytic enzyme-linked chemistry assay or cat-ELCCA, we have designed a...
In a high-throughput screening campaign, we recently discovered the rRNA-binding tetracyclines, methacycline and meclocycline, as inhibitors of Dicer-mediated processing microRNAs. Herein, describe our biophysical biochemical characterization these compounds. Interestingly, although direct, albeit weak, binding to pre-microRNA hairpins was observed, inhibitory activity compounds not due RNA binding. Through additional chemical studies, revealed that metal chelation likely plays principle...
MicroRNAs (miRNAs) are a family of small noncoding RNAs that regulate gene expression. Due to their important activity in the fine-tuning protein translation, abnormal expression miRNAs has been linked many human diseases, making targeting attractive as novel therapeutic strategy. Accordingly, researchers have heavily engaged discovery molecule modulators miRNAs. With an interest identification new chemical space for miRNAs, we developed high-throughput screening (HTS) technology, catalytic...
La infeccion vulvovaginal (IVV) es una causa frecuente de consulta ginecologica en adolescentes siendo Vaginosis bacteriana, candidiasis y trichomoniasis sus etiologias mas frecuentes. Estudios anteriores chilenas arrojan cifras disimiles respecto a la contribucion cada las anteriores. Nuestro objetivo fue identificar frecuentes IVV sintomaticas que consultaron un Centro atencion adolescente del area Norte Santiago. Se tomaron muestras flujo vaginal 100 fueron analizadas mediante Gram...
Introducción: La estratificación del riesgo de complicaciones mayores (incluyendo mortalidad) es, en la actualidad, estrategia clínica fundamental para toma decisiones terapéuticas pacientes con hipertensión arterial pulmonar.Sin embargo, es llamativo que mayoría se agrupan categoría intermedia, tanto el momento diagnóstico como seguimiento, lo cual hace relevante y necesario mejorar discriminación las opciones los intermedio.Objetivo: Definir una serie recomendaciones sobre propia...
El consumo de proteína y especialmente aminoácidos esenciales juega un papel fundamental en la dieta, ya que suple las necesidades nitrógeno del organismo favorece el mantenimiento estructuras corporales. En los últimos años, nutrición tecnología alimentos están experimentando una profunda transformación debido al desarrollo concepto funcionales nutracéuticos. Tanto proteínas como péptidos bioactivos cobrando gran importancia que, además su nutricional por ser fuente aminoácidos, son capaces...
La automatizacion de la produccion plantas con el empleo Biorreactores Inmersion Temporal (BIT) constituye una herramienta eficaz para propagacion in vitro cual se elevan los coeficientes multiplicacion y aumenta calidad del material propagado. Algunos factores que influyen en este proceso son las caracteristicas explantes emplean inocular BIT, manipulacion mismos su estado fisiologico. Estos, aparejados a indicadores eficiencia sistema, elementos tener cuenta estudio morfogenesis cultivos...
Introduction: stratification of risk for major complications (including mortality) is the current fundamental clinical strategy making therapeutic decisions in patients with pulmonary arterial hypertension.However, it noticeable that most are grouped intermediate category both at time diagnosis and during follow-up, highlighting relevance necessity improving discrimination options risk.Objective: to define a series recommendations on proper subclassification, treatment adult hypertension...