A5009950858- Estrogen and related hormone effects
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Hormonal and reproductive studies
- Proteoglycans and glycosaminoglycans research
- Sperm and Testicular Function
- Carbon and Quantum Dots Applications
- Prostate Cancer Treatment and Research
- 14-3-3 protein interactions
- PI3K/AKT/mTOR signaling in cancer
- Reproductive biology and impacts on aquatic species
- Photochromic and Fluorescence Chemistry
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Fibroblast Growth Factor Research
- Click Chemistry and Applications
- Neuroblastoma Research and Treatments
- Multiple Myeloma Research and Treatments
- Retinoids in leukemia and cellular processes
- PARP inhibition in cancer therapy
Nantong University
2020-2024
Mayo Clinic
2022-2023
WinnMed
2022-2023
China Pharmaceutical University
2017
Abstract The HER2 receptor modulates downstream signaling by forming homodimers and heterodimers with other members of the HER family. For patients HER2-positive breast cancer, Trastuzumab, an anti-HER2 monoclonal antibody as first-line therapy has shown significant survival benefits. However, development acquired resistance to Trastuzumab continues be a obstacle. TNF receptor-associated factor 4 (TRAF4) upregulation was discovered associated worse clinical outcome. Here we identified TRAF4...
Mild testicular hyperthermia by the photothermal effect of gold nanorods could realize controllable male contraception. However, associated limitations, such as administration and infrared laser inflicting severe pain, nondegradability nanoparticles potentially causing toxicity, have restricted further clinical application. Inspired excellent physicochemical properties iron oxide (IONPs), finding that injection PEG-coated IONPs with a diameter 50 nm (PEG@Fe3O4-50) following an alternating...
Abstract Androgen receptor (AR) is expressed in 80% to 90% of estrogen α–positive (ER+) breast cancers. Accumulated evidence has shown that AR a tumor suppressor and its expression associated with improved prognosis ER+ cancer. However, both selective agonist (RAD140) an inhibitor (enzalutamide, ENZ) have therapeutic effect on cancer, so the potential for clinical application AR-targeting therapy cancer still dispute. In this study, we evaluated efficacy ENZ RAD140 vivo vitro AR+/ER+ models,...
Approximately one‐third of patients with metastatic castration‐resistant prostate cancer (CRPC) exhibited primary abiraterone resistance. To identify alternative treatment for nonresponders, we performed drug discovery analyses using the L1000 database differentially expressed genes identified in tumor biopsies and patient‐derived xenograft (PDX) tumors between responders nonresponders enrolled PROMOTE trial. This approach 3 drugs, including topoisomerase II (TOP2) inhibitor mitoxantrone,...
A photocontrollable biocatalyst was rationally designed by site-specifically linking a photoswitchable azobenzene derivative to the only cysteine residue in heparinase III mutant (K130C). Upon photoswitch, enzymatic degradation of heparin could be artificially controlled produce low molecular weight with more uniform and an increase anticoagulant activity.
Context The swim bladder of the croceine croaker is believed to have a therapeutic effect on various diseases. However, there no research about its mammalian spermatogenesis.Objective We investigated peptides (SBPs) busulfan-induced oligoasthenospermia in mice.Materials and methods first extracted SBP from protein hydrolysate bladder, then five groups ICR male mice were randomly assigned: control, control + 60 mg/kg, busulfan, busulfan 30 mg/kg mg/kg. Mice received bilateral intratesticular...
Mild testicular hyperthermia holds promise as a contraceptive approach. However, the great challenge lies in developing well-tolerated and highly targeted methods for hyperthermia. Here, we engineered dual-targeted casein (CN) coated magnetic iron oxide nanoparticles oral thermal agents male contraception. The core Fe3O4, facilitating targeting hyperthermia, was conjugated with anti-luteinizing hormone receptor (anti-LHR) by initial H2N-PEG-NH2 modification then CN layer-by-layer fashion...
Glycine is the simplest amino acid in living organisms and plays important roles biology medicine. However, few biosensors for glycine sensing have been reported. Herein, we present a facile strategy to construct dopamine-modified AuCu bimetallic nanoclusters (denoted as NC–DA) charge transfer-based highly sensitive sensing. The NCs stabilized by bovine serum albumin (BSA) exhibited fluorescence maximum at 400 nm. Because of high affinity BSA dopamine (DA), surface was modified with DA...
Poly(ADP-ribose) (PAR) polymerase inhibitors (PARPi) either have been approved or being tested in the clinic for treatment of a variety cancers with homologous recombination deficiency (HRD). However, cancer cells can develop resistance to PARPi drugs through various mechanisms, and new biomarkers combination therapeutic strategies need be developed support personalized treatment. In this study, genome-wide CRISPR screen was performed prostate cell line 3D culture condition which identified...
Abstract Glycosaminoglycans (GAG) lyases are useful biocatalysts for the preparation of oligosaccharides, but their substrate spectra limited to same family. Thus, degradation activity across families GAG is advantageous and desirable various applications. In this study, residue Lys130 at entrance monomeric heparinase III from Pedobacter heparinus ATCC 13125 was replaced by cysteine, resulting mutant K130C showed novel catalytic in degrading hyaluronic acid without affecting its native...
The cytochromes P450 (CYPs) represent a large gene superfamily that plays an important role in the metabolism of both exogenous and endogenous compounds. We have reported testis-specific Y-encoded-like proteins (TSPYLs) are novel CYP transcriptional regulators. However, little is known mechanism(s) by which TSPYLs regulate expression or functional consequences regulation. TSPYL family includes six members, TSPYL1 to TSPYL6. TSPYL3 pseudogene, TSPYL5 only regulates CYP19A1, TSPYL6 expressed...
Abstract The sensitive determination of multiple heavy metal ions and toxic anions is important in biological environmental fields. Here we report a facile strategy to construct multifunctional chemosensor for the detection Hg 2+ , <?CDATA ${{{\rm{NO}}}_{2}}^{-}$?> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:msup> <mml:msub> <mml:mrow> <mml:mi mathvariant="normal">NO</mml:mi> </mml:mrow> <mml:mn>2</mml:mn> </mml:msub> <mml:mo>−</mml:mo> </mml:msup>...
Here, we report glutathione-protected water-soluble copper nanoclusters (Cu8 NCs) with excellent properties of high stability, large Stokes shift, and low toxicity. The molecular formula structure the Cu8 NCs were confirmed through good agreement between spectroscopic results theoretical calculations. origin optical chemical stability was determined natural bond orbital analysis combined time-dependent density functional theory It found that fluorescence emission quantum yields could be...
TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors' transduction to downstream pathways and exert multifaceted roles pathways, cell survival, carcinogenesis. The 13-cis-retinoic acid (RA), an active metabolite of vitamin A, exhibits anti-cancer properties, but the development retinoic resistance poses challenge clinical application. This study aimed investigate relationship between TRAFs sensitivity various...
<div>Abstract<p>Androgen receptor (AR) is expressed in 80% to 90% of estrogen α–positive (ER<sup>+</sup>) breast cancers. Accumulated evidence has shown that AR a tumor suppressor and its expression associated with improved prognosis ER<sup>+</sup> cancer. However, both selective agonist (RAD140) an inhibitor (enzalutamide, ENZ) have therapeutic effect on cancer, so the potential for clinical application AR-targeting therapy cancer still dispute. In this...
<p>Figure S1-9</p>
<div>Abstract<p>Androgen receptor (AR) is expressed in 80% to 90% of estrogen α–positive (ER<sup>+</sup>) breast cancers. Accumulated evidence has shown that AR a tumor suppressor and its expression associated with improved prognosis ER<sup>+</sup> cancer. However, both selective agonist (RAD140) an inhibitor (enzalutamide, ENZ) have therapeutic effect on cancer, so the potential for clinical application AR-targeting therapy cancer still dispute. In this...
<p>Table S1-6</p>
<p>Table S1-6</p>
<p>Figure S1-9</p>
The accurate determination of testosterone is greatly significant. However, the few existing detection methods lack high sensitivity and convenience. Ratiometric fluorescent probes have become attractive tools for biochemical sensing due to its visual-detection self-calibration function. Herein, we developed a dual-emission ratiometric method based on aggregation-induced emission (AIE) gold nanoclusters (Au NCs) without conjugating any fluorophores. Au NCs stabilized by glutathione (GSH)...