A5079219575- Hemophilia Treatment and Research
- Blood donation and transfusion practices
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Hemoglobinopathies and Related Disorders
- Chronic Myeloid Leukemia Treatments
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemostasis and retained surgical items
- Organ Donation and Transplantation
- COVID-19 Clinical Research Studies
- Blood properties and coagulation
- Sepsis Diagnosis and Treatment
- Biomedical Ethics and Regulation
- Chronic Lymphocytic Leukemia Research
- Pluripotent Stem Cells Research
- Renal function and acid-base balance
- Cancer-related gene regulation
- Liver Disease Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
The University of Western Australia
2015-2024
Royal North Shore Hospital
2020
Queen Elizabeth II Medical Centre
2008-2019
Haemophilia Foundation Australia
2017
Kedrion (Italy)
2016
Australian National University
2012-2015
National Institute of Neurological Disorders and Stroke
2014
Patient-Centered Outcomes Research Institute
2014
National Heart Lung and Blood Institute
2014
Research Network (United States)
2014
Jean-Pierre Allain and colleagues argue that, while unintended, the foreign aid provided for blood transfusion services in sub-Saharan Africa has resulted serious negative outcomes, which requires reflection rethinking.
Summary. The effect of replacement therapy has significantly improved the morbidity and mortality people with haemophilia A in high income countries, a recent socio‐economic development as availability safe concentrates been matched by willingness for their provision through reimbursement. In developing world, however, this state not achieved, primarily because low visibility coupled its expense, leading to inadequate treatment sequelae severe pain, joint deformities, arthropathy,...
BACKGROUND: There are no current estimates of the residual risks transmission by blood hepatitis B virus (HBV) or C (HCV) and human immunodeficiency (HIV) in China. Such an essential prerequisite to monitoring improving transfusion safety as well supporting evidence based assessment value implementing new screening interventions. STUDY DESIGN AND METHODS: Viral data for donors from Shenzhen, China, period 2001 2004, were retrospectively analyzed. The applied a published model estimate risk...
Prophylaxis has been established as the treatment of choice in children with haemophilia and its continuation into adult years shown to decrease morbidity throughout life. The cost factor therapy made option questionable cost-effectiveness studies. role prophylaxis pharmacokinetic dosage tolerization against inhibitor formation were used model utility vs. on-demand (OD) over a lifetime horizon severe A. was applied single provider national health system exemplified by United Kingdom's...
Lovexair is a non-profit organization dedicated to the care, support and guidance of people with respiratory pathologies healthcare professionals. has developed HappyAir Community, an ecosystem clinical, educational social resources for comprehensive patient well-being better quality life. We report on outcomes events held in two Latin American countries (Colombia Mexico) late 2023, launching project these communities through assessing demographics, clinical risk factors diseases patients...
Chronic respiratory diseases such as asthma and COPD are prevalent in Latin America, yet diagnostic management challenges persist. This study assessed the demographics, clinical characteristics, risk factors of patients with disorders Colombia Mexico. A total 103 were evaluated using spirometry, exhaled nitric oxide (FeNO), Assessment Test (CAT), Asthma Control (ACT). Only 22% participants showed abnormal spirometry despite a reported prevalence 39%. Conversely, FeNO abnormalities closely...
Abstract. The effect of replacing a standard citrate anticoagulant with one containing half the amount on in vitro properties components prepared from blood donations was investigated. This resulted significant improvement factor VIII stability such that there little loss during overnight storage, and this reflected yield cryoprecipitate. quality cellular red cell units stored up to 35 days or platelet concentrates 7 not adversely affected. Although initial levels were similar those...
In Australia, there are no current national estimates of the risks transmission human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV) or T-lymphotrophic (HTLV) by musculoskeletal tissue transplantation. We determined prevalence rates antibodies against HIV (anti-HIV), HCV (anti-HCV) and HTLV (anti-HTLV) Hepatitis surface antigen (HBsAg) for 12,415 donors from three major bone banks across Australia period 1993-2004. The (per 100,000 persons) was 64.44 anti-HIV, 407.13 HBsAg, 534.63...
In a group of six normal male volunteers, infusion DDAVP, venous occlusion and exercise were shown to increase plasma levels factor VIII plasminogen activator, activity antigen, different extents at differing rates. Any mechanisms suggested explain release these proteins by various stimuli should account for such differences. All three could also prostacyclin metabolites, although this was only significant high doses DDAVP. Other potential endothelial markers, as fibronectin thrombospondin,...
Background Immunoglobulin ( Ig ) G replacement with intravenous or subcutaneous immunoglobulins is a lifelong substitutive therapy in patients primary antibody deficiencies PADs ). Hemolysis after immunoglobulin was described receiving high dosages. The issue of hemolysis administration at doses has been considered little clinical significance. Study Design and Methods This single‐center observational study over 2‐year period on immunoglobulin‐induced cohort 162 PAD s treated administered...
We assessed the health-related quality of life (HRQoL) in CVID adults receiving different schedules immunoglobulin replacement therapy (IgRT) by intravenous (IVIG), subcutaneous (SCIG), and facilitated (fSCIG) preparations. For these patients, IgRT schedule was chosen after a period focused on identifying most suitable individual option. Three hundred twenty-seven participants were enrolled prospective, observational, 18-month study. Participants received for at least 2 years. The first 6...
Although the funding of rare diseases such as haemophilia in developing countries remains a low priority, pressures on treatment are also emerging developed economies affected by global economic downturn and other demands health care budgets. This is leading advisory bodies payers alike to explore tools Health Technology Assessment (HTAs) deriving recommendations for reimbursement policies. In particular, use cost utility analysis (CUA) costs per quality adjusted life year (QALY) different...