A5063380652- Blood donation and transfusion practices
- Blood transfusion and management
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Erythrocyte Function and Pathophysiology
- Prion Diseases and Protein Misfolding
- Organ Donation and Transplantation
- Blood disorders and treatments
- Complement system in diseases
- Neonatal Health and Biochemistry
- Cardiac, Anesthesia and Surgical Outcomes
- Hematopoietic Stem Cell Transplantation
- Iron Metabolism and Disorders
- Aortic aneurysm repair treatments
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood properties and coagulation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac and Coronary Surgery Techniques
- Sinusitis and nasal conditions
- Pluripotent Stem Cells Research
- Erythropoietin and Anemia Treatment
Basil Hetzel Institute
2024
The University of Adelaide
2024
Central Adelaide Local Health Network
2024
Irish Blood Transfusion Service
2009-2022
University College Dublin
2010-2022
Wellington Hospital
2018-2022
University of Tennessee Health Science Center
1983-2022
University of Kentucky
2020
Pain Management Center of Paducah
2020
University of Wisconsin–Madison
2020
Knowledge management (KM) has emerged in recent times as a phenomenon with wide‐ranging implications for organizational innovation and competitiveness. Supporters argue that organizations understand the value of KM, they have opportunity to establish long‐term internal strengths, which will lead external competitive advantage. Further, we find current literature advocates KM can be implemented every discipline. is approached from several different perspectives, number these are used...
Fresh frozen plasma should only be used to treat bleeding episodes or prepare patients for surgery in certain defined situations. Definite indications the use of FFP: 1. Replacement single coagulation factor deficiencies, where a specific combined concentrate is unavailable. 2. Immediate reversal warfarin effect. 3. Acute disseminated intravascular (DIC). 4. Thrombotic thrombocytopenic purpura (TTP). Conditional uses: FFP indicated presence and disturbed coagulation: Massive transfusion....
We introduced 100% screening of platelets for bacterial contamination in 2005 to reduce the risk clinical sepsis from platelet transfusion. test all outdating units again at expiry assess sensitivity initial test.We concentrates prior release use using a large volume automated culture technique on day after manufacture. All that expire unused are retested. Platelets still stock 4 storage may have repeat performed, and returned with two extra days shelf life.Of 43,230 screened, 35 (0.08%)...
Jean-Pierre Allain and colleagues argue that, while unintended, the foreign aid provided for blood transfusion services in sub-Saharan Africa has resulted serious negative outcomes, which requires reflection rethinking.
Describing the microbial community within tumour has been a key aspect in understanding pathophysiology of microenvironment. In head and neck cancer (HNC), most studies on tissue samples have only performed 16S rRNA short-read sequencing (SRS) V3-V5 region. SRS is mostly limited to genus level identification. this study, we compared full-length long-read (FL-ONT) from Oxford Nanopore Technology (ONT) V3-V4 Illumina (V3V4-Illumina) 26 HNC tissues. Further validation was also using...
SUMMARY. Recommendations for the optimal transfusion support of patients likely to receive repeated platelet transfusions 1 Determine policy prophylactic support, and select count below which will be used. 2 Consider using leucocyte depletion red cell concentrates prevent HLA alloimmunization from outset. 3 Type HLA-A B antigens at an early stage. 4 Use random donor initial (either single or multiple donor, depending on availability). 5 If refractoriness occurs, determine whether clinical...
Introduction Circulating microparticles (MP) have been described in sickle cell anaemia (SCA); however, their interaction with endothelial markers remains unclear. We investigated the relationship between MP, protein C (PC), free S (PS), nitric oxide (NO), endothelin‐1 (ET‐1) and adrenomedullin (ADM) a large cohort of paediatric patients. Method A total 111 children African ethnicity SCA: 51 steady state; 15 crises; 30 on hydroxyurea (HU) therapy; transfusion; 17 controls (HbAA) similar...
BACKGROUND Hepatitis E virus (HEV) Genotype 3 (G3) infection is a zoonosis that may be transmitted during the acute phase by transfusion. The aim of this study was to determine incidence HEV and seroprevalence among Irish blood donors. STUDY DESIGN AND METHODS Anonymized samples from 1076 donations collected in 2012 were tested for immunoglobulin (Ig)G using Wantai enzyme‐linked immunosorbent assay. A total 24,985 anonymized between December 2013 June 2014 individually RNA Procleix assay;...
EU law requires a haemoglobin of > or = 12.5 g/dl for women 13.5 men at the time donation. As capillary and venous values may differ in same subject, we examined whether level 12.0 13.0 men, is equivalent to g/dl, respectively, avoid unnecessary loss blood donations.Over continuous 42-month period, 36 258 paired samples were taken from 25 762 females 10 496 males, when was < respectively.Venous levels higher than levels, with mean difference 1.07 (SD 0.68 g/dl), range -2.2 +3.25 (P 0.001),...
Summary We have previously observed calpain activity (calcium‐dependent cysteine protease) in sera from patients with acute thrombotic thrombocytopenic purpura (TTP). The was not present following recovery and detected other disorders. postulated that this enzyme could participate the pathogenesis of TTP. Because investigators demonstrated abnormalities von Willebrand factor (vWF) TTP, we proposed might interact vWF To challenge hypothesis, measured binding untreated calpain‐treated to...
Summary We describe a prospective study comparing four different assays for PAIgG. Platelets from patients with variety of thrombocytopenic disorders were collected into ACD, washed, and the PAIgG then measured using three surface These included: (a) direct binding assay 125 I‐monoclonal anti‐IgG (MoAb); (b) I‐staphylococcal protein A (SPA); (c) two‐stage assay. also was an ‘total’ following platelet lysis. The mean ± SD number molecules IgG per on washed platelets 29 healthy,...
Objectives: To evaluate the short-term efficacy and safety of desvenlafaxine (25–50 mg/d) compared with placebo in children adolescents major depressive disorder (MDD). Methods: Outpatient (7–11 years) (12–17 who met DSM-IV-TR criteria for MDD had screening baseline Children's Depression Rating Scale–Revised (CDRS-R) total scores >40 were randomly assigned to 8-week treatment placebo, (25, 35, or 50 mg/d based on weight), fluoxetine (20 mg/d). The primary endpoint was change from CDRS-R...
BACKGROUND: Blood transfusion in rural sub‐Saharan Africa presents special challenges. Transfusions are primarily given for emergencies—life‐threatening blood loss or anemia; is usually collected from family replacement donors; and facilities to store an adequate reserve a hospital bank constrained. We report the everyday organizational practices medium‐sized district Northern Ghana. STUDY DESIGN AND METHODS: Information data on at West Gonja Hospital, Damongo, were available laboratory...
Abstract Multiple myeloma (MM) is a heterogeneous group of disorders both genotypically and phenotypically. Response to thalidomide‐based induction therapy in newly diagnosed patients varies significantly published clinical trials. Proteomic analysis was performed on 39 MM treated with regimen (22 responders; 17 non‐responders) using immunodepletion, 2‐D DIGE mass spectrometry. Zinc‐α‐2‐glycoprotein (ZAG), vitamin D‐binding protein (VDB), serum amyloid‐A (SAA) β‐2‐microglobulin (B2M) had...
Abstract In a prospective study of 50 consecutive patients undergoing operation for ruptured abdominal aortic aneurysm, coagulation screen was performed on admission to hospital. Twenty with either platelet count &lt;100 × 109/l or prothrombin time &gt;1·5 times the control value had mortality rate 65 per cent (95 confidence interval 45–85 cent); further 23 normal results 9 0–20 cent) (P &lt;0·001). Seven patients, whom three died, did not have an performed. Patient age in group...
Aims: To estimate the rate of detection neonatal alloimmune thrombocytopenia (NAITP) in Irish population, to investigate clinical presentation and outcome affected infants, determine extent, if any, which this condition is underdiagnosed at present.Methods: Cases were collected a retrospective fashion from review platelet serology laboratory records January 1992 December 2000.Clinical data obtained hospital records.Testing for maternal antiplatelet antibody was by one or more following:...