A5045593335- Microbial Natural Products and Biosynthesis
- Tuberculosis Research and Epidemiology
- Bioactive Compounds and Antitumor Agents
- Plant-Derived Bioactive Compounds
- Computational Drug Discovery Methods
- ATP Synthase and ATPases Research
- Genomics, phytochemicals, and oxidative stress
- Microbial Metabolism and Applications
- Phytochemistry and Biological Activities
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Phytochemistry and biological activity of medicinal plants
- Antibiotic Resistance in Bacteria
- Phytochemistry Medicinal Plant Applications
- Ethnobotanical and Medicinal Plants Studies
- Genomics and Phylogenetic Studies
- Polymer Synthesis and Characterization
- Synthesis and bioactivity of alkaloids
- Metabolomics and Mass Spectrometry Studies
- Chemical Synthesis and Analysis
- Allelopathy and phytotoxic interactions
- Mitochondrial Function and Pathology
- Phytochemicals and Antioxidant Activities
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
Stellenbosch University
2022-2025
South African Medical Research Council
2022-2025
Mycobacterial pathogens present a significant challenge to disease control efforts globally due their inherent resistance multiple antibiotics. The rise of drug-resistant strains Mycobacterium tuberculosis has prompted an urgent need for innovative therapeutic solutions. One promising way discover new drugs is by utilizing natural products from the vast biochemical space. Multidisciplinary methods can used harness bioactivity these products. This study aimed evaluate antimycobacterial...
Abstract Introduction Melanoma is an aggressive form of cancer characterised by its high metabolic adaptability that contributes to drug resistance. To this end, ruthenium complexes have emerged as a promising class compounds in the discovery drugs due their unique chemical properties and potential overcome some limitations conventional chemotherapy. In our previous study, we synthesised, characterised, performed cytotoxicity tests (II) complex (GA113) against malignant A375 melanoma cell...
Computational approaches complement traditional in-vitro or in-vivo assays, significantly accelerating the drug discovery process by increasing probability of identifying promising lead compounds. In this study, apoptotic compounds were assessed for antimycobacterial activity and immunomodulatory potential in infected THP-1 macrophage cells. The was evaluated using minimum inhibitory concentration (MIC) assay. determined on mycobacterial-infected non-infected binding dynamics against InhA...
Breast cancer is a leading cause of cancer-related deaths in women globally. Even though plethora treatments are available, most patients experience adverse effects which affect their quality life. The aim this study was to investigate the utility nine Fynbos plants (Erica magnisylvae E.G.H Oliv., Erica canescens J.C. Wendl., coccinea L., glabella Thunb., corifolia Eriocephalus racemosa Hippia frutescens Salvia africana-lutea L. and an unknown plant) treating breast cancer. Solvent...
The number and diversity of drugs in the tuberculosis (TB) drug development process has increased over years, yet attrition rate remains very high, signaling need for continued research discovery. In this study, crude secondary metabolites from marine fungi associated with ascidians collected Saldanha False Bays (South Africa) were investigated antimycobacterial activity. Isolation was performed by sectioning thin inner-tissues spreading them potato dextrose agar (PDA). Solid state...
Medicinal plants play a huge role in the treatment of various diseases Limpopo province (South Africa). Traditionally, concoctions used for treating tuberculosis and cancer are sometimes prepared from plant parts naturally occurring region, these include (but not limited to) Schotia brachypetala, Rauvolfia caffra, Schinus molle, Ziziphus mucronate, Senna petersiana. In this study, aim was to evaluate potential antimycobacterial activity five medicinal against Mycobacterium smegmatis mc2155,...
Abstract The death of many people in tropical countries can be attributed to microbial infection, probably, because synthetic antibiotics are failing the treatment most infections, ability microorganisms mutate and adapt harsh conditions. This study evaluated, vitro, antimicrobial activities, antioxidant potentials, total phenolic as well phytochemical contents aqueous ethanol extracts root Cryptolepis sanguinolenta (Lindl.) crude sap Pycnanthus angolensis (Welw) using selected standard...
<title>Abstract</title> Triple-negative breast cancer (TNBC) represents a significant global health crisis due to its resistance conventional therapies and lack of specific molecular targets. This study explored the potential <italic>Eriocephalus racemosus</italic> (<italic>E. racemosus</italic>) as an alternative treatment for TNBC. The cytotoxic properties high-resolution respirometry mitochondrial activities <italic>E. against MDA-MB 231 TNBC cell line were evaluated....
Abstract The death of many people in tropical countries can be attributed to microbial infection, probably, because synthetic antibiotics are failing the treatment these infections, ability microorganisms mutate and adapt harsh conditions. This study evaluated, vitro , antimicrobial activities, antioxidant potentials, total phenolic contents aqueous ethanol extracts root Cryptolepis sanguinolenta (Lindl.) crude sap Pycnanthus angolensis (Welw) using selected standard bacteria strains ( S....