Abstract A new biomaterial, a degradable thermoset polymer, was made from simple, economical, biocompatable monomers without the need for catalyst. Glycerol and citric acid, nontoxic renewable reagents, were crosslinked by melt polymerization reaction at temperatures 90 to 150°C. Consistent with condensation reaction, water determined be primary byproduct. The amount of crosslinking controlled conditions, including temperature, time, ratio between glycerol acid. Also, inversely proportional...

Mapping molecular sub-types in breast cancer (BC) tumours is a rapidly evolving area due to growing interest in, for example, targeted therapy and screening high-risk populations early diagnosis. We report new concept profiling BC based on volatile organic compounds (VOCs). For this purpose, breath samples were collected from 276 female volunteers, including healthy, benign conditions, ductal carcinoma situ (DCIS) malignant lesions. Breath analysed by gas chromatography mass spectrometry...

Well-ordered nanoparticle arrays are attractive platforms for a variety of analytical applications, but the fabrication such is generally challenging. Here, it demonstrated that scanning electrochemical cell microscopy (SECCM) can be used as powerful, instantly reconfigurable tool ordered arrays. Using SECCM, Ag were straightforwardly fabricated via electrodeposition at interface between substrate electrode and an electrolyte-filled pipet. By dynamically monitoring currents flowing in SECCM...

We examine the effect that commercial sterilization techniques have on physical, mechanical, and drug delivery properties of polyurethane polymers.

This review focuses on recent advances in non-enzymatic electrochemical biosensors for detection of hydrophobic metabolites. Electrochemical approaches have been widely applied many established and emerging technologies a large range used various Despite the progress made this field, some problems still exist, specifically, biomarkers can be challenging complex biological fluids. In review, we highlighted most representative surface modification that employed to counter poor sensitivity...

The aim of this work is to develop a reusable polypropylene glycol (PPG):β-cyclodextrin (βCD) biosensor for cortisol detection. To achieve the most stable support βCD, we developed two PPG surfaces. first surface based on gold modified with SAM 3-mercaptopropionic acid (3MPA), and second glassy carbon grafted 4-carboxyphenyl diazonium salt. We characterized both surfaces by EIS, XPS, ATR-FTIR evaluated stability reusability each surface. found GC-carboxyphenyl-PPG:βCD at least 1 month. have...

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> An integrated circuit for wireless real-time monitoring of neurochemical activity in the nervous system is described. The chip capable conducting high-resolution amperometric measurements four settings input current. architecture includes a first-order <formula formulatype="inline"><tex Notation="TeX">$\Delta$</tex></formula> Notation="TeX">$\Sigma$</tex></formula> modulator (<formula...

Controlling the sensing properties of a silicon nanowire field effect transistor is dependent on surface chemistry nanowire. A standard has passive oxide layer (native oxide), which trap states that cause inaccuracies and desensitize to nonpolar molecules. In this paper, we successfully modified with different nonoxide C3 alkyl groups, specifically, propyl (Si–CH2–CH2–CH3), propenyl (Si–CH═CH–CH3), propynyl (Si–C≡C–CH3) modifications. The near bond sensor sensitivity stability was explored...

The use of highly cross-linked molecularly imprinted polymers as a synthetic target receptor has the limitations restricted accessibility to binding sites, resulting in slow response time. Moreover, such artificial receptors often require additional transduction mechanisms translate events into measurable signals. Here, we propose development single-chain stimuli-responsive templated polymer, without using any covalent interchain cross-linkers, recognition element. synthesized polymer chain...

Garter snakes increase tongue-flick rates in the presence of airborne odorants (amyl acetate, limonene, earthworm wash vapor, fish water earthworms, goldfish) but not vapor. Main olfactory (MO) nerve lesions result loss this rate elevation odorants. Vomeronasal (VN) a diminution elevation. discriminate between 2 arms maze containing odor as compared with blank control. Following MO lesions, fail to make discrimination. VN or duct suture, are initially able discrimination may eventually cease...

Electrochemical detection of amino acids is important due to their correlation with certain diseases; however, most require a catalyst electrochemically activate. One common for electrochemical are metal oxides. Metal oxide nanoparticles were electrodeposited onto glassy carbon and platinum working electrodes. Cyclic voltammetry (CV) experiments in flow cell performed evaluate the sensors’ ability detect arginine, alanine, serine, valine at micromolar nanomolar concentrations as high 4 mM....

This mini review investigates the relationship and interactions of polymers under an applied electric field (AEF) for sensor applications. Understanding how why are reoriented manipulated AEF is essential future growth in polymer-based electrochemical sensors. Examples that can be applications provided. Current methods monitoring polymer reorientation will described, but new techniques needed to characterize response various stimuli. The unique reproducible stimuli elicited by has...

Elastin-like polymers (ELPs) are frequently used in a variety of bioengineering applications because their stimuli-responsive properties. Above transition temperature, ELPs will adopt different structures that promote intra- and intermolecular hydrophobic contacts to minimize unfavorable interactions with an aqueous environment. We electrochemically characterize the behavior surface-immobilized corresponding two proposed states: extended collapsed. In state more solvated. collapsed state,...

A reusable sensor architecture, through the combination of self-assembled monolayers and cyclodextrin supramolecular interactions, is demonstrated for class recognition hydrophobic analytes with trans-resveratrol. The reloadable based on reversible immobilization α-cyclodextrin polyethylene glycol surface. α-cyclodextrins complexes glycols causes polymer chains to change their surface configuration. reproducibility stability sur-face, in detection nanomolar concentrations trans-resveratrol,...

Abstract In this work-in-progress research paper, we discuss our approaches to undergraduate mentoring strategies towards neurodivergent student's conducting STEM research. Despite the increase in students who report disabilities, few resources are available train mentors work with population. The community is often inappropriately perceived have disadvantages STEM-based and face exacerbated challenges when pursuing faculty. We investigate different that support researchers thrive. First,...

Electrochemical impedance spectroscopy (EIS) is a technique used to characterize physiochemical processes, especially in the field of biosensors. However, EIS has been known have reproducibility issues due an inherent drift. When taking repeated measurements same exact solution using EIS, increasing trend which can be detailed by linear slope. The reported drift ranges from 0.11 5.5 Ω/min. We studied assist with future data interpretation and model fitting. discovered cleanliness treatment...

This paper reports on technology development at the sensor and circuit levels for wireless transmission of fast- scan cyclic voltammetry (FSCV) in neurochemical detection. Heavily conductive, boron-doped diamond is selectively deposited onto polished tip a tungsten microelectrode to fabricate versatile, implantable, micro-needle microprobes capable sensing brain. In addition, an integrated fabricated 0.5-mum CMOS processing electrochemical signals corresponding extracellular concentration...

We initially tested the electrochemical activity of beta-carotene and lutein at unmodified glassy carbon electrodes. found good sensitivity (1 nA/µM) high, micromolar concentrations, but serum levels are nanomolar concentrations. To enhance activity, we modified sensor surface with β-cyclodextrin, which has a hydrophobic core. Our goal was that will be attracted to β-cyclodextrin core, increasing interaction sensitivity. Instead saw decrease in activity. Further investigation methylene blue...

NG-hydroxy-L-arginine (NOHA) is a stable intermediate product in the consumption of L-arginine urea cycle by nitric oxide synthase (NOS) to produce (NO) and L-citrulline. Research has shown that disrupted various diseases. As one few electrochemically active species cycle, NOHA shows promise as marker for detection Electrochemical an established, cost-effective method able successfully detect low levels analyte concentrations. NOHA, best our knowledge, not been detected previously. Using...