A5025211740- Plant tissue culture and regeneration
- Plant Reproductive Biology
- Plant Virus Research Studies
- Horticultural and Viticultural Research
- HIV/AIDS drug development and treatment
- Plant Genetic and Mutation Studies
- Plant Disease Management Techniques
- Seed Germination and Physiology
- Plant and animal studies
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Peanut Plant Research Studies
- Sesame and Sesamin Research
- Cytomegalovirus and herpesvirus research
- Chemical Reactions and Mechanisms
- Plant Pathogens and Fungal Diseases
- Herpesvirus Infections and Treatments
- Inorganic and Organometallic Chemistry
- Chemical Synthesis and Analysis
- Plant Pathogens and Resistance
- Transgenic Plants and Applications
- Agricultural Economics and Practices
- Essential Oils and Antimicrobial Activity
- GABA and Rice Research
- Synthesis and Characterization of Heterocyclic Compounds
The University of Adelaide
2022-2024
Plant & Food Research
2011-2023
Australian Centre for Plant Functional Genomics
2022
Agriculture and Food
2020-2021
General Sir John Kotelawala Defence University
2015-2016
Cardiff University
2004-2013
University of Ruhuna
1987-2013
Massey University
2005
Rega Institute for Medical Research
2004
University of Wales
2001
Despite world food production keeping pace with population growth because of the Green Revolution, United Nations (UN) State Food Security and Nutrition in World 2022 Report indicates that number people affected by hunger has increased to 828 million 29.3% global insecure, 22% children under five years age stunted. Many more have low-quality, unhealthy diets micronutrient deficiencies leading obesity, diabetes, other diet-related non-communicable diseases. Additionally, current agro-food...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives AZTChristopher McGuigan, Ranjith N. Pathirana, Jan Balzarini, and Erik De ClercqCite this: J. Med. Chem. 1993, 36, 8, 1048–1052Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://doi.org/10.1021/jm00060a013RIGHTS & PERMISSIONSArticle Views1050Altmetric-Citations168LEARN ABOUT THESE METRICSArticle...
Abstract A mutation is a sudden heritable change in the DNA living cell, not caused by genetic segregation or recombination. Mutation breeding purposeful application of mutations plant breeding. Unlike hybridization and selection, has advantage improving defect an otherwise elite cultivar, without losing its agronomic quality characteristics. only straightforward alternative for seedless crops. Since first release mutant cultivars that resulted from basic research Europe, found niche because...
Certain viruses dramatically affect yield and quality of potatoes have proved difficult to eradicate with current approaches. Here, we describe a reliable efficient virus eradication method that is high throughput more efficacious at producing virus-free potato plants than reported methods. Thermotherapy, chemotherapy, cryotherapy treatments were tested alone in combination for ability single mixed Potato S (PVS), A (PVA), M (PVM) infections from three cultivars. Chemotherapy undertaken on...
Soil salinity is one of the main barriers to increasing global food production as it reduces crop growth and productivity. While irrigated lands in arid climates (about 20% total affected) are more prone salinization, many other natural anthropogenic factors contribute an increase arable that currently affects over 100 countries than billion ha. Management agro-ecosystems at every level, including soil, water, plant itself, important mitigating effects salinity. Plant hormones control...
The phosphoramidate triester prodrugs of anti-human HIV 2', 3'-dideoxynucleoside analogs (ddN) represent a convenient approach to bypass the first phosphorylation ddN 5'-monophosphate (ddNMP), resulting in an improved formation 5'-triphosphate and, hence, higher antiviral efficacy. Although derivatization markedly increases anti-HIV activity 2',3'-didehydro-2', 3'-dideoxythymidine (d4T) both wild-type and thymidine kinase-deficient CEM cells, concept is far less successful for...
To progress the anti-varicella-zoster-virus (VZV) aryl bicyclic nucleoside analogues (BCNAs) to point of Phase 1 clinical trial for herpes zoster.A new chromatography-free synthetic access lead anti-VZV BCNAs is reported. The activity Cf1743 was evaluated in monolayer cell cultures and organotypic epithelial raft primary human keratinocytes. Oral dosing rodents preliminary pharmacokinetics assessment made, followed by an exploration alternative formulations preparation pro-drugs. We also...
ABSTRACT Through in vitro tissue culture techniques it is possible to propagate high quality nursery plants faster. Cryotherapy a promising tool, based on techniques, for achieving short time, frequency of regenerating free viruses. The objective this review present and analyze the results research conducted cryotherapy methods cryopreservation protocols recovery cultivars micro-organisms with potential agronomic interest. main employed are encapsulation-dehydration, vitrification,...
Selenium is an essential micronutrient that critical for the maintenance of human health. It has a significant impact on immune function and effective in prevention several metabolic-related illnesses. Furthermore, Se deficiency affects millions worldwide, particularly regions such as China, Eastern Europe, Africa. This review examines current knowledge biofortification, specifically focusing application to plants soils, mechanism uptake utilization, genetic variation accumulation,...
Ruhuna Journal of Science (RJS) is a multidisciplinary published by the Faculty Science, University Ruhuna. It welcomes articles resulting from original research work covering many areas in Pure and Applied Sciences, Technology, scientific with interdisciplinary focus.Ruhuna indexed Web (Master List/ Zoological Records), included on DOAJ World Catalogue Scientific Journals (WCOSJ).To submit your manuscript please go to http://rjs.ruh.ac.lk/index.php/rjs/indexCover Page ImageYala (යාල)...
A robust method for removing all microorganisms from infected tissue is important cultivar imports, germplasm maintenance and to produce healthy grafted material the grapevine industry. In droplet vitrification of cryopreservation, plant pre-treated with a solution placed on aluminium foil in directly immersed liquid nitrogen. Only highly cytoplasmic, non-vacuolar meristematic cells survive freezing. Therefore, cryopreservation can be considered precise meristem culture developing into new...
We describe a droplet‐vitrification cryotherapy method for the eradication of grapevine leafroll‐associated virus‐3 (GLRaV‐3) from diseased in vitro shoots Vitis plants. The procedure involved pre‐culture 1.0‐mm shoot tips containing five to six leaf primordia (LPs) 3 days with medium 0.3 M sucrose, 0.16 mM glutathione and 0.14 ascorbic acid, treatment pre‐cultured 20 min at room temperature loading solution composed 2 glycerol 0.4 sucrose exposure plant vitrification (PVS2), prior freezing...
Following our discovery of the potent anti-varicella zoster virus action lipophilic alkyl furano pyrimidine 2'-deoxynucleosides, we now report that 2',3'-dideoxy sugar analogues are devoid anti-VZV activity but and selective inhibitors human cytomegalovirus (HCMV). The present compounds active in vitro at ca. 1 μM with cytotoxicity only above 200 μM. Importantly, have discovered new agents do not act as nucleoside analogues, despite their nucleosidic structure, time addition studies revealed...
Methylselenocysteine (MeSeCys) is an amino acid derivative that possesses potent anticancer activity in animals. Plants can tolerate growth on soils with high Se content, known as hyperaccumulators, do so by converting inorganic to MeSeCys the enzyme selenocysteine methyltransferase (SMT). A cDNA encoding SMT from a hyperaccumulator was overexpressed tomato (Solanum lycopersicum). Transgenic plants were provided selenite or selenate roots during fruit development, and liquid...