A5011611970- Liver Disease Diagnosis and Treatment
- Diverticular Disease and Complications
- Colorectal Cancer Screening and Detection
- NF-κB Signaling Pathways
- Bone Metabolism and Diseases
- Bone health and treatments
- Esophageal and GI Pathology
- Dental Implant Techniques and Outcomes
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Dental materials and restorations
- Genetic factors in colorectal cancer
- Zebrafish Biomedical Research Applications
- Cancer Cells and Metastasis
- Bariatric Surgery and Outcomes
- Cardiovascular Disease and Adiposity
- Neonatal Respiratory Health Research
- Neuroblastoma Research and Treatments
- Pluripotent Stem Cells Research
- RNA Interference and Gene Delivery
- Tattoo and Body Piercing Complications
- T-cell and B-cell Immunology
- Phagocytosis and Immune Regulation
- Helicobacter pylori-related gastroenterology studies
Boston Medical Center
2020-2024
Boston University
2020-2024
University Medical Center
2023
Albany Medical Center Hospital
2015
Amgen (United States)
1998-2000
Institute of Cell Biology
2000
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary precursor cell cDNA library is identical to the tumor necrosis factor (TNFR) family member RANK. The RANK mRNA was highly expressed by isolated bone marrow-derived progenitors mature osteoclasts in vivo. Recombinant OPGL binds specifically transfected lines purified progenitors. Transgenic mice expressing soluble RANK-Fc fusion protein...
Osteoclast precursors (OCPs) circulate in the mononuclear fraction of peripheral blood (PB), but their abundance and surface characteristics are unknown. Previous studies suggest that receptor activator for NF-kappaB (RANK) on cytokine-treated OCPs mouse bone marrow interacts with osteoprotegerin ligand (OPGL/TRANCE/RANKL/ODF) to initiate osteoclast differentiation. Hence, we used a fluorescent form human OPGL (Hu-OPGL-F) identify possible RANK-expressing untreated cells (PBMCs) using...
Abstract Background & Aims Non‐alcoholic fatty liver disease confers increased risk for cardiovascular disease, including heart failure (HF), reasons that remain unclear. Possible pathways could involve an association of fat with cardiac structural or functional abnormalities even after accounting body size. Methods We analysed N = 2356 Framingham Heart Study participants (age 52 ± 12 years, 52% women) who underwent echocardiography and standardized computed tomography measures fat....
Osteoclast precursors (OCPs) circulate in the mononuclear fraction of peripheral blood (PB), but their abundance and surface characteristics are unknown. Previous studies suggest that receptor activator for NF‐κB (RANK) on cytokine‐treated OCPs mouse bone marrow interacts with osteoprotegerin ligand (OPGL/TRANCE/RANKL/ODF) to initiate osteoclast differentiation. Hence, we used a fluorescent form human OPGL (Hu‐OPGL‐F) identify possible RANK‐expressing untreated cells (PBMCs) using...
Leptin and the leptin receptor are key players in regulation of body weight. In an attempt to dissect molecular mechanism Zucker <i>fatty</i> rat mutation (Gln<sup>269</sup> → Pro) we analyzed effects this on signaling expression three different systems: 1) 32D cells expressing leptin/erythropoietin chimeras, 2) COS-7 a short form, 3) 293 soluble forms. To determine if Gln<sup>269</sup> Pro is critical for observed phenotype, made similar Gln at vicinal residue two amino acids upstream see...
Ethylene inhibits polar cell expansion of etiolated pea (Pisum sativum) internode tissue and results in a radial expansion, swelling. A special gas-tight growth chamber was developed to monitor continuously the induction inhibition excised segments presence ethylene. Following complex period which lasts about 3 hours, low, but steady-state rate is achieved. removal experiments indicate that gas induces an irreversible change mode. If transferred ethylene-free after had been achieved, this...
Non-Hispanic Black (NHB) patients with early-onset colorectal cancer (EOCRC) are more likely to present advanced-stage disease than their White (NHW) counterparts. To further elucidate whether differences in tumor biology or disparities access care may be responsible, we examined the association between race/ethnicity and initial stage of disease, time diagnosis, characteristics among NHW NHB EOCRC cared for a safety-net health setting.
Introduction: Intragastric balloon therapy is a minimally invasive, non-surgical restrictive weight loss procedure that promotes early satiety and delayed gastric emptying, resulting in reduced caloric intake. Common adverse effects include nausea, vomiting, abdominal pain, reflux. More serious are rare, migration, ulceration perforation, acute pancreatitis. Case Description/Methods: We report 2 cases of 44- 51-year-old women who both presented with intractable nausea severe hypokalemia...
Introduction: Current guidelines recommend that patients with iron deficiency anemia (IDA) be considered for bidirectional endoscopy. Heterogeneity in performing terminal ileum (TI) intubation exists among endoscopists when evaluating IDA, and the incremental yield of this maneuver is unknown. We investigated diagnostic TI during workup IDA within a diverse, safety-net hospital population. Methods: performed single-center, retrospective cohort study who underwent ileocolonoscopy evaluation...