A5101510255- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Sleep and Wakefulness Research
- Synthesis of Organic Compounds
- Spinal Cord Injury Research
- Genetic Neurodegenerative Diseases
- Carbohydrate Chemistry and Synthesis
- Medical History and Innovations
- Molecular Biology Techniques and Applications
- Nerve injury and regeneration
- Natural Compound Pharmacology Studies
- Metabolism and Genetic Disorders
- Electrospun Nanofibers in Biomedical Applications
- Cervical and Thoracic Myelopathy
- GDF15 and Related Biomarkers
- Cancer-related gene regulation
- Glycogen Storage Diseases and Myoclonus
- Galectins and Cancer Biology
- History of Medicine Studies
- Botulinum Toxin and Related Neurological Disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Nosocomial Infections in ICU
- Mesenchymal stem cell research
- History of Medical Practice
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Peking Union Medical College Hospital
2019-2024
Fuwai Yunnan Cardiovascular Hospital
2021-2024
Huazhong University of Science and Technology
2021
Hebei General Hospital
2020
Albert Einstein College of Medicine
2005
University of California, Irvine
2005
National Institutes of Health
1998
Parkinson's disease (PD) is the second-most common neurodegenerative after Alzheimer's disease. The most important pathological feature of PD irreversible damage dopamine neurons, which related to autophagy and neuroinflammation in substantia nigra. Previous studies found that activation NAcht Leucine-rich repeat Protein 3 (NLRP3) inflammasome/pyroptosis cell division protein kinase 5 (CDK5)-mediated played an role PD. Bioinformatics analyses further predicted microRNA (miR)-188-3p...
Background Sleep fragmentation is a persistent problem throughout the course of Parkinson’s disease (PD). However, related neurophysiological patterns and underlying mechanisms remained unclear. Method We recorded subthalamic nucleus (STN) local field potentials (LFPs) using deep brain stimulation (DBS) with real-time wireless recording capacity from 13 patients PD undergoing one-night polysomnography recording, 1 month after DBS surgery before initial programming when were off-medication....
Abstract Introduction Mesenchymal stromal cells (MSCs) play an important role in the prevention of cell and tissue fibrosis. Senescence may decrease function MSCs during recovery from organ damage. Extracellular vesicles (EVs) released contribute to repair kidney injury. We explored influence senescence on EVs derived (MSC-EVs) detected protective effects MSC-EVs expressing low levels miR-294/miR-133 old rats against chronic disease (CKD). Methods The 3-month-old 18-month-old male Fisher 344...
Background Tetanus is a rare surgical infectious disease with high reported relevant mortality. It still remains serious problem in public health, particularly low-income and middle-income countries. The purpose of this study was to investigate the management prognosis adult generalized tetanus our hospital. Methods A total 20 patients were recruited retrospective observational study. Patients retrieved from hospital data base via discharge diagnosis. divided into two groups (Severe or...
Abstract Background Abnormal rapid eye movement (REM) sleep, including REM sleep behavior disorder (RBD) and reduced is common in Parkinson's disease (PD), highlighting the importance of further study on sleep. However, biomarkers disturbances remain unknown, leading to lack REM‐specific neuromodulation interventions. Objective This aims investigate neurophysiological disturbance parkinsonian patients. Methods Ten PD patients implanted with bilateral subthalamic nucleus‐deep brain...
Deep brain stimulation (DBS) is an established safe neurosurgical symptomatic therapy for Parkinson's disease (PD) in whom medical treatment fails to provide adequate symptom control. Skin-related complications, particularly skin erosion, may lead exposure of the DBS device, compromising effectiveness device. We presented a patient who suffered from erosion over bilateral burr hole site. A Multidisciplinary Team (MDT) approach was used staged surgical scalp reconstruction. Without removal...
Objective: To investigate the clinical characteristics and surgical treatment of cervical spondylotic amyotrophy. Methods: Thirteen patients(13 man) with proximal (10) distal(3) amyotrophy between November 2014 September 2016 were included in this study. The average age patients was 55 (range, 47-66) years. sex, age, course, type amyotrophy, lesion segment postdecompression improvement muscle power reviewed. Results: Of 13 patients, 9 performed on disectomy, 2 posterior operation, remainding...
Abstract Background: Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) can be used to treat motor symptoms and dyskinesia in advanced stages of Parkinson’s disease (PD). High frequency (HFS) STN lead consistent, long-term improvement PD symptoms. However, effects HFS on axial PD, specifically freezing gait (FOG), limited or cause further impairment. While this alleviated via relatively low (LFS) select patients, LFS does not control all PD. Recently, National Engineering...
Abstract Background Sleep fragmentation is a persistent problem throughout the course of Parkinson’s disease (PD). However, related neurophysiological patterns and underlying mechanisms remained unclear. Method We recorded subthalamic nucleus (STN) local field potentials (LFPs) using DBS with real-time wireless recording capacity from thirteen PD patients undergoing one-night polysomnography recording, one month after surgery before initial programming when were Off-Medication. The STN LFP...
Abstract Background: Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) can be used to treat motor symptoms and dyskinesia in advanced stages of Parkinson’s disease (PD). High frequency (HFS) STN lead consistent, long-term improvement PD symptoms. However, effects HFS on axial PD, specifically freezing gait (FOG), limited or cause further impairment. While this alleviated via relatively low (LFS) select patients, LFS does not control all PD. Recently, National Engineering...
Abstract Background: Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) can be used to treat motor symptoms and dyskinesia in advanced stages of Parkinson’s disease (PD). High frequency (HFS) STN lead consistent, long-term improvement PD symptoms. However, effects HFS on axial PD, specifically freezing gait (FOG), limited or cause further impairment. While this alleviated via relatively low (LFS) select patients, LFS does not control all PD. Recently, National Engineering...
Table S1 Overview of characteristics for 9 cases diagnosed with dystonia-deafness syndrome related to a mutation in the β-actin (ACTB) gene. Please note: The publisher is not responsible content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed corresponding author article.
Due to their fascinating chemical structures and extensive pharmacological activities, polycyclic polyprenylated acylphloroglucinols(PPAPs) have become one of the current research hotspots natural products. In particular, some PPAPs not only novel non-traditional skeleton types, but also contain more unknown possible which are great significance for development lead compounds. The structure, source, biosynthetic pathway activities with non-traditio-nal types isolated identified in recent...
This study aims to investigate the methods for rat spinal cord ischemia injury models with a high long-term survival rate.The rats were divided into three groups: treatment group, control and sham operation group. The group had blocked thoracic aorta (landing zone 3 by Ishimaru - T11) + aortic bypass circulation 20 min. In at landing was only thoracotomy without occlusion performed. mean arterial blood pressure (MABP) of caudal artery before after monitored intraoperatively. Spinal function...