A5031961506- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA modifications and cancer
Wuhan Sixth Hospital
2021
To study the relationship between circular RNA vesicle-associated membrane protein-associated protein A (circVAPA) and pathogenesis of oral squamous cell carcinoma.The expression circVAPA was detected by RT-qPCR. In vitro loss-of-function experiments were performed in Cal-27 cells. The malignant phenotype cells evaluated counting kit-8, clone formation transwell assays. Luciferase reporter assays used to assess circVAPA/miR-132/homeobox (HOXA) regulatory axis.circVAPA significantly increased...
Oral squamous cell carcinoma (OSCC) ranks sixth among malignancies in the world, and there are 200,000 new cases annually, rendering OSCC a significant global public health issue that has caused great burdens on patients, society, economy. Despite progress diagnosis treatment methods, patient survival not been greatly enhanced. Hence, is an urgent need to identify novel targets can serve as early diagnostic therapeutic biomarkers for OSCC. Long non-coding RNAs (lncRNAs) participate several...