Chiuan Herng Leow

ORCID: 0000-0003-0849-428X
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About
Contact & Profiles
Research Areas
  • Monoclonal and Polyclonal Antibodies Research
  • vaccines and immunoinformatics approaches
  • SARS-CoV-2 and COVID-19 Research
  • Bacteriophages and microbial interactions
  • Glycosylation and Glycoproteins Research
  • Fungal Biology and Applications
  • Polysaccharides and Plant Cell Walls
  • Immunotherapy and Immune Responses
  • Mosquito-borne diseases and control
  • Escherichia coli research studies
  • Malaria Research and Control
  • Viral gastroenteritis research and epidemiology
  • Advanced Biosensing Techniques and Applications
  • Insect symbiosis and bacterial influences
  • Protein purification and stability
  • HIV Research and Treatment
  • Seaweed-derived Bioactive Compounds
  • Advanced biosensing and bioanalysis techniques
  • Immune Cell Function and Interaction
  • Vaccine Coverage and Hesitancy
  • Bacterial Infections and Vaccines
  • RNA and protein synthesis mechanisms
  • Pneumonia and Respiratory Infections
  • Phytochemistry and Bioactivity Studies
  • Salmonella and Campylobacter epidemiology

Universiti Sains Malaysia
2017-2024

Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, design development depended exclusively on immunological experiments which are relatively expensive time-consuming. However, recent advances field of bioinformatics have provided feasible tools can be used to lessen time cost required for development. This approach allows selection immunogenic regions from pathogen genomes. The ideal could developed as potential...

10.1080/20477724.2018.1446773 article EN Pathogens and Global Health 2018-03-12

Malaria rapid diagnostic tests (RDTs) represent an important antibody based immunoassay platform. Unfortunately, conventional monoclonal antibodies are subject to degradation shortening shelf lives of RDTs. The variable region the receptor (VNAR) from shark has a potential as alternative in RDTs due high thermal stability. In this study, new binders derived VNAR domains library were investigated. Following immunization wobbegong (Orectolobus ornatus) with three recombinant malaria biomarker...

10.1186/s12936-018-2531-y article EN cc-by Malaria Journal 2018-10-24

In the developing world, bacillary dysentery is one of most common communicable diarrheal infections. There are approximately 169 million cases shigellosis reported worldwide. The disease transmitted by a group Gram-negative intracellular enterobacteria known as Shigella flexneri, S. sonnei, dysenteriae, and boydii. Conventional treatment regimens for have been less effective due to development resistant strains against antibiotics. Therefore, an vaccine long term control transmission...

10.7774/cevr.2020.9.1.15 article EN cc-by-nc Clinical and Experimental Vaccine Research 2020-01-01
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