A5027580176- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Parasites and Host Interactions
- Immunotherapy and Immune Responses
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- S100 Proteins and Annexins
- Viral Infections and Vectors
- Malaria Research and Control
- Viral gastroenteritis research and epidemiology
- Computational Drug Discovery Methods
- Protein purification and stability
- Glycosylation and Glycoproteins Research
- Fungal Biology and Applications
- Mosquito-borne diseases and control
- Pharmacological Effects and Assays
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- T-cell and B-cell Immunology
- HIV/AIDS drug development and treatment
- Polysaccharides and Plant Cell Walls
- Cancer Immunotherapy and Biomarkers
- Transgenic Plants and Applications
Universiti Sains Malaysia
2013-2024
Hospital Universiti Sains Malaysia
2023
QIMR Berghofer Medical Research Institute
2010-2016
The University of Queensland
2010-2014
John Radcliffe Hospital
1997
Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, design development depended exclusively on immunological experiments which are relatively expensive time-consuming. However, recent advances field of bioinformatics have provided feasible tools can be used to lessen time cost required for development. This approach allows selection immunogenic regions from pathogen genomes. The ideal could developed as potential...
Pandemics in the last two centuries have been initiated by causal pathogens that include Severe Acute Coronavirus 2 (SARS-CoV-2) and Influenza (e.g., H1N1 pandemic of 2009). The latter is considered to prior pandemics 1918 1977, known as “Spanish Flu” “Russian Flu”, respectively. Here, we discuss other emerging infections could be potential public health threats. These Henipaviruses, which are members family Paramyxoviridae infect bats mammals. also Parainfluenza Mumps viruses (Rubulavirus)...
Increased expression of voltage-gated sodium channels (VGSCs) have been implicated with strong metastatic potential human breast cancer in vitro and vivo where the main culprits are cardiac isoform Nav1.5 its 'neonatal' splice variant, nNav1.5. Several factors associated nNav1.5 gain mainly hormones, growth factors.This study aimed to investigate role epigenetics via transcription repressor, repressor element silencing factor (REST) histone deacetylases (HDACs) enhancing by assessing effect...
In the developing world, bacillary dysentery is one of most common communicable diarrheal infections. There are approximately 169 million cases shigellosis reported worldwide. The disease transmitted by a group Gram-negative intracellular enterobacteria known as Shigella flexneri, S. sonnei, dysenteriae, and boydii. Conventional treatment regimens for have been less effective due to development resistant strains against antibiotics. Therefore, an vaccine long term control transmission...
In this study, we conduct an in-depth analysis of annexin proteins from a diverse range invertebrate taxa, including the major groups that contain parasites and vector organisms are harmful to humans domestic animals. Using structure-based amino acid sequence alignments phylogenetic analyses, present classification for protein group assign names sequences with ambiguous annotations in public databases. Our analyses reveal six distinct clades mapping genes encoding annexins genome human blood...
Malaria rapid diagnostic tests (RDTs) represent an important antibody based immunoassay platform. Unfortunately, conventional monoclonal antibodies are subject to degradation shortening shelf lives of RDTs. The variable region the receptor (VNAR) from shark has a potential as alternative in RDTs due high thermal stability. In this study, new binders derived VNAR domains library were investigated. Following immunization wobbegong (Orectolobus ornatus) with three recombinant malaria biomarker...
Early and accurate diagnosis of Plasmodium falciparum infection is important for providing appropriate treatment to patients with malaria. However, technical limitations currently available diagnostic tests limit their use in control programs. One possible explanation the vulnerability current antibodies used RDTs propensity degrade at high ambient temperatures. Isolation new better thermal stability represents an appealing approach improve performance RDTs. In this study, phage display...
Schistosomiasis is a major parasitic disease of humans, second only to malaria in its global impact. The caused by digenean trematodes that infest the vasculature their human hosts. These flukes are limited externally body wall composed syncytial epithelium, apical surface membrane which parasitism‐adapted dual complex. Annexins thought be integral importance for stability this system. Here, we present first structural and immunobiochemical characterization an annexin from Schistosoma...