Michael A. Packer

ORCID: 0000-0003-0854-9711
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About
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Research Areas
  • Algal biology and biofuel production
  • Aquatic Ecosystems and Phytoplankton Dynamics
  • Marine and coastal ecosystems
  • Nitric Oxide and Endothelin Effects
  • Microbial Fuel Cells and Bioremediation
  • Mitochondrial Function and Pathology
  • Electrochemical sensors and biosensors
  • Seaweed-derived Bioactive Compounds
  • Biocrusts and Microbial Ecology
  • Electrochemical Analysis and Applications
  • Protein Hydrolysis and Bioactive Peptides
  • Marine Bivalve and Aquaculture Studies
  • Microbial Community Ecology and Physiology
  • Aquaculture Nutrition and Growth
  • Polar Research and Ecology
  • Metabolism and Genetic Disorders
  • Echinoderm biology and ecology
  • Parkinson's Disease Mechanisms and Treatments
  • Sulfur Compounds in Biology
  • ATP Synthase and ATPases Research
  • Marine Toxins and Detection Methods
  • Marine and coastal plant biology
  • Electron Spin Resonance Studies
  • Photosynthetic Processes and Mechanisms
  • Molecular Sensors and Ion Detection

Cawthron Institute
2014-2023

University of Otago
1994-2014

University of Waikato
2014

MacDiarmid Institute for Advanced Materials and Nanotechnology
2009

Cold Spring Harbor Laboratory
2003-2008

National Institutes of Health
2003

Cornell University
2003

Oregon State University
2001

University College Cork
2000

The agricultural production of ruminants is responsible for 24% global methane emissions, contributing 39% emissions this greenhouse gas from the sector. Strategies to mitigate ruminant methanogenesis include use methanogen inhibitors. For example, seaweeds Asparagopsis taxiformis and armata included at low levels in feed cattle sheep inhibit by up 98%, with evidence improvements utilisation efficiency. This has resulted an increasing interest demand these globally. In response, research...

10.1016/j.algal.2022.102673 article EN cc-by-nc-nd Algal Research 2022-03-19

Neural progenitor cells are widespread throughout the adult central nervous system but only give rise to neurons in specific loci. Negative regulators of neurogenesis have therefore been postulated, none yet identified as subserving a significant role brain. Here we report that nitric oxide (NO) acts an important negative regulator cell proliferation mammalian We used two independent approaches examine function NO neurogenesis. In pharmacological approach, suppressed production rat brain by...

10.1073/pnas.1633579100 article EN Proceedings of the National Academy of Sciences 2003-07-28

MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 198:131-137 (2000) - doi:10.3354/meps198131 Mussels Mytilus edulis: significant consumers and destroyers of mesozooplankton John Davenport*, Rowan J. W. Smith, Margaret Packer University Biological Station Millport, Millport KA28 0EG, Isle Cumbrae, Scotland, UK *Present address: Department Zoology & Animal...

10.3354/meps198131 article EN Marine Ecology Progress Series 2000-01-01

Mutations and deletions in mitochondrial DNA (mtDNA) lead to a number of human diseases characterized by neuromuscular degeneration. Accumulation truncated mtDNA molecules (Δ‐mtDNA) lacking specific 4977‐bp fragment, the common deletion, leads three related : Pearson's syndrome; Kearns‐Sayre chronic progressive external ophthalmoplegia (CPEO). In addition, proportion Δ‐mtDNA present increases with age range tissues. Consequently, there is considerable interest effects accumulation on cell...

10.1046/j.1432-1327.1998.2570192.x article EN European Journal of Biochemistry 1998-10-01

Superoxide reacts with nitric oxide to form peroxynitrite, a potent oxidising agent which may contribute tissue damage in pathological situations such as inflammation and ischaemia/reperfusion. One mechanism by oxidative stress damages tissues is the induction of specific Cyclosporin A‐sensitive mitochondrial calcium efflux pathway. Here we show that peroxynitrite induces from mammalian mitochondria this blocked A. These data suggest disruption when superoxide are present together vivo.

10.1016/0014-5793(94)00461-7 article EN FEBS Letters 1994-05-30

Nitric oxide reacts rapidly with superoxide to form the potent oxidant peroxynitrite. Mitochondria in vivo produce and pathological situations amount of produced increases; therefore, presence nitric oxide, mitochondria will be a major site peroxynitrite formation. Oxidative stress induces cyclosporin‐A‐sensitive mitochondrial calcium efflux depolarisation which may contribute tissue damage situations. To determine whether could induce we exposed both simultaneously, thus subjecting...

10.1111/j.1432-1033.1995.231_c.x article EN European Journal of Biochemistry 1995-11-01

Potential electrons transfer from cyanobacteria to the electrode <italic>via</italic> osmium redox polymers.

10.1039/c4cp04307c article EN Physical Chemistry Chemical Physics 2014-01-01

Studies on biological photovoltaics based intact organisms are challenging and in most cases include diffusing mediators to facilitate electrochemical communication with electrodes. However, using such is impractical. Instead, surface confined Os‐polymers have been successfully used studies including oxidoreductases bacterial cells but not algae. Photoelectrogenic activity of a green alga, Paulschulzia pseudovolvox , immobilized graphite or Os‐polymer modified demonstrated. Direct electron...

10.1002/aenm.201501100 article EN Advanced Energy Materials 2015-08-11

Bioactive peptides range in size from 2-30 amino acids and may be derived any protein-containing biomass using hydrolysis, fermentation or high-pressure processing. Pro-peptides cryptides result shorter peptide sequences following digestion have enhanced bioactivity. Previously, we identified a protein hydrolysate generated

10.3390/md21020090 article EN cc-by Marine Drugs 2023-01-27

Abstract The mitochondrial respiratory chain continually produces superoxide leading to high levels of oxidative stress. This damage has been attributed the formation hydroxyl radicals and hydrogen peroxide from superoxide. Alternatively, may react with nitric oxide forming potent oxidant peroxynitrite, thus damaging protein, lipid DNA. To test this hypothesis we induced in presence oxide. Here demonstrate that reacts form suggesting mitochondria be a significant intracellular source peroxynitrite.

10.1080/15216549600201103 article EN IUBMB Life 1996-10-01

Abstract Biological photovoltaics (BPVs) are emerging as a potential sustainable energy‐generating technology to convert solar energy into electrical energy. Although great variety of photosynthetic biomaterials were studied in BPVs, cyanobacteria considered superior candidates because their simpler physiology. To facilitate extracellular electron transfer (EET) from electrodes is the greatest challenge improving performance BPVs. However, systematic study comparing photo‐excited EET such...

10.1002/celc.201600541 article EN ChemElectroChem 2017-01-11

Seaweeds have a long history of use as both food and medicine, especially in Asian cultures. Moreover, there is growing interest the seaweed ingredients bioactive compounds pharmaceutical nutraceutical products. One ailment that may impact hypertension caused by enzyme Angiotensin Converting Enzyme 1 (ACE-1; EC 3.4.15.1), found within Renin-Angiotensin Aldosterone System (RAAS), which causes vasoconstriction blood vessels, including veins arteries. The aim this paper to generate peptide...

10.3390/foods11121792 article EN cc-by Foods 2022-06-17

Over the last decades, several studies have reported emissions of nitrous oxide (N2 O) from microalgal cultures and aquatic ecosystems characterized by a high level algal activity (e.g. eutrophic lakes). As N2 O is potent greenhouse gas an ozone-depleting pollutant, these findings suggest that large-scale cultivation microalgae (and possibly, natural ecosystems) could significant environmental impact. Using model unicellular microalga Chlamydomonas reinhardtii, this study was conducted to...

10.1111/tpj.13544 article EN The Plant Journal 2017-03-24

10.1016/s0946-672x(96)80038-1 article EN Journal of Trace Elements in Medicine and Biology 1996-01-01
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