A5006891244- Malaria Research and Control
- Evolution and Genetic Dynamics
- Parasite Biology and Host Interactions
- Aquatic Invertebrate Ecology and Behavior
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Insect symbiosis and bacterial influences
- CRISPR and Genetic Engineering
- Marine Toxins and Detection Methods
- Invertebrate Taxonomy and Ecology
- Complement system in diseases
- Helminth infection and control
- Parasites and Host Interactions
- Nematode management and characterization studies
- Genetic diversity and population structure
- Marine and coastal ecosystems
- Protist diversity and phylogeny
- Aquaculture disease management and microbiota
- Freshwater macroinvertebrate diversity and ecology
- Religion and Sociopolitical Dynamics in Nigeria
- Microbial Community Ecology and Physiology
- HIV Research and Treatment
University of Maryland, Baltimore
2022
Texas Biomedical Research Institute
2018-2021
Sorbonne Université
2013-2016
Station Biologique de Roscoff
2013-2016
Centre National de la Recherche Scientifique
2013-2016
Agropolis International
2016
Institut de Recherche pour le Développement
2016
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2016
Abstract Organisms with sexual and asexual reproductive systems benefit from both types of reproduction. Sexual recombination generates new combinations alleles, whereas clonality favours the spread fittest genotype through entire population. Therefore, rate vs. clonal reproduction has a major influence on demography genetic structure natural populations. We addressed effect system populations dinoflagellate Alexandrium minutum . More specifically, we monitored spatiotemporal diversity...
Abstract Population genetic studies are efficient for inferring the invasion history based on a comparison of native and invasive populations, especially when conducted at species scale. An expected outcome in populations is variability loss, this true self‐fertilizing species. We here focus Pseudosuccinea columella , an hermaphroditic freshwater snail that has greatly expanded its geographic distribution acts as intermediate host Fasciola hepatica causative agent human veterinary...
Malaria symptoms are caused by the development of parasites within blood an infected host. Bulk RNA sequencing (RNA-seq) can reveal interactions between and host immune system during infection, but because multiple developmental stages with distinct transcriptional profiles concurrently present in blood, it is necessary to correct such analyses for differences cell composition among samples. Gene expression deconvolution a statistical approach that has been developed inferring complex...
Parasites play a role in the control of transient algal blooms, but it is not known whether parasite-mediated selection results coevolution host and parasites over this short time span. We investigated presence between toxic dinoflagellate Alexandrium minutum two naturally occurring endoparasites during blooms lasting month river estuaries, using cross-inoculation experiments across space. Higher parasite abundance was associated with large daily reduction relative A. abundances,...
Malaria patients can carry one or more clonal lineage of the parasite, Plasmodium falciparum , but composition these infections cannot be directly inferred from bulk sequence data. Well-defined, complete haplotypes at single-cell resolution are ideal for describing within-host population structure and unambiguously determining parasite diversity, transmission dynamics recent ancestry have not been analyzed on a large scale. We generated 485 near-complete genome sequences isolated fifteen P....
Abstract Laboratory cultivation of the malaria parasite Plasmodium falciparum has underpinned nearly all advances in malariology past 30 years. When freshly isolated clinical isolates are adapted to vitro culture mutations rapidly fix increasing growth rate and stability. While dynamics adaptation increasingly well characterized, we know little about extent genomic variation that arises spreads during long term culture. To address this cloned 3D7 reference strain maintained a for ~84 asexual...
Abstract Plasmodium falciparum is the most virulent and widespread of human malaria parasite species. This has a complex life cycle that involves sexual replication in mosquito vector asexual host. During 48-hour intraerythrocytic developmental (IDC), parasites develop multiply through morphologically distinct ring, trophozoite schizont stages. Stage-specific transcriptomic approaches have shown gene expression profiles continually change throughout IDC. Cultures tightly synchronized are...
Abstract Laboratory cultivation of the malaria parasite Plasmodium falciparum has underpinned nearly all advances in malariology past 30 years. When freshly isolated clinical isolates are adapted to vitro culture mutations rapidly fix increasing growth rate and stability. While dynamics adaptation increasingly well characterized, we know little about extent genomic variation that arises spreads during long term culture. To address this cloned 3D7 reference strain maintained a for ~84 asexual...
Population genomics of bulk malaria infections is unable to examine intrahost evolution, so most work has focused on the role recombination in generating genetic variation. We used a novel single cell sequencing protocol for low parasitemia generate 406 near complete P. vivax genomes from 11 patients sampled during sequential febrile episodes. Parasite contained hundreds de novo mutations, showing strong signatures selection, which are enriched ApiAP2 family transcription factors, known...
Malaria patients can carry one or more clonal lineage of the parasite, Plasmodium falciparum. Well-defined, complete haplotypes at single-cell resolution are ideal for describing within-host population structure and unambiguously determining parasite diversity, transmission dynamics recent ancestry but have not been analyzed on a large scale. We generated 485 near-complete genome sequences isolated from fifteen P. falciparum Chikhwawa, Malawi, an area intense malaria transmission. Matched...