A5103865354- Ubiquitin and proteasome pathways
- AI in Service Interactions
- Protein Degradation and Inhibitors
- Speech and dialogue systems
- Artificial Intelligence in Healthcare and Education
- Sirtuins and Resveratrol in Medicine
- Photonic Crystals and Applications
- Semiconductor materials and devices
- Plant Molecular Biology Research
- Protein Kinase Regulation and GTPase Signaling
- Cancer-related gene regulation
- Digital Marketing and Social Media
- Atmospheric aerosols and clouds
- Environmental Changes in China
- Quantum Dots Synthesis And Properties
- Particle accelerators and beam dynamics
- Atmospheric Ozone and Climate
- Digital Mental Health Interventions
- Plasmonic and Surface Plasmon Research
- Atmospheric and Environmental Gas Dynamics
- Biochemical and Molecular Research
- Remote Sensing and Land Use
- Peptidase Inhibition and Analysis
- Technology Adoption and User Behaviour
- Autophagy in Disease and Therapy
Liaocheng People's Hospital
2025
Nanjing University of Chinese Medicine
2023-2024
Chinese Academy of Sciences
2008-2024
Huazhong University of Science and Technology
2024
Shanghai Institute of Materia Medica
2023-2024
Xuzhou Medical College
2023
Nanjing Drum Tower Hospital
2023
Nanjing University
2023
University of Chinese Academy of Sciences
2016-2021
Changchun Institute of Optics, Fine Mechanics and Physics
2021
Background: Melanoma is a highly lethal form of skin cancer, and effective treatment remains significant challenge. SPP86 novel potential therapeutic drug. Nonetheless, the specific influence on autophagy, particularly its mechanisms in context DNA damage apoptosis human melanoma cells, inadequately understood. Thus, this study aims to explore effects autophagy elucidate association with cell proliferation, apoptosis, cells. Methods: This assessed anti-tumor viability, colony formation, two...
The use of small molecular modulators to target the guanine nucleotide exchange factor SOS1 has been demonstrated be a promising strategy for treatment various KRAS-driven cancers. In present study, we designed and synthesized series new inhibitors with pyrido[2,3-d]pyrimidin-7-one scaffold. One representative compound 8u showed comparable activities reported inhibitor BI-3406 in both biochemical assay 3-D cell growth inhibition assay. Compound obtained good cellular against panel KRAS...
Purpose Generative conversational artificial intelligence (AI) demonstrates powerful skills for general tasks but requires customization specific tasks. The quality of a custom generative AI highly depends on users’ guidance, which has not been studied by previous research. This study uses social exchange theory to examine how AI’s cognitive and emotional affect guidance through different types user engagement, these effects are moderated relationship norm orientation....
The mortality rates of gastric cancer remain high due to limited therapeutic strategies. As a highly selective inhibitor the BD2 domain BET family proteins, ABBV-744 has potent chemotherapeutic activity against various human solid tumors. However, whether potential anti-tumor effects in largely unknown. In this study, we evaluated effect on cells and explored possible underlying mechanisms. We found that inhibited growth patient-derived tumor organoids dose-dependent manner. Cellular...
Abstract Aluminum nitride (AlN) nanopowders have been synthesized by a novel method which combines the hydrothermal and carbothermal techniques. The phase of nitridation products can be controlled through adjusting carbon content precursor adding different amount urea (U). product from (U/Al=2) was comprised spherical well‐distributed particles with sizes ranging 50 to 100 nm. procedure investigated in detail TG / DSC , XRD TEM measurements. It found that core‐matrix structured Al 2 O 3 /C...
Rapid urbanization has resulted in great changes rural landscapes globally. Using remote sensing data to quantify the distribution of settlements and their received increasing attention past three decades, but remains a challenge. Previous studies mostly focused on residential within grid or administrative boundary, not at individual village level. This paper presents new change detection approach for settlements, which can identify different types settlement level by integrating Geographic...
A Hofmann rearrangement tailored and exfoliated multi-layered ammonia reduced graphene oxide into amine functionalized quantum dots.
We report a theoretical study of perfect absorber based on the metal-insulator-metal (MIM) structure, which achieves absorption single and double peaks in visible range. The top Ag middle SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> are arranged periodic nanopillar array. Adjusting structural parameters nanopillars to indirectly control spectrum, theoretically maximum single-peak can reach more than 99.0% double-peak 90.0%....
Essential genes are usually less likely to be lost during evolution, whereas dispensable more frequently. Integrating sacred lotus and other plant microRNA (miRNA) data, we found different ancient miRNA families that arose before eudicot radiation exhibit evolutionary trajectories. Those with higher copy target numbers, older age retained in descendants conserved (hairpin-structured) gene sequences. Interestingly, a large portion of the well lineages can transcription factors (TFs). Also,...
The lightning imager is one of the three main loads FY-4 Meteorological Satellite. It first optical remote sensing device for detection at high altitude in our country. runs on geostationary orbit, and technical index has reached international leading level. Aiming characteristics orbit detection, this paper analyzes methods detection. uses spectral features, time space differences between transient slowly changing clouds, land ocean background noise. signal detected by combining filtering,...