Being transgender is associated with numerous health disparities, and individuals face mistreatment discrimination in healthcare settings. At the same time, professionals report inadequate preparation to care for people, patients often have teach their own medical providers about care. Our study aimed evaluate impact of an elective course profession students that was implemented address these gaps provider knowledge.Students participated a 10-session, lunch-hour during spring 2015. To...

Lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI) individuals continue to face barriers accessing appropriate comprehensive healthcare. Compounding this problem, healthcare trainees report few training opportunities low levels of preparedness care for LGBTQI patients. In 2009, an interprofessional group students a faculty advisor at the University California, San Francisco, developed novel student-organized Health Forum medical, dental, pharmacy, nursing, physical therapy...

Both hormone therapy (HT) and antiretroviral (ART) can be lifesaving for transgender women (TW) living with HIV, but each has side effects potential drug-drug interactions (DDI). We assessed how concerns about HT-ART affect treatment adherence.This study used a cross-sectional survey of TW (n = 87) in Los Angeles, CA.Fifty-four percent were HIV; 64% HT. Only 49% HIV discussed ART-HT DDI their provider; 40% reported not taking ART (12%), HT or both (16%) as directed due to concerns.Imperfect...

There is a paucity of literature on the use dalbavancin, long-acting lipoglycopeptide, in infective endocarditis. Existing case reports have investigated dalbavancin endocarditis as sequential treatment after clearance bacteria from bloodstream with conventional therapy. A 27-year-old female who injects drugs presented fever and pleuritic chest pain was found to methicillin-sensitive Staphylococcus aureus tricuspid-valve septic pulmonary emboli. Given non-adherence therapy, she successfully...

Objectives People who inject drugs (PWID) may experience high human immunodeficiency virus (HIV) risk and inadequate access to biomedical HIV prevention. Emerging data support integrating post-exposure pre-exposure prophylaxis (PEP, PrEP) into services already accessed by PWID. We describe PEP/PrEP eligibility receipt in a low-barrier substance use disorder bridge clinic located an area experiencing outbreak among PWID at the onset of COVID-19 pandemic. Methods Retrospective chart review new...

Abstract Background Sublingual buprenorphine, approved for treatment of opioid use disorder since 2002, is most commonly available in co-formulation with naloxone. Naloxone an antagonist minimally absorbed when sublingual (SL) buprenorphine/naloxone taken as prescribed; it thought to reduce potential misuse via intravenous administration. However, growing data and clinical experience demonstrate that previously accepted assumptions about the pharmacokinetics these medications may not apply...

The antiretroviral efficacy of 3′-azido-3′-deoxythymidine (AZT) is dependent upon intracellular mono-, di-, and triphosphorylation incorporation into DNA in place thymidine. Thymidine kinase 1 (TK-1) catalyzes the first step this pathway. MOLT-3, human lymphoblastoid cells, were exposed to AZT continuously for 14 passages (P1–P14) cultured an additional (P15–P28) without AZT. Progressive irreversible depletion enzymatically active form TK-1 24-kDa monomer with loss protein was demonstrated...

A detailed understanding of intentions and practices related to partner notification (PN) following STI diagnosis can improve control strategies. We assessed participant-level partner-level factors guiding behaviour among men who have sex with and/or transgender women (MSM-TW) in Lima, Peru, including discordances between anticipated actual notification.Men newly diagnosed gonorrhoea, chlamydia syphilis 2012 2014 reported recent partners' characteristics, PN practices, outcomes diagnosis....

The cytokinesis-block micronucleus cytome (CBMN) assay, introduced by Fenech, was used to demonstrate different types of DNA damage in MOLT-3 human lymphoblastoid cells exposed 10 μM zidovudine (AZT). In addition, we explored the cytoprotective potential two antioxidants, WR-1065 and Tempol, decrease AZT-induced genotoxicity. Binucleated cells, arrested Cytochalasin B (Cyt B), were evaluated for micronuclei (MN), caused or chromosomal loss, chromatin nucleoplasmic bridges (NPBs), telomere...

<title>Abstract</title> <bold>Background</bold> Sublingual buprenorphine, approved for treatment of opioid use disorder since 2002, is most commonly available in co-formulation with naloxone. Naloxone an antagonist minimally absorbed when sublingual (SL) buprenorphine/naloxone taken as prescribed; it thought to reduce potential misuse via intravenous administration. However, growing data and clinical experience demonstrate that previously accepted assumptions about the pharmacokinetics these...

Expedited partner therapy involves prescribing sexually transmitted infection (STI) treatment for a patient's partner(s) without seeing the partner. It is approved heterosexual partners of patients with chlamydia in most states. However, Centers Disease Control and Prevention recommends against expedited men-who-have-sex-with-men (MSM), citing limited data this population concerns that could discourage comprehensive STI testing, thereby driving increased HIV transmission. In piece, we...

Objectives In the midst of opioid crisis, increasing attention has been given to assessing and addressing substance use disorders (SUDs) among transgender gender diverse (TGD) populations. As electronic health records begin more uniformly collect identity data, clinicians public professionals are better able examine prevalence SUDs receipt SUD treatment services in these Methods We utilized cross-sectional data from January 2005 December 2019 a large safety-net hospital Massachusetts. A...

Background Safer drinking strategies (SDS) reduce alcohol-related harms in outpatient settings. Little is known about SDS among hospitalized patients.

<h3>Introduction</h3> A detailed understanding of partner notification (PN) practices following STI diagnosis can improve PN strategies. Using data from 2 intervention trials in Lima, Peru, we assessed participant- and partner-level factors guiding partner-specific behaviour, including discordances between anticipated actual notification. <h3>Methods</h3> From 2012–14, newly STI-diagnosed (gonorrhoea, chlamydia, syphilis) men who have sex with (MSM) and/or transgender women Lima reported...

Abstract Background Buprenorphine is a partial µ-opioid agonist with high receptor binding affinity and long half-life—qualities that reduce overdose risk concomitant opioid use, though may precipitate withdrawal by displacing full agonists. Traditional buprenorphine induction typically requires patients endure moderate prior to initiation, challenges intensifying for transitioning from higher-dose methadone. Novel microinduction reports aim remove this prerequisite, significant limitations....