A5089312139- Hematopoietic Stem Cell Transplantation
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- RNA modifications and cancer
- Healthcare and Environmental Waste Management
- 3D Printing in Biomedical Research
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Additive Manufacturing and 3D Printing Technologies
- Bone Tissue Engineering Materials
- Lung Cancer Treatments and Mutations
- Pluripotent Stem Cells Research
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Cancer Cells and Metastasis
- Electrospun Nanofibers in Biomedical Applications
- Genetics and Neurodevelopmental Disorders
- Neuroblastoma Research and Treatments
- Lymphatic System and Diseases
- Immune cells in cancer
- Immune Cell Function and Interaction
- Pituitary Gland Disorders and Treatments
University of Lausanne
2022-2024
École Polytechnique Fédérale de Lausanne
2023-2024
University of Wisconsin–Madison
2024
Universitat de Barcelona
2024
Leibniz University Hannover
2021
Duke University
2020
Abstract Despite advances in biomaterials research, there is no ideal device for replacing weight‐bearing soft tissues like menisci or intervertebral discs due to poor integration with and mechanical property mismatch. Designing an implant a porous tissue‐contacting structure using material conducive cell attachment growth could potentially address these limitations. Polycarbonate urethane (PCU) tough biocompatible that can be 3D printed into structures controlled pore sizes. Porous of...
Aging is the major risk factor for most human diseases and represents a socio-economical challenge modern societies. Despite its importance, process of aging remains poorly understood. Epigenetic dysregulation has been proposed as key driver process. Modifications in transcriptional networks chromatin structure might be central to age-related functional decline. A prevalent feature described during overall reduction heterochromatin, specifically marked by loss repressive histone...
Abstract Adult hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow (BM) niche, which regulates HSPC quiescence, self-renewal, commitment a demand-adapted manner. Although complex BM niche is responsible for adult hematopoiesis, evidence exists simpler, albeit functional more accessible, extramedullary niches. Inspired by anecdotal description of retroperitoneal masses occurring at higher frequency upon hormonal dysregulation within adrenal gland, we hypothesized that...
The gut is an emerging regulator of bone marrow (BM) hematopoiesis and several signaling molecules are involved in this communication. Among them, bile acids (BAs), originally classified as lipid solubilizers, have emerged powerful that act a relay between the digestive system, microbiota rest body. function BAs relies on specific receptors, including Takeda-G-protein-receptor-5 (TGR5). TGR5 has potent regulatory effects immune cells, but its effect BM primary organ remains unknown. Here, we...
The gut is an emerging regulator of bone marrow (BM) hematopoiesis and several signaling molecules are involved in this communication. Among them, bile acids (BAs), originally classified as lipid solubilizers, have emerged powerful that act a relay between the digestive system, microbiota rest body. function BAs relies on specific receptors, including Takeda-G-protein-receptor-5 (TGR5). TGR5 has potent regulatory effects immune cells, but its effect BM primary organ remains unknown. Here, we...
Abstract Hematopoietic Stem and Progenitor Cells (HSPCs) reside in the hematopoietic niche, a structure that regulates balance of cellular quiescence, self-renewal commitment demand-adapted manner. The bone marrow (BM) niche is formed by several players, mainly endothelial cells, osteoblasts, adipocytes, stromal cells. While BM forms complex structure, evidence exists for simpler, albeit functional, extramedullary niches. However, composition what constitutes simplest unit an HSPC supportive...
<title>Abstract</title> Aging is the major risk factor for most human diseases and represents a socio-economical challenge modern societies. Despite its importance, process of aging remains poorly understood. Epigenetic dysregulation has been proposed as key driver process. Alterations in transcriptional networks chromatin structure might be central to age-related functional decline. A prevalent feature described during overall reduction heterochromatin, specifically marked by loss...
Abstract The gut is an emerging regulator of bone marrow (BM) hematopoiesis and several signaling molecules are involved in this communication. Among them, bile acids (BAs), originally classified as lipid solubilizers, have emerged powerful that act a relay between the digestive system, microbiota rest body. function BAs relies on specific receptors, including Takeda-G-protein-receptor-5 (TGR5). TGR5 has potent regulatory effects immune cells, but its effect BM primary organ remains unknown....