A5058381899- Drug Transport and Resistance Mechanisms
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Pharmacogenetics and Drug Metabolism
- Dialysis and Renal Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Hemodynamic Monitoring and Therapy
- Nitric Oxide and Endothelin Effects
- Cardiomyopathy and Myosin Studies
- Metabolism, Diabetes, and Cancer
- Clinical practice guidelines implementation
- Inflammasome and immune disorders
- COVID-19 and healthcare impacts
- Uterine Myomas and Treatments
- Muscle Physiology and Disorders
- Angiogenesis and VEGF in Cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Endometriosis Research and Treatment
- Medical and Biological Ozone Research
- Global Cancer Incidence and Screening
- Pharmacological Effects and Toxicity Studies
- Central Venous Catheters and Hemodialysis
- S100 Proteins and Annexins
- Cancer Risks and Factors
- Cholesterol and Lipid Metabolism
Ryazan State Medical University named after Academician I.P. Pavlov
2017-2024
Ulyanovsk State Technical University
2016
The aim of this work was to evaluate the relationship between concentration TGF-1 and activity cathepsins in vascular wall homogenates patients with varicose veins lower extremities at different stages disease according CEAP classification. homogenate determined by sandwich ELISA on a StatFax 2100 enzyme immunoassay analyzer (microplatereader) (Awareness technology Inc. Palm City, FL 34990, USA). results were expressed pg/ml. B, L H using Barrett Kirschke spectrofluorimetric method Shimadzu...
Endothelial cells are the inner lining of arteries, veins, capillaries, and lymphatic vessels. They play an important role in biochemical processes, providing tissue respiration metabolism. Their metabolic rate depends on speed blood flow, due to fact that they located border between tissues. In other words, hemodynamic factors determine mechanisms interaction endotheliocytes with cell types affect formation endothelial phenotype, ability express various sets molecules, including adhesion,...
Aim: to characterize patients with new-onset AF associated/not associated chronic non-communicable diseases, and evaluate levels of biological markers myocardial fibrosis, as well significant clinical outcomes. Materials Methods: 128 atrial fibrillation including 50 subjects without severe diseases 78 were enrolled in the study. Complaints medical history recorded. Laboratory tests fibrosis (transforming growth factor beta (TGF-β), galectin 3), ECG, EchoCG performed. Adverse outcomes...
INTRODUCTION: A new coronavirus infection (NCI) is characterized by catastrophic coagulopathy with development of thrombotic and hemorrhagic complications. The choice an optimal anticoagulant in these patients remains important issue.
 AIM: To evaluate risk factors for venous thromboembolic complications (VTEC), effectiveness safety different variants therapy (ACT) NCI.
 MATERIALS AND METHODS: prospective study was conducted that involved 370 NCI: group 1 who received low molecular...
INTRODUCTION: Endometriosis is a common disease that affects up to 15% of women in the reproductive period and leads infertility 25%–50% cases. The diagnosis endometriosis delayed for years due blurred diverse clinical presentation, therefore, search noninvasive biomarker an important problem modern medicine. AIM: To study significance changes profile biomarkers: regulator Wnt/β-catenin signaling pathway (axis inhibition protein 1; AXIN-1), soluble cytokeratin 19 fragment (cytokeratin...
INTRODUCTION: The physical inactivity, hypoventilation, as well chronic inflammation in obese patients aggravates their condition various diseases. These features have become important with the advent of COVID-19 pandemic, which and platelet-activated coagulopathy are closely linked. AIM: To study laboratory parameters platelet apoptosis using types anticoagulant prophylaxis venous thromboembolic complications underlying COVID-19. MATERIALS AND METHODS: included 370 Depending on presence or...
INTRODUCTION: The current stage of development dental implantology permits to perform a complete rehabilitation even in complicated clinical situations. However, there are some difficulties which prevent achievement high success implantological treatment certain somatic pathologies that manifest the form systemic inflammation, and present relative contraindications for implantation. Important general include chronic obstructive pulmonary disease, atherosclerosis, non-insulin-dependent...
Обоснование.Проблема лечения больных с терминальной стадией хронической почечной недостаточности обусловлена постоянно растущим количеством пациентов, нуждающихся в программном гемодиализе и высокой частоте осложнений, связанных функционированием постоянного сосудистого доступа.В настоящее время нет идеального доступа для гемодиализа.Основными причинами, которые приводят к прекращению его функционирования необходимости выполнения повторных операций являются развитие стенозов артериовенозных...
BACKGROUND: COVID-19 is associated with inflammation and extensive changes in hemostasis. This study aimed at evaluating levels of inflammatory markers MCP1 IP 10 patients undergoing anticoagulant therapy.METHODS: A prospective cohort included 370 who received different types anticoagulants: group 1 - low molecular weight heparins (LMWH), 2 unfractionated heparin (UFH), 3 direct oral anticoagulants (DOACs). All subjects underwent physical examination, basic laboratory testing evaluation...
INTRODUCTION: The role of genetic factors in the development cardiovascular diseases (CVD) patients with inflammatory bowel (IBD) is practically unknown.
 AIM: To study frequency carriage allelic polymorphous variants NOD2/CARD15 (3020insC rs5743293, Gly908Arg rs2066845), CRP (+1444CT rs1130864), FTO (A23525T rs9939609) genes and to perform a comprehensive assessment damage target organs, diastolic myocardial dysfunction left ventricle CVD ulcerative colitis Crohn’s disease living...
Introduction. PSGL-1 is a complex protein, that provides contacts between blood cells and endothelial by connecting with cell-adhesion mole-cules selectins, it universal participant in the processes of leukocyte adhesion, inflammation immune response. The study possible regulation its functioning an urgent topic, since process interactions selectins can be point therapeutic application. Aim study. Evaluation relationship concentration ligand PSGL-1, inducible (iNOS) (eNOS) NO synthases final...
Цель - изучение функциональной активности белка-транспортера гликопротеина-Р (Pgp) при овариоэктомии и последующем введении эстрадиола в эксперименте in vivo . Методика. Исследование выполнено на 23 кроликах-самках Шиншилла массой 4300-4700 г. 1-я группа ложнооперированные животные, 2-я овариоэктомия, кроликам 3-й 4-й групп с 15-х сут. после перорально вводили эстрадиол дозах 0,5 мг 2 мг, соответственно. За 7 до начала исследования, 14-е, 28-е 42-е оперативного вмешательства у всех животных...
Muscular dystrophies are one of the most pressing problems modern medicine. In electronic library system e-Library on topic “Muscular Dystrophies” 13,263 papers have been published, over past 5 years — 4,221, and in PubMed, at request Dystrophy”, more than 37 thousand publications found, there about 6,851. The interest this problem is understandable, since prevalence progressive muscular 200 cases per 1 000,000 population, which permits to classify them as common forms hereditary pathology....
The work suggests a mathematical model of thermal interaction workpiece and cutting tool when drilling. is based on simultaneous solution heat conduction equations the interacting bodies with general boundary condition in contact zone. paper gives results modeling research processing errors connected deformations, which under drilling group holes allows rationalizing sequence. Efficiency ultrasound technology cooling liquid supply zone shown.
В статье представлены результаты изучения особенностей артериальной гипертензии и нарушения функции эндотелия у больных сахарным диабетом 1 2 типа в сочетании с первичным гипотиреозом. Выявлено увеличение индекса времени диастолического артериального давления нарушение суточного ритма преобладанием профиля нон-диппер, отмечено снижение эндотелий-зависимой вазодилатации повышение концентрации эндотелина-1. Обнаружена корреляция параметров показателями углеводного, липидного обмена, давления,...
INTRODUCTION: In the large studies such as NASCET, ESCT, VACS, ACAS and ACST-1, role of alteration cognitive functions a patient in early long-term postoperative periods have not been determined.
 AIM: To evaluate biochemical parameters cerebral functions, status patients, their interrelation after carotid endarterectomy.
 MATERIALS AND METHODS: The study involved 60 patients divided into two groups. mean age was 67.3 ± 7.9 years, there were 49 (81%) men 19 (19%) women. Group A...
Comorbid pathology is important in the survival of patients with breast cancer. The main aim present study was to investigate prognostic criteria 5-year menopausal women cancer, including both classic (age, tumor size, lymph node status, hormonal status) and presence comorbid (arterial hypertension, visceral obesity, diabetes mellitus, metabolic syndrome, immunodeficiency). A prospective cohort included 98 cancer (aged 63 ± 9 years, BMI 31.6 4.8 kg/m2). Criteria favorable short-term (5...
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INTRODUCTION: Vildagliptin is one of the drugs choice in treatment type 2 diabetes mellitus (DM). In literature review, no study has reported effect vildagliptin on expression level transporter protein P-glycoprotein (P-gp, ABCB1 protein).
 AIM: To assess vivo effects Р-gp normal conditions and experimental alloxan-induced DM.
 MATERIALS AND METHODS: Type DM was induced by a single intravenous injection freshly prepared alloxan monohydrate solution citrate buffer (pH = 4.0) at dose...