A5075747573- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Supramolecular Chemistry and Complexes
- Advanced Polymer Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Bacteriophages and microbial interactions
- Molecular Junctions and Nanostructures
- Enzyme Catalysis and Immobilization
- Mass Spectrometry Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Supramolecular Self-Assembly in Materials
- Monoclonal and Polyclonal Antibodies Research
- biodegradable polymer synthesis and properties
- Curcumin's Biomedical Applications
- Proteins in Food Systems
- Membrane Separation and Gas Transport
- Analytical chemistry methods development
- Protein purification and stability
- Micro and Nano Robotics
Max Planck Institute for Polymer Research
2024
University of Münster
2019-2021
Nanocapsules enable multicomponent encapsulation of therapeutic cargoes with high content and efficiency, which is vital for cancer immunotherapy. In the past, chemical crosslinking used to synthesize nanocapsules, can impede regulatory approval process. Therefore, a new class protein nanocapsules developed by eliminating need utilizing denaturation through process that referred as "baking at droplet interface". Such antigens incorporated in shell combination encapsulated drugs showed an...
The transport of membrane impermeable compounds into cells is a prerequisite for the efficient cellular delivery hydrophilic and amphiphilic drugs. Transport cell's cytosolic compartment should ideally be controllable it involve biologically compatible degradable vehicles. Addressing these challenges, nanocontainers based on cyclodextrin amphiphiles that are stabilized by biodegradable peptide shell developed their potential to deliver fluorescently labeled cargo human analyzed. Host-guest...
Abstract Trägersysteme für den Transport in das Zellinnere sind notwendig, um Einschränkungen klassischer Therapeutika, wie geringe Spezifität, systemische Toxizität, zu hohe Freisetzungsraten sowie therapeutische Indices, überwinden können. Nanocontainer aus einem wassergefüllten Kern und einer Polymerhülle dabei von besonderem Interesse, da sie die Möglichkeiten stimuligesteuerter Frachtfreisetzung gezielter Oberflächenmodifikation zur Erhöhung der lokalen Selektivität kombinieren. Dieser...
Supramolecular nanogels are an emerging class of polymer nanocarriers for intracellular delivery, due to their straightforward preparation, biocompatibility, and capability spontaneously encapsulate biologically active components such as DNA. A completely biodegradable three-component cationic supramolecular nanogel was designed exploiting the multivalent host-guest interaction cyclodextrin adamantane attached a polypeptide backbone. While conjugated linear poly-L-lysine, grafted well star...
Biodegradable supramolecular micelles were prepared exploiting the host-guest interaction of cyclodextrin and adamantane. Cyclodextrin-initiated polypeptides acted as hydrophilic corona, whereas adamantane-terminated polycaprolactones served hydrophobic core.
Abstract The synthesis of adamantane‐terminated polypeptides by N ‐carboxyanhydride (NCA) polymerization and their use in the template‐based self‐assembly redox‐responsive nanocontainers is described. Cyclodextrin vesicles (CDV) serve as a supramolecular template to anchor adamantane terminated on surface CDV form polypeptide shelled (PPSVss) which are stabilized crosslinking with cystamin. Polypeptides characterized nuclear magnetic resonance, matrix‐assisted laser desorption/ionization...
The present study demonstrates that albumin-coated drug nanocrystals represent a highly efficacious novel approach for the controlled intracellular release of drugs with limited solubility in immune cells.
Surface modification of nanoparticles involves numerous types active molecules such as DNA, antibodies, enzymes or carbohydrates.
Dual-Responsive Nanocontainers In article number 2100694, Bart Jan Ravoo, Volker Gerke, and co-workers design nanocontainers based on cyclodextrin amphiphiles that are stabilized by a peptide shell redox-responsive crosslinker. These dual-responsive represent an efficient, biodegradable, tunable system for overcoming the plasma membrane as natural barrier membrane-impermeable cargo. The was conceived Sergej Kudruk composed Nina Knubel at University of Münster.