A5101612287- Pancreatic function and diabetes
- Sulfur Compounds in Biology
- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Erythropoietin and Anemia Treatment
- Plant Disease Management Techniques
- Organ Transplantation Techniques and Outcomes
- Plant-Microbe Interactions and Immunity
- Cardiac Arrest and Resuscitation
- Plant Pathogens and Fungal Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diabetic Foot Ulcer Assessment and Management
- Alcoholism and Thiamine Deficiency
- Pain Management and Treatment
- Circular RNAs in diseases
- PARP inhibition in cancer therapy
- Chronic Kidney Disease and Diabetes
- Blood properties and coagulation
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Adenosine and Purinergic Signaling
- Anesthesia and Pain Management
Kyoto first Red Cross hospital
2018
Massachusetts General Hospital
2014-2018
Harvard University
2014
Pain and Rehabilitation Medicine
2014
Washington State University
2014
The University of Tokyo
2014
Kyoto Prefectural University of Medicine
2006
Okayama University
2004
University of Alberta
2004
Kyushu University
1990
Local anesthetics suppress proliferation in several cancer cells. The mechanism of the suppression, however, is unknown. Our previous study shows that lidocaine, at level tissue concentration under topical or local administration, has a direct inhibitory effect on activity epidermal growth factor receptor (EGFR), which potential target for antiproliferation Therefore, we hypothesized lidocaine would cells through inhibition EGFR activity. We investigated effects (40-4000 microM) human tongue...
Acute lung injury is characterized by neutrophilic inflammation and increased permeability. Thiosulfate a stable metabolite of hydrogen sulfide, gaseous mediator that exerts antiinflammatory effects. Although sodium thiosulfate (STS) has been used as an antidote, the effect STS on acute unknown. The authors assessed effects mice vascular endothelial cells subjected to inflammation.Lung was in challenged with intratracheal lipopolysaccharide or cecal ligation puncture without STS. Effects...
Adipose tissue is no longer considered a passive energy store. Instead, it well established as an important endocrine contributor. Here, the authors comprehensively show that function of adipose organ not limited to classical adipokines, but also includes miRNAs and maybe other non-coding RNAs. This study indicates main source circulating miRNAs, only in mice humans. They dissected role different depots showed derived operate manner distant tissues, such liver. In summary, for first time...
Hydrogen sulfide (H<sub>2</sub>S) exerts a host of biological effects ranging from cytotoxicity to cytoprotection.
An immortalized human hepatocyte cell line (OUMS-29) was established from fetal liver by transfection with the SV-40 large T antigen gene that has certain liver-specific functions such as albumin production and enzyme activities of CYP1A1, 1A2, 2E1. To make OUMS-29 cells express other functions, nuclear factor 4alpha2 (HNF4alpha2) introduced into cells, because this found to be markedly down-regulated. The transduced HNF4alpha2 overexpressed in nuclei transfected its DNA-binding activity...
Anesthetic management of lower extremity amputation in chronic hemodialysis (HD) patients can be challenging because their poor cardiovascular status. As previously reported, peripheral nerve block (PNB) may beneficial these complicated cases. We report the effects PNB combined with general anesthesia on hemodynamic stability HD undergoing elective amputation.We retrospectively analyzed 13 who underwent amputation. Patients received (GA group, n = 7) or 6), as decided by anesthesiologists....
P1174 Aims: It is of extreme importance to establish human pancreatic islet cell lines, especially beta lines develop diabetes-targeted therapies. In the present study, we have established an immortalized line using a retroviral transduction simian virus 40 large T antigen (SV40T) and telomerase reverse transcriptase (hTERT). Methods: Human islets were isolated defined protocols enzymatic dissociation purification discontinuous gradients Ficoll refrigerated Cobe 2991 machine. The resulting...