A5031674174- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Fungal and yeast genetics research
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- bioluminescence and chemiluminescence research
- Viral Infectious Diseases and Gene Expression in Insects
- ATP Synthase and ATPases Research
- Pharmacological Receptor Mechanisms and Effects
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Neurotransmitter Receptor Influence on Behavior
- CRISPR and Genetic Engineering
- Microtubule and mitosis dynamics
Centre de Biophysique Moléculaire
2010-2023
Centre National de la Recherche Scientifique
2010-2023
Inserm
2019
Université d'Orléans
2019
Centre de Génétique Moléculaire
2010
The production of mature export-competent transcripts is under the surveillance quality control steps where aberrant mRNP molecules resulting from inappropriate or inefficient processing and packaging reactions are subject to exosome-mediated degradation. Previously, we have shown that heterologous expression bacterial Rho factor in yeast interferes normal biogenesis leading full-length yet degraded by nuclear exosome with ensuing growth defect. Here, took advantage this new tool investigate...
Gliomas account for 50% of brain cancers and are therefore the most common tumors. Molecular alterations involved in adult gliomas have been identified mainly affect tyrosine kinase receptors with amplification and/or mutation epidermal growth factor receptor (EGFR) its associated signaling pathways. Several targeted therapies developed, but current treatments remain ineffective glioblastomas, severe forms. Thus, it is a priority to identify new pharmacological targets. Drosophila glioma...
Significance Transmembrane signaling through G protein–coupled receptors (GPCRs), originally described as requiring coupling to intracellular proteins, also uses protein–independent pathways β-arrestin recruitment. Biased ligands, by favoring one of the multiple bioactive conformations GPCRs, allow selective either these pathways. Here, we identified Serodolin first β-arrestin–biased agonist serotonin 5-HT 7 receptor. This new ligand, while acting an inverse on s signaling, selectively...
Gliomas are the most common primary brain tumors in adults. Significant progress has been made recent years identifying molecular alterations involved gliomas. Among them, an amplification/overexpression of EGFR (Epidermal Growth Factor Receptor) proto-oncogene and its associated signaling pathways have widely described. However, current treatments remain ineffective for glioblastomas, severe forms. Thus, identification other pharmacological targets could open new therapeutic avenues. We...
The co-transcriptional biogenesis of export-competent messenger ribonucleoprotein particles (mRNPs) in yeast is under the surveillance quality control (QC) steps. Aberrant mRNPs resulting from inappropriate or inefficient processing and packaging reactions are detected by QC system retained nucleus with ensuing elimination their mRNA component a mechanism that requires catalytic activity Rrp6p, 3'-5' exonuclease associated RNA exosome. In previous studies, we implemented new experimental...
The eukaryotic THO complex coordinates the assembly of so-called messenger RNA–ribonucleoprotein particles (mRNPs), a process that involves cotranscriptional coating nascent mRNAs with proteins. Once formed, mRNPs undergo quality control step marks them either for active transport to cytoplasm, or Rrp6/RNA exosome-mediated degradation in nucleus. However, mechanism behind is still unclear. We investigated budding yeast by expressing bacterial Rho helicase, which globally perturbs mRNP...