A5037135784- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Molecular Sensors and Ion Detection
- Malaria Research and Control
- Nanocluster Synthesis and Applications
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Advanced NMR Techniques and Applications
- Mosquito-borne diseases and control
- Stress Responses and Cortisol
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Down syndrome and intellectual disability research
- Hypothalamic control of reproductive hormones
- Electron Spin Resonance Studies
- Neuroendocrine regulation and behavior
- Kruppel-like factors research
- Quantum Dots Synthesis And Properties
- Genomic variations and chromosomal abnormalities
- Characterization and Applications of Magnetic Nanoparticles
- Crystallography and molecular interactions
- Elasticity and Material Modeling
- TGF-β signaling in diseases
- Dendrimers and Hyperbranched Polymers
Centre National de la Recherche Scientifique
2013-2024
Centre de Biophysique Moléculaire
2015-2024
Robert Bosch (Germany)
2024
Université d'Orléans
2015-2024
University of Puerto Rico at Carolina
2015-2018
Laboratoire de Physique et Chimie de l’Environnement et de l’Espace
2001
Laboratoire Chimie de l'Environnement
2001
Reproduction induces changes within the brain to prepare for gestation and motherhood. However, dynamic of these central their relationships with development maternal behavior remain poorly understood. Here, we describe a longitudinal morphometric neuroimaging study in female mice between pre-gestation weaning, using new magnetic resonance imaging (MRI) resources comprising high-resolution template, its associated tissue priors (60-µm isotropic resolution) corresponding mouse atlas (1320...
Applying a single molecular probe to monitor enzymatic activities in multiple, complementary imaging modalities is highly desirable ascertain detection and avoid the complexity associated with use of agents different chemical entities. We demonstrate here versatility lanthanide (Ln
Molecular magnetic resonance imaging (MRI) approaches that detect biomarkers associated with neural activity would allow more direct observation of brain function than current functional MRI based on blood-oxygen-level-dependent contrast. Our objective was to create a synthetic molecular platform appropriate recognition moieties for zwitterionic neurotransmitters generate an MR signal change upon neurotransmitter binding. The gadolinium complex (GdL) we report offers ditopic binding amino...
We report first prototypes of responsive lanthanide(III) complexes that can be monitored independently in three complementary imaging modalities. Through the appropriate choice cations, same reactive ligand used to form providing detection by (i) visible (Tb3+) and near-infrared (Yb3+) luminescence, (ii) PARACEST- (Tb3+, Yb3+), or (iii) T1-weighted (Gd3+) MRI. The use ions different natures for these modalities induces only a minor change structure are therefore expected have single...
Cerebral malaria is a severe complication of Plasmodium falciparum infection. Although T-cell activation and type II IFN-γ are required for berghei ANKA (PbA)-induced murine experimental cerebral (ECM), the role I IFN-α/β in ECM development remains unclear. Here, we address pathway devel-opment response to hepatic or blood-stage PbA infection, using mice deficient types IFN receptors. While IFN-γR1⁻/⁻ were fully resistant, IFNAR1⁻/⁻ showed delayed partial protection after resistance...
Abstract A Th1 response is required for the development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (ECM). The role pro-Th1 IL-12 in complex and controversial. In this study, we addressed IL-12Rβ2 ECM development. C57BL/6 mice deficient IL-12Rβ2, IL-12p40, or IL-12p35 were analyzed after blood-stage PbA infection terms ischemia blood flow by noninvasive magnetic resonance imaging angiography, T cell recruitment, gene expression. Without no neurologic sign developed...
Abstract We have developed new methods enabling in vivo localization and identification of metabolites through their 1 H NMR signatures, a drosophila. Metabolic profiles localized regions were obtained using HR-MAS Slice Localized Spectroscopy Chemical Shift Imaging at high magnetic fields. These enabled measurement metabolite contents anatomic the fly, demonstrated by decrease β-alanine signals thorax flies showing muscle degeneration.
At present, there is a lack of well-validated protocols that allow for the analysis mechanical properties muscle and tendon tissues. Further, are no reports regarding characterization mouse skeletal in vivo using elastography thereby limiting ability to monitor changes these tissues during disease progression or response therapy. Therefore, we sought develop novel musculotendinous atomic force microscopy (AFM) ultrasound elastography. Given TIEG1 knockout (KO) mice exhibit well characterized...
A bioinspired probe based on a zinc finger peptide functionalized by lanthanide(iii)-DOTA monoamide complex turns out to be active for both luminescence and MRI detection of Zn2+, depending the lanthanide cation. mechanism MRI-based is proposed.
Novel magneto-plasmonic nanoprobes were designed for multimodal diagnosis of cancer by combination magnetic resonance imaging (MRI), surface-enhanced Raman scattering (SERRS), and fluorescence emission in the very near infrared (VNIR). A controlled electrostatic assembly silver nanoparticles (AgNPs), superparamagnetic iron oxide (SPIONs), VNIR dye Nile Blue (NB), biopolymer chitosan (Chi) was used to formulate AgIONs-Chi nanoprobes. The formulation protocol did not involve organic solvents...
Abstract Aim Tieg1 is involved in multiple signalling pathways, human diseases, and highly expressed muscle where its functions are poorly understood. Methods We have utilized knockout (KO) mice to identify novel important roles for this transcription factor regulating ultrastructure, metabolism mitochondrial the soleus extensor digitorum longus (EDL) muscles. RNA sequencing, immunoblotting, transmission electron microscopy, MRI, NMR, histochemical function assays were performed. Results...
Drug-loaded liposomes are typical examples of nanomedicines. We show here that doxorubicin, the anti-cancer agent in liposomal drug Doxil, can sensitize Ytterbium (Yb3+ ) and generate its near-infrared (NIR) emission. When doxorubicin amphiphilic Yb3+ chelates incorporated into liposomes, sensitized emission is dependent on integrity particles, which be used to monitor release. also established first demonstration NIR signal observable living mice following intratumoral injection...
Surface PEGylation of nanoparticles designed for biomedical applications is a common and straightforward way to stabilize the materials in vivo administration increase their circulation time. This strategy becomes less trivial when MRI active porous nanomaterials are concerned as function relies on water/proton-exchange between pores bulk water. Here we present comprehensive study effects relaxometric properties nanozeolite LTL (dimensions 20 × 40 nm) ion-exchanged with paramagnetic GdIII...
Gliomas account for 50% of brain cancers and are therefore the most common tumors. Molecular alterations involved in adult gliomas have been identified mainly affect tyrosine kinase receptors with amplification and/or mutation epidermal growth factor receptor (EGFR) its associated signaling pathways. Several targeted therapies developed, but current treatments remain ineffective glioblastomas, severe forms. Thus, it is a priority to identify new pharmacological targets. Drosophila glioma...
Abstract Applying a single molecular probe to monitor enzymatic activities in multiple, complementary imaging modalities is highly desirable ascertain detection and avoid the complexity associated with use of agents different chemical entities. We demonstrate here versatility lanthanide (Ln 3+ ) complexes respect their optical magnetic properties potential for NIR luminescence, CEST T1 MR imaging, controlled by nature Ln ion, while using unique chelator. Based on X‐ray structural,...
The type of surfactant and the nature dispersed continuous phases forming a miniemulsion, control size chemical composition Ln-based nanoparticles.
In the present study we investigated structural and metabolic modifications of brain in Ts65Dn mouse model Down syndrome(DS)using both vivo magnetic resonance imaging(MRI)and proton spectroscopy(MRS). MRI was performed for further texture analysis changes parameters, including mean grey levels, contrast homogeneity, they were found compared to diploid littermates (2n). These phenotypic different hippocampus cerebellum, since levels increased cerebellum decreased hippocampus. addition, NMR...
The MRI efficacy of the zinc finger peptide is greatly increased upon binding thanks to a combination reversible phosphoserine Gd 3+ and rigidity. This versatile system highly sensitive small amino acid changes.
Abstract Reproduction induces changes within the brain to prepare for gestation and motherhood. However, dynamic of these central their relationships with development maternal behavior remain poorly understood. Here, we describe a longitudinal morphometric neuroimaging study in female mice between pre-gestation weaning, using new magnetic resonance imaging (MRI) resources comprising high-resolution template, its associated tissue priors (60-μm isotropic resolution) corresponding mouse atlas...