Abstract A new difference spectrophotometric method for the determination of prothipendyl hydrochloride in commercial pharmaceutical preparations has been proposed. The includes oxidation an aliquot drug solution with potassium caroate to form corresponding sulfoxide ( ε = (5.83 ± 0.07) × 10 3 L/mol cm) and subsequent measurement absorbance at 340 nm compared that unoxidized equal concentration. graph Beer’s law shows Δ values measured wavelength are proportional concentration range 1.5–70...

Abstract Metopimazine (MPZ) is a dopamine antagonist from the phenothiazine class of drugs. It has antiemetic properties and used to treat nausea vomiting, including those associated with cancer chemotherapy. We have proposed new method for quantitative determination by spectrophotometry. The drug determined using difference spectrophotometric technique based on absorbance its previously prepared sulfoxide derivative ( λ max = 355 nm, ε 4.5 × 10 3 L/mol cm) relative solution non-derivatised...

The electrochemical behaviour of hydrogen peroxide (H2O2) has been studied using the alternating current voltammetry with square wave modulation in potential range +1.0…–1.0 V on carbositall electrode as a working and auxiliary (vs Ag,AgCl/KCl(sat)). peak was obtained at Ep = +0.16 background 0.1 Mol L–1 Na2SO4 0.01 KHSO4 (pH≈2.4) its height rising proportionally to increase H2O2 concentrations. linear dependence observed concentration (1.7-10.2)×10–5 L–1, calibration curve equation Ip...

A simple, rapid and sensitive voltammetric method for determining Metopimazine (MPZ) as its sulfoxide was developed. The derivative (MPZO) is formed quickly quantitatively at room temperature by adding potassium caroate solution. Well-defined cathodic waves were obtained MPZO in 0.02 mol/L HCl using the differential-pulse mode hanging mercury drop electrode (HMDE). It shown that limiting stage of reduction process adsorption on surface. Factors affecting peak current studied optimised....

Abstract A procedure for the chemiluminescence determination of Na-luminolate (NaHL) was developed. It is based on oxidation luminol with diperoxysuccinic acid (DPSA) in an alkaline solution (pH 10.3). At concentrations DPSA 5.8 × 10 –4 mol/L and NaHL range from 1.5 –7 to 1.02 –6 at pH 10.3 (in phosphate buffer solution), I max proportional c (NaHL): = (2.76 ± 0.30) 7 + (0.34 1.78) (r 0.998). LOD 6.10 –8 mol/L; LOQ 2.03 mol/L. The procedures were developed, possibility quantitative...

The kinetics of the oxidation reaction Lincomycin hydrochloride (Link) with potassium hydrogen peroxomonosulfate (KHSO5) was studied depending on pH medium. It has been established that obeys general laws specific acid-base catalysis. KHSO5 reacts quantitatively Link in an alkaline medium to form corresponding sulfone-N-oxide: 1 mole requires 3 moles KHSO5. Methods for oxidimetric determination were developed using as analytical reagent: a known excess reagent is added and after specified...

A new difference spectrophotometric method for the analysis of prothipendyl hydrochloride in commercial pharmaceutical preparations has been proposed. The includes oxidation an aliquot drug solution with potassium caroate to form corresponding sulfoxide (ε278 = (13.69 ±0.01)×103 L mol/cm) and subsequent measurement optical density at 278 nm compared that unoxidized equal concentration. graph Beer's law shows ΔA values measured wavelength are proportional concentration range 3.2-60 µg/mL....

To develop two (titrimetric and spectrophotometric) simple, rapid, sensitive cost-effective methods for the determination of metoclopramide (MCP) in pharmaceutical dosage forms.The titrimetric method (A) was based on N-oxidation reaction involving use potassium hydrogen peroxymonosulfate subsequent iodometric back titration a known residual reagent. The spectrophotometric (B) derivatization MCP with presence iodide to produce chromogen (triiodide) wavelength maximum absorption at 350...

Aim. To develop the method for quantitative determination of azlocillin.Materials and methods. The study object was Securopen® – a powder azlocillin (Azl) sodium in vials preparation solution injections (Azlocillin, 1.0 g). Peroxomonosulfate acid as triple potassium salt 2КНSO5 ∙ КНSO4 K2SO4 (Oxone®) “extra pure” qualification used an oxidant.Results discussion. kinetics conjugated reactions S-oxidation perhydrolysis Azlocillin with peroxomonosulfate alkaline medium has been studied by...

The oxidative derivatization method using Diperoxyazelaic acid for the indirect spectrophotometric determination of Levomepromazine hydrochloride is presented. introduced as a derivatizing agent Levomepromazine, yielding sulfoxides. This reaction product was successfully used hydrochloride. UV spectroscopic detection sulfoxide proved to be more robust and sensitive method. elaborated allowed in concentration range 3-150 µg/mL. limit quantification, LOQ (10S) 2.85 A new technique developed...

Topicality. Сlemastine fumarate (tavegil)-1-methyl-2 [2-α-methyl-p-chlorobenzhydryloxy)-ethyl]-pyrrolidine is the first generation H1-histamine receptor blocker. selectively inhibits histamine H1 receptors and reduces capillary permeability. The drug has a pronounced anti-allergic antipruritic effect. Clemastine prevents development of vasodilation smooth muscle contraction induced by histamine. an isignificant anticholinergic activity, causes sedation. used to treat pruritus in psoriasis,...

The electrochemical behaviour of potassium hydrogenperoxomonosulfate (KHSO5) at carbositall and Au, Ag electrodes using the square-wave voltammetry (SWV) with 0.2 mol L–1 KHSO4 background solution (pH ~ 0.8) (Ep = 0.25 V vs Ag,AgCl/KСl(sat)) differential pulse (DPV) 0.01 Na2 SO4+8×10–3 Н2SO4 background 0.9) 0.14 correspondingly were studied. voltammetric methods developed possibility to determine peroxomonosulfate in model solutions on studied was shown.

The electrochemical behaviour of potassium hydrogenperoxomonosulfate (KHSO5) in the presence sodium dodecylbenzenesulfonate (SDBS) has been studied using cathodic voltammetry at carbositall electrode as indicating potential range +1.0…–1.2 V (the reference Ag, AgCl/KСl(sat)) (Ep = +0.3 V). It experimentally proven that height KHSO5 reduction peak decreases and is shifted toward more electronegative values with increasing background electrolyte pH from 0.80 to 7.17. maximum (Ip) occurs a...

Aim. To develop a method for the quantitative determination of reduced glutathione in lyophilized powder preparation “Hepaval®” solution intravenous and intramuscular administration by effect inhibiting chemiluminescence luminol (H2L)–Н2О2–hemoglobin (Hb) system.Materials methods. The study object was substance injection, ampoules 4 mL No. 10 manufactured “Valartin pharma” (Italy). content determined using oxidation reaction with hydrogen peroxide presence Hb as catalyst. analysis performed...

The oxidative derivatization method using potassium hydrogenperoxomonosulfate for the indirect spectrophotometric determination of Fluphenazine hydrochloride is presented. Potassium introduced as a derivatizing agent hydrochloride, yielding sulfoxide. This reaction product was successfully used hydrochloride. UV spectroscopic detection sulfoxide proved to be more robust and sensitive method. elaborated allowed in concentration range 0.2-30 µg mL-1. molar absorptivity at 349 nm 5.6×103...