A5032128168- Blood groups and transfusion
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Erythrocyte Function and Pathophysiology
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Blood transfusion and management
- Telomeres, Telomerase, and Senescence
- Toxin Mechanisms and Immunotoxins
- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
- Blood disorders and treatments
- Pluripotent Stem Cells Research
- Viral Infections and Vectors
- Neonatal Health and Biochemistry
- Hemophilia Treatment and Research
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Transgenic Plants and Applications
- Viral Infectious Diseases and Gene Expression in Insects
Ministry of Health of the Russian Federation
2012-2023
National Research Center for Hematology Russian Academy of Medical Sciences
1994-2020
Endocrinology Research Center
2012-2013
Russian Academy of Sciences
1997-2009
Academy of Medical Sciences
2000-2009
Abstract Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy FcγRIIIa-mediated ADCC assays clinical trials. Structural variations oligosaccharide chains mAb-Ds are hypothesised to be responsible. Quantitative data on 12 Fc-glycosylation features 23 (12 clones, 5 produced from multiple cell lines) one blood donor-derived anti-D Ig were obtained by HPLC...
Adherence to proper indications for red blood cells (RBC) transfusion is essential because of its potential adverse effects and costs therapy. Aim these recommendations summarize typed RBC concentrates transfusions among different categories the patients. Methods. The methodological approaches are based on Russian expert council (leading specialists Federation) literature search randomized clinical trials evaluating storage duration, hemoglobin thresholds without language restrictions....
Background . Cryoprecipitate is made from fresh-frozen plasma (FFP) and contains fibrinogen, factor VIII, XIII, von Willebrand factor, fibronectin fibrinogen. Aim To provide information on the composition methods of production, storage, transportation clinical use cryoprecipitate. General findings Cyoprecipitate manufactured by slowly thawing FFP at 1–6°C. This precipitates out cryoproteins: After centrifugation, cryoproteins are resuspended in a reduced volume plasma. stored temperatures not...
Introduction. The identification of weak variants the A antigen, as well their differentiation, is necessary for proper selection erythrocyte-containing media blood transfusions. To this end, selective anti-A 1 reagents that react only with antigen are used in combination reacting equally and 2 antigens. Given expression varies within subgroups there no established standard procedures, interpretation obtained results presents difficulties. Aim. develop a strategy identifying using available...
Introduction. Cryosupernatant is blood component. the supernatant plasma removed during preparation of cryoprecipitate. Aim. To provide information on composition and methods production, storage, transportation clinical use Cryosupernatant. General fi ndings. In comparison with fresh frozen (FFP) cryoprecipitate, depleted in factor VIII, brinogen von Willebrand (VWF). defi cient high molecular weight multimers VWF, but contains VWF metalloproteinase. The concentrations V, antithrombin III,...
In this article, we commemorate the life and scientific journey of brilliant gerontologist-theorist Alexey Olovnikov (1936-2022). 1971, he published his famous "marginotomy" hypothesis, in which predicted replicative shortening telomeres its role as a counter cell divisions biological age an organism. This work put forth several remarkable assumptions, including existence telomerase, were confirmed two decades later. Despite this, moved further theoretical studies aging proposed series new...
In this article, we commemorate the life and scientific journey of brilliant gerontologist-theorist Alexey Olovnikov (1936-2022). 1971, he published his famous “marginotomy” hypothesis, in which predicted replicative shortening telomeres its role as a counter cell divisions biological age an organism. This work put forth several remarkable assumptions, including existence telomerase, were confirmed two decades later. Despite this, moved further theoretical studies aging proposed series new...