A5031713747- Antibiotic Resistance in Bacteria
- Wastewater Treatment and Nitrogen Removal
- Anaerobic Digestion and Biogas Production
- Microbial Fuel Cells and Bioremediation
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Antibiotic Use and Resistance
- Bacteriophages and microbial interactions
- Microbial Community Ecology and Physiology
- Nosocomial Infections in ICU
- Constructed Wetlands for Wastewater Treatment
- Biosensors and Analytical Detection
- Hybrid Renewable Energy Systems
- SARS-CoV-2 detection and testing
- Biofuel production and bioconversion
- Mycobacterium research and diagnosis
- Microbial Metabolic Engineering and Bioproduction
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- Water Treatment and Disinfection
- SARS-CoV-2 and COVID-19 Research
- Infection Control in Healthcare
- Microbial infections and disease research
University of Virginia Health System
2017-2024
University of Virginia
2018-2024
Museum of Heilongjiang Province
2021
University of Virginia Medical Center
2018
University of Utah
2010-2014
Indian Institute of Technology Kharagpur
2006-2010
Technical University of Denmark
2009
ABSTRACT There have been an increasing number of reports implicating Gammaproteobacteria as often carrying genes drug resistance from colonized sink traps to vulnerable hospitalized patients. However, the mechanism transmission wastewater P-trap patients remains poorly understood. Herein we report use a designated hand-washing lab gallery model dispersion green fluorescent protein (GFP)-expressing Escherichia coli surrounding environment. We found no GFP-expressing E. directly basin or...
Hydrolysate was tested as substrate for hydrogen production by extreme thermophilic mixed culture (70 degrees C) in both batch and continuously fed reactors. Hydrogen produced at hydrolysate concentrations up to 25% (v/v), while no concentration of 30% indicating that high inhibiting the fermentation process. In addition, lag phase strongly influenced concentration, prolonged from approximately 11 h below 20% (v/v) 38 (v/v). The maximum yield determined assays 318.4 +/- 5.2 mL-H(2)/g-sugars...
The increasing prevalence of nosocomial carbapenemase-producing Enterobacteriaceae is a concern. However, the role environment in multispecies outbreaks remains poorly understood. There recognition that hospital wastewater plumbing may play role. Covers were installed on all hoppers (a "toilet-like" waste disposal system) adult intensive care units (ICUs) university hospital; additionally surgical ICU, sink trap heating and vibration devices also installed. Patient acquisitions Klebsiella...
Wastewater-based monitoring for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the individual building level could be an efficient, passive means of early detection new cases in congregate living settings, but this approach has not been validated. Preliminary samples were collected from a hospital and local municipal wastewater treatment plant. Molecular diagnostic methods compared side by to assess feasibility, performance, sensitivity. Refined sample collection processing...
Among the possible environmental reservoirs in a patient care environment, sink drains are increasingly recognized as potential reservoir to hospitalized patients of multidrug-resistant health care-associated pathogens. With increasing antimicrobial resistance limiting therapeutic options for patients, better understanding how pathogens disseminate from is urgently needed. Once this knowledge gap has decreased, interventions can be engineered decrease or eliminate transmission hospital...
Several emerging pathogens have arisen as a result of selection pressures exerted by modern health care. Klebsiella quasipneumoniae was recently defined new species, yet its prevalence, niche, and propensity to acquire antimicrobial resistance genes are not fully described.
Antibiotic-resistant bacteria originating from hospitals are ultimately discharged to municipal wastewater treatment plants (WWTP), which may serve as important reservoirs for the spread of antibiotic resistant genes. This study traced and quantified presence a rare but clinically relevant antimicrobial resistance gene; Klebsiella pneumoniae carbapenamase (KPC)-and viable organisms (KPCO) carried this gene in hospital, non-hospital discharges, various compartments within WWTP, receiving...
A laboratory scale semi-batch fed anaerobic ammonia oxidation (ANAMMOX) reactor was operated in the lab under two different feeding operations. In first scenario, termed as phase I, seeded and with NO(2) -N added externally filtrate to ratio needed for successful ANAMMOX. second also initiated shortly after start-up of ANAMMOX accomplish partial nitrification (nitritation reactor) generate -N. II, operation switched mode which case partially nitrified effluent from nitritation reactor. both...
With multidrug-resistant (MDR)
Antimicrobial resistance has been recognized as a threat to human health. The role of hospital sinks acting reservoir for some the most concerning antibiotic resistant organisms, carbapenemase producing Enterobacterales (CPE) is evident but not well understood. Strategies prevent establishment, interventions eliminate these reservoirs and factors which drive persistence CPE are established. We use uniquely designed sink lab transplant colonized plumbing with an aim understand dynamics in...
Congregate living poses one of the highest risk situations for transmission respiratory viruses including SARS-CoV-2. University dormitories exemplify such high-risk settings. We demonstrate value using building-level SARS-CoV-2 wastewater surveillance as an early warning system to inform when prevalence testing all building occupants is warranted. Coordinated daily composite samples and clinical in was used prompt screening otherwise unrecognized infected occupants. overlay detection...
In a previous paper, the first ever application of lytic bacteriophage (virus)-mediated biocontrol biomass bulking in activated sludge process using Haliscomenobacter hydrossis as model filamentous bacterium was demonstrated. this work we extended to another predominant bacterium, Sphaerotilus natans, notoriously known cause wastewater treatment systems. Very similar study, one isolated from that could infect S. natans and lysis. Significant reduction volume index turbidity supernatant...
Hospital wastewater is an increasingly recognized reservoir for resistant Gram-negative organisms. Factors involved in establishment and persistence of Klebsiella pneumoniae carbapenemase-producing organisms (KPCOs) hospital plumbing are unclear. This study was conducted at a with endemic KPCOs linked to reservoirs robust patient perirectal screening silent KPCO carriage. Over 5 months, both rooms occupied not by KPCO-positive patients were sampled three sites within each room (sink drain,...