A5005323932- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Reproductive Biology and Fertility
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Sperm and Testicular Function
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Reproductive Health and Technologies
- Microbial Metabolic Engineering and Bioproduction
- Cancer, Lipids, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Enzyme Structure and Function
- Assisted Reproductive Technology and Twin Pregnancy
- Pancreatitis Pathology and Treatment
- Fatty Acid Research and Health
- Amino Acid Enzymes and Metabolism
- Liver physiology and pathology
- Polyamine Metabolism and Applications
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Biliary and Gastrointestinal Fistulas
- Metabolism and Genetic Disorders
Shinshu University
2014-2023
Azumi Hospital
2021-2022
Kurashiki Medical Center
2011-2022
Ōtani University
2012
Hiroshima University
2008-2010
Cornell University
2010
University of Córdoba
2010
Matsunami General Hospital
2004
Kyowa Kirin (Japan)
1993-2001
Osaka University
1986
Cholangiocarcinoma (CCC) is a strongly aggressive malignancy for which surgical resection the only potential curative therapy. Sorafenib, multikinase inhibitor of RAF/MEK/ERK pathway, molecular-targeted drug that approved hepatocellular carcinoma (HCC) but not CCC. The differences in signaling pathway characteristics under sorafenib treatment between HCC (HLF, Huh7, PLC/PRF/5) and CCC (RBE, YSCCC, Huh28) cell lines were therefore investigated using proliferation, western blotting, apoptosis...
Abstract Purpose Limited research has been published on the effect of piezo‐assisted intracytoplasmic sperm injection (P‐ICSI). We evaluated P‐ICSI laboratory, clinical, and neonatal outcomes. Methods This retrospective study was based data collected between April 2011 October 2016. Total 1348 mature oocytes from 145 patients were analyzed. Laboratory, outcomes those given conventional (C‐ICSI) administered examined. Results showed significantly more favorable results, with a survival rate...
The chemical structure of diamondlike carbon (DLC) has been clarified by means the quantitative analysis C 1s X-ray photoelectron spectra DLC films with different electrical resistivities prepared unbalanced magnetron sputtering (UBMS) method. observed showed asymmetric shapes and shifts peak positions depending on resistivity films. Every spectrum was decomposed into four components that were represented Doniach–Šunjić (DŠ) function convoluted a Gaussian function. structures corresponding...
Conventional freezing procedures are not appropriate for surgically retrieved spermatozoa from the epididymis or testis because of their low numbers. Techniques cryopreservation small numbers have been fully established. We tried to develop a method single spermatozoon using Cryotop, which has simple structure and is easy handle. Different parameters influencing procedure, types container, sources spermatozoa, cryoprotectants were evaluated. The sperm recovery rate after thawing was similar...
Abstract Purpose This study determined the effect of laser‐assisted hatching on clinical and neonatal outcomes single vitrified blastocyst transfer. Methods From June 2014 to March 2018, 289 matched pairs after propensity score matching were analyzed. During warming procedure, a small section zona pellucida area in empty perivitelline space was sliced off using multiple laser beams. The laser‐treated group non‐treatment control Results In group, significantly higher rates pregnancy (40.8% vs...
ABSTRACT The dapA gene, encoding dihydrodipicolinate synthase (DDPS) partially desensitized to inhibition by l -lysine, was cloned from an -threonine- and -lysine-coproducing mutant of the obligate methylotroph Methylobacillus glycogenes DHL122 complementation nutritional requirement Escherichia coli mutant. Introduction gene into AL119, which is parent -threonine producing mutant, elevated specific activity DDPS 20-fold -lysine production 2- 3-fold with concomitant reduction in test tube...
Journal Article Amino Acid Production from Methanol by Methylobacillus glycogenes Mutants: Isolation of L-Glutamic Hyper-producing Mutants M. Strains, and Derivation L-Threonine L-Lysine-producing Them Get access Hiroaki Motoyama, Motoyama Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3–6–6 Asahi-cho, Machida-shi, 194, Japan Search for other works this author on: Oxford Academic Google Scholar Hideharu Anazawa, Anazawa Ryoichi Katsumata, Katsumata Kazumi Araki, Araki Present...
The present study examined pregnancy-related changes in the level of lipoperoxides and antioxidative substances such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px) vitamin E maternal fetal serum, liver, lungs, placenta using Wistar rats. Pregnant rats fed a standard diet (control animals) showed an increase blood to 3 times greater than non-pregnant level. When were E-deficient diet, produced much amounts. Fetal also contained concentrations by use diet. However,...
Abstract Oxygen‐related surface functional groups on diamond‐like carbon (DLC) films were derivatized with fluorine‐ and nitrogen‐related by the gas‐phase chemical derivatization (GCD) method, analyzed quantitatively X‐ray photoelectron spectroscopy (XPS). It is desirable that a reaction unique to target group; however, it usually causes undesirable side reactions which affect other groups. This diversity of has complicated analysis. In this report, we have overcome problem applying...
Abstract Background Splenic vein stenosis and occlusion, which are known causes of left-sided portal hypertension, often occur secondary to trauma, pancreatitis, or invasion compression by pancreatic tumors. However, few reports have described idiopathic splenic stenosis. Case presentation A 70-year-old man was referred our hospital for examination isolated gastric varices. He had no history liver disease, abdominal trauma. Computed tomography revealed almost the entire length vein,...
Abstract Background Since cholangiocarcinoma has a poor prognosis, several epidermal growth factor receptor (EGFR)-targeted therapies with antibody or small molecule inhibitor treatment have been proposed. However, their effect remains limited. The present study sought to understand the molecular genetic characteristics of related EGFR, emphasis on its degradation and recycling. Methods We evaluated EGFR expression colocalization by immunoblotting immunofluorescence, cell surface...
Abstract Purpose Prolonged exposure to equilibration solutions may be detrimental an embryo's developmental potential, whereas a shorter affect the penetration of cryoprotectants into blastomeres. The purpose this study was evaluate effects different times on clinical and neonatal outcomes human blastocyst vitrification. Methods This is retrospective based data collected between November 2008 2015. A total 192 blastocysts (80 non‐expanded 112 expanded) obtained from 167 patients were...