A5101466904- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced Breast Cancer Therapies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Family and Patient Care in Intensive Care Units
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Gastrointestinal Bleeding Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Exercise and Physiological Responses
- Immunotherapy and Immune Responses
- Intensive Care Unit Cognitive Disorders
- Cancer survivorship and care
- Lymphatic System and Diseases
- Ubiquitin and proteasome pathways
- Healthcare Decision-Making and Restraints
- Gastric Cancer Management and Outcomes
Sichuan University
2022-2024
State Key Laboratory of Biotherapy
2022-2024
Qingdao University
2020-2022
Qingdao Municipal Hospital
2022
Although the MAPK pathway is aberrantly activated in triple-negative breast cancers (TNBCs), clinical outcome of MEK-targeted therapy still poor. Through a genome-wide CRISPR-Cas9 library screening, we find that inhibition PSMG2 sensitizes TNBC cells BT549 and MB468 to MEK inhibitor AZD6244. Mechanistically, knockdown impairs proteasome function, which turn activates autophagy-mediated PDPK1 degradation. The degradation significantly enhances AZD6244-induced tumor cell growth by interrupting...
Abstract Aims and objectives The study aims to explore describe nurses' behaviours towards physical restraint (PR) use in intensive care units (ICUs) identify key characteristics of these experiences. Background Patients within the ICU are always vulnerable, which requires a thoughtful deliberation when employing PR ethically laden situations. Considering that qualitative on ICUs is limited, deep understanding how nurses reason restrict patients necessary before developing minimizing...
Hepatocellular carcinoma (HCC) is one of the most lethal cancers, usually diagnosed at an advanced stage. Metabolic reprogramming plays a significant role in HCC progression, probably related to immune evasion, yet key gene unclear. In this study, six metabolism-related genes with prognostic implications were screened. Correlation analysis between and cell subtypes was conducted, prominent strongly associated immunosuppression, SLC16A3, identified. Overexpression SLC16A3 loss T-cell function...