Kieran J. Guinan

ORCID: 0000-0003-0887-0927
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About
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Research Areas
  • Plant Growth Enhancement Techniques
  • Immune Cell Function and Interaction
  • Reproductive System and Pregnancy
  • T-cell and B-cell Immunology
  • Plant Stress Responses and Tolerance
  • Composting and Vermicomposting Techniques
  • Marine and coastal plant biology
  • Aluminum toxicity and tolerance in plants and animals
  • Nuclear Structure and Function
  • Microtubule and mitosis dynamics
  • DNA Repair Mechanisms
  • Fatty Acid Research and Health
  • Layered Double Hydroxides Synthesis and Applications
  • biodegradable polymer synthesis and properties
  • Polymer composites and self-healing
  • Cancer-related gene regulation
  • Growth and nutrition in plants
  • Flowering Plant Growth and Cultivation
  • Microbial Metabolites in Food Biotechnology
  • Seaweed-derived Bioactive Compounds
  • Genetic Associations and Epidemiology
  • IL-33, ST2, and ILC Pathways
  • RNA modifications and cancer
  • Animal Nutrition and Physiology
  • Probiotics and Fermented Foods

BioAtlantis (Ireland)
2015-2023

Urology Foundation
2012

Trinity College Dublin
2007-2011

Abstract NK cells express both inhibitory and activatory receptors that allow them to recognize target through HLA class I Ag expression. KIR3DL1 is a receptor recognizes the HLA-Bw4 public epitope of HLA-B alleles. We demonstrate polymorphism within has functional consequences in terms cell recognition target. Inhibitory alleles differ their ability ligand, consistent hierarchy ligand reactivity can be defined. KIR3DS1, which segregates as an allele KIR3DL1, short cytoplasmic tail...

10.4049/jimmunol.178.1.235 article EN The Journal of Immunology 2007-01-01

Hepatitis C is a common infection with significant morbidity and mortality, only minority of patients successfully clear the infection. Identification factors that influence disease progression in HCV difficult owing to lack well-defined patient cohorts. However, recent evidence supports role for innate immune system virus clearance. In this study, we investigated genes their contribution unique cohort well-controlled HCV-infected patients. The Irish uniquely homogenous; were infected single...

10.1073/pnas.1016358108 article EN Proceedings of the National Academy of Sciences 2011-03-14

Abiotic stresses cause oxidative damage in plants. Here, we demonstrate that foliar application of an extract from the seaweed Ascophyllum nodosum, SuperFifty (SF), largely prevents paraquat (PQ)-induced stress Arabidopsis thaliana. While PQ-stressed plants develop necrotic lesions, pre-treated with SF (i.e., primed plants) were unaffected by PQ. Transcriptome analysis revealed induction reactive oxygen species (ROS) marker genes, genes involved ROS-induced programmed cell death, and...

10.3390/ijms21020474 article EN International Journal of Molecular Sciences 2020-01-11

Abiotic stresses, which at the molecular level leads to oxidative damage, are major determinants of crop yield loss worldwide. Therefore, considerable efforts directed towards developing strategies for their limitation and mitigation. Here superoxide-inducing agent paraquat (PQ) was used generate stress in model species Arabidopsis thaliana crops tomato pepper. Pre-treatment with biostimulant SuperFifty (SF) effectively universally suppressed PQ-induced leaf lesions, H2O2 build up, cell...

10.3390/metabo11010024 article EN cc-by Metabolites 2020-12-31

The use of probiotics, prebiotics and synbiotics in poultry diets beneficially stimulates the gut microbiome thus promoting health welfare animals. In this study, we analyzed 7 probiotics (Lactobacillus plantarum - B1 B4, Lactobacillus rhamnosus B3, Bifidobacterium lactis B2, Carnobacterium divergens B5, Propionibacterium thoenii B6, Clostridium butyricum B7) 12 prebiotics, differing chemical composition source origin (fungi, algae, animal, etc.). main goal our research was to select most...

10.3389/fmicb.2023.1242027 article EN cc-by Frontiers in Microbiology 2023-09-22
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