The failure of pancreatic islet β-cells is a major contributor to the etiology type 2 diabetes. β-Cell dysfunction and declining β-cell mass are two mechanisms that contribute this failure, although it unclear whether they molecularly linked. Here, we show cell cycle regulator, cyclin-dependent kinase (CDK2), couples primary progressive deterioration in Mice with pancreas-specific deletion Cdk2 glucose-intolerant, primarily due defects glucose-stimulated insulin secretion. Accompanying loss...

This study explores the internal standards for hearing tests and benefits of implementing international standard protocols, including International Organization Standardization (ISO) Electrotechnical Commission (IEC), discusses how ISO IEC provide a framework designing, calibrating, assessing test instruments methods, exchanging comparing data globally. improve accuracy, reliability, consistency results by applying standardized methods environments. Moreover, they promote harmonization...

To respond to disasters such as earthquakes, wildfires, and armed conflicts, humanitarian organizations require accurate timely data in the form of damage assessments, which indicate what buildings population centers have been most affected. Recent research combines machine learning with remote sensing automatically extract information from satellite imagery, reducing manual labor turn-around time. A major impediment using methods real disaster response scenarios is difficulty obtaining a...

이 연구에서는 중등 예비과학교사의 수업 계획의 특징과 이에 영향을 미친 요인을 조사하였다. 서울 소재 사범대학에 재학 중인 13명의 예비과학교사가 연구에 참여하였다. 예비교사들이 작성한 교수학습 지도안과 활동지 등의 자료, 계획 일지를 수집하였으며, 요소별로 예비교사들의 계획에 대한 심층적인 정보를 얻기 위해 반구조화된 면담을 실시하였다. 연구 결과, 대부분의 예비교사들은 차시 계획에만 초점을 맞추어 교육과정을 체계적으로 고려하지 않았다. 목표는 계획에서 부차적인 요소로 간주되었으며, 주로 인지적 측면에만 기술되었다. 전략을 구체화하는 것은 출발점이 되었는데, 자신의 중등학교에서의 학습 경험을 반성적으로 평가하는 과정을 통해 예비교사 교육과정에서 학습한 구성주의적 이론을 수용하여 활용하였다. 활동으로 실험 활동을 계획한 경우에는 교과서에 수록된 그대로 사용하는 경향이 높았으나, 외의 활동은 개인적 경험에 의존하여 계획하는 것으로 나타났다. 또한, 평가를 인식하지 못하여 이를...

Aim The purpose of the present study was to evaluate speech recognition ability and degree listening effort for older adults in noisy reverberating environments. Methods A total 80 participants (40 40 younger adults) participated a sentence test under 20 conditions with four levels background noise five reverberation time. In each condition, self‐reported using 5‐point Likert scale. Results groups showed that both error percentage task scale increased as time increased. task, group more...

국내 영아의 발성 및 조음발달 목록 개발Purpose: The purpose of this study was to develop Korean Infant Vocal and Articulatory Development (KIVAD) list set up a baseline for ultimately applying articulations vocalization infants' aural rehabilitation program.Methods: 24 normal hearing infants at 1-3 month age group, 28 4-5, 33 6-7, 34 8-9, 10-11, 35 12-13, 36 14-15, 23 16-17, 18-19, 37 20-21, 43 22-24 participated in study.We videotaped analyzed their 34,065 vocalizations articulations.The samples were...

Listening effort is defined as a listener's mental exertion required to understand speaker's auditory message, especially when distracting conditions are present. This review paper analyzed several subjective scaling tools used measure the listening in order suggest best tool for use with hearing-impaired listeners who have expend much even everyday life. We first explained importance of measuring and discussed various kinds measurements. then categorized 15 recently published articles...

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Pure-tone audiometry, using an audiometer, is the fundamental hearing test for diagnosing loss. The requirements of devices and detailed process calibrating related equipment are described in international standards. However, traceable calibration uncertainty evaluation processes not widely accepted or applied to qualification maintenance audiometric equipment. Here, we briefly review standard measurement systems introduce their procedures. each was investigated, its impact on results...

The purpose of this study is to examine the effects co-teaching in Practical Arts classes has on participation students inclusive elementary classrooms, as well attitude without disabilities toward accepting with disabilities. For purpose, participants were two and 40 from classes. was implemented one times a week for total 24 sessions during class time. This used pre- post-test control group design. After terminated, differences between dependent variables analyzed. results analysis...

Deep learning technologies have revolutionized image processing and analysis, introducing groundbreaking innovations that significantly improve the accuracy efficiency of object segmentation, especially in satellite imagery.The increasing availability high-resolution images has created a demand for advanced models capable handling complexities detection diverse environments.This study investigates potential Segment Anything Model Remote Sensing (SAMRS), deep framework specifically designed...

Many studies have reported no benefit of sound localization, but improved speech understanding in noise after treating patients with single-sided deafness (SSD). Furthermore, their performances provided a large individual difference. The present study aimed to measure the ability perception and gap detection for SSD better understand hearing nature.Nine different onset period deprivation 20 young adults normal simulated conductive loss as control groups conducted (SPIN) Gap-In-Noise (GIN)...

Multiple endocrine neoplasia (MEN) syndrome is typified by the occurrence of tumors in two or more hormonal tissues.Whereas genetics MEN relatively well understood, tumorigenic mechanisms for these cancers remain obscure.The Cdk4 R24C mouse model develops highly penetrant pituitary and pancreas adenomas, and, as such, this appropriate to gain insight into underlying MEN.Using model, here we provide evidence supporting an important role telomerase pathogenesis MEN.We observed increased...

Teleportation is a prominent locomotion technique in virtual reality that allows users to move across wider area without physical constraints. While various teleportation methods have been proposed previous studies, there lack of comparing their performance and determining which method suits specific environmental situations. This study measures compares the efficiency accuracy three targeting (hand controller, head-tracking, eye-tracking) during teleportation. A behavioral experiment...

Background and Objectives: This study aimed to investigate the occupational performance of Korean workers with without hearing loss analyze hearing-related difficulties in working environment.Subjects Methods: The Amsterdam checklist for work was used analyses environments were investigated. Out 129 total participants, 86 experienced severe profound 43 had normal ability. hearing-impaired recruited from two leading vocational centers normal-hearing their colleagues.Results: found take fewer...

With the various social services such as Facebook, Twitter and YouTube, many kind of bit data types are exponentially increasing. Therefore, people have difficulties to find sub-optimal service among overflow in Internet. In education area, new trend with ICT tools STEAM (Science, Technology, Engineering, Arts Mathematics) supportive computational thinking software is famous. this paper, we propose YouTube aware personalized recommender system for future education. It a technique...

이 연구에서는 2007 개정 교육과정에 의한 중학교 과학 교과서 27권의 삽화를 성역할 고정관념의 측면에서 분석하고, 그 결과를 7차 교과서와 비교하였다. 삽화의 유형을 분류한 후, 삽화에 등장하는 학생과 성인의 성별 등장 빈도, 활동 유형 및 행동 특성의 빈도를 분석하였다. 교육과정기에 비해 모든 분석 항목에서 성별에 따른 차이가 감소하였으나, 학생의 학습 활동과 학생 특성을 제외한 여전히 고정관념이 나타났다. 남학생의 빈도는 여학생보다 많았는데, 활동에서는 빈도가 균형을 이루고 있었으나 학습외 활동은 남학생을 중심으로 묘사되어 있었다. 경우에는 남성이 여성보다 많이 등장하였고, 가정 여성의 비율이, 가정외 남성의 비율이 우세하였다. 직업 활동에는 주로 성인은 대부분 적극적 보였고, 성인 모두 각 내에서 비교적 유사하였다. In this study, the illustrations of 27 middle school science textbooks developed...

Purpose: It is increasingly acknowledged that auditory brainstem response (ABR) elicited by speech can reflect the listener's perceptual cues of complex sound with replicability and reliability.This study sought to identify responses evoked Korean syllables characterize any relation between acoustic features their neurophysiological at level.Methods: Thirty young adults normal hearing who were native speakers participated in study.As stimuli, nine syllables, i.e., a combination plosives /p,...

While evaluating the speech recognition ability of older adults, present study aimed to analyze their error types in parts and find patterns under various conditions background noise level speed speech.Twenty adults with normal hearing for age (NHiA) 20 sensorineural loss (SNHL) participated. Their cognitive function was screened as within range (mini-mental state examination scores >25). The SNHL listeners were divided into high performers (SNHL-H; n=12) low (SNHL-L; n=8), based on...

The present study aimed to compare thresholds of direct bone-conduction (BC direct) with those behaviorally measured BC pure-tone audiometry (PTA) and objectively auditory brainstem response (ABR) confirm the clinical feasibility their relationships. Subjects and.Young adults normal hearing participated in determine from three measurements at four testing frequencies. In direct, vibrator a bone-anchored aid softband was placed on right mastoid each subject. both PTA ABR, B71 bone oscillator...

Objectives The aim of this paper was to determine if a correlation exists between video head impulse test (vHIT) and electronystagmography with caloric (ENG). More specifically, comparison covert overt value from vHIT cold warm stimulation ENG test. Methods Retrospective study our single institue the period January 2015 2017 enrolled 91 patients. Patients were divided into 3 groups by their diagnosis either vestibular neuritis (VN), Meniere disease, or sudden sensorineural loss vertigo...

As the technology advances and bone conduction implant (BCI) use increases, implantable hearing aids are regarded as a treatment method for single-sided deafness (SSD) their efficacy on SSD must be discussed. Therefore, we organized problems of types explained effectiveness in terms changes 1) speech recognition noisy environment, 2) sound localization, 3) subjective satisfaction assessed by questionnaire, 4) tinnitus. Although do not significantly improve localization ability SSD, they...