Irina Săplăcan

ORCID: 0000-0003-0899-3644
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About
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Research Areas
  • Sepsis Diagnosis and Treatment
  • Hemodynamic Monitoring and Therapy
  • Thermal Regulation in Medicine
  • COVID-19 Clinical Research Studies
  • Treatment of Major Depression
  • Takotsubo Cardiomyopathy and Associated Phenomena
  • Renal function and acid-base balance
  • Hip and Femur Fractures
  • Intraperitoneal and Appendiceal Malignancies
  • Hernia repair and management
  • Electrolyte and hormonal disorders
  • Inflammatory Biomarkers in Disease Prognosis
  • Lymphatic System and Diseases
  • Long-Term Effects of COVID-19
  • Appendicitis Diagnosis and Management
  • COVID-19 and healthcare impacts
  • Biomarkers in Disease Mechanisms
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Immune Response and Inflammation
  • Electroconvulsive Therapy Studies
  • Anesthesia and Sedative Agents
  • Epilepsy research and treatment
  • Cardiac, Anesthesia and Surgical Outcomes
  • Neonatal Respiratory Health Research
  • Neurological disorders and treatments

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2021-2025

Spitalul Clinic Judetean de Urgenta Târgu Mureş
2021-2022

The present study was a prospective observational single center study, enrolling 102 patients with sepsis, admitted in the Intensive Care Unit of County Emergency Clinical Hospital Târgu Mureș (Mureș, Romania). main goal to compare changes following parameters on day 1 compared 5, sepsis septic shock, as well survivors non‑survivors: Cell blood count parameters, neutrophil‑lymphocyte ratio, platelet‑lymphocyte ratio and systemic inflammation index, C reactive protein (CRP), ferritin,...

10.3892/etm.2024.12489 article EN Experimental and Therapeutic Medicine 2024-03-15

Introduction: The management of sedation during percutaneous endoscopic gastrojejunostomy (PEG-J) placement in patients with advanced Parkinson’s disease (PD) is challenging due to the complex interactions between PD treatment, anesthetic agents, and disease’s motor non-motor symptoms. This study evaluates effectiveness safety a target-controlled infusion (TCI) propofol protocol context PEG-J patients. Materials Methods: prospective included 169 diagnosed (Hoehn Yahr stages 4 5) who...

10.3390/life15030492 article EN cc-by Life 2025-03-18

The increased production of carbon monoxide (CO) in sepsis has been proven, but the blood level variations carboxyhemoglobin (COHb) as a potential evolutionary parameter COVID-19 and sepsis/septic shock have yet to be determined. This study aims evaluate serum variation COHb critically ill patients bacterial sepsis.A prospective observational was conducted on two groups patients: group (n = 52) 52). We followed paraclinical parameters Day 1 (D1) 5 (D5) sepsis/ICU admission for patients.D1...

10.3390/microorganisms10020305 article EN cc-by Microorganisms 2022-01-27

Background and Objectives: Numerous scoring systems have been introduced into modern medicine. None of the assessed both anesthetic surgical risk patient, predict morbidity, mortality, or need for postoperative intensive care unit admission. The aim this study was to compare scores currently used, a better evaluation perioperative risks, mortality. Material Methods: This is pilot, prospective, observational study. We enrolled 50 patients scheduled elective surgery. Anesthetic surgery using...

10.3390/medicina57101132 article EN cc-by Medicina 2021-10-19

(1) Background: Since the onset of COVID-19 pandemic, it has been recognized that a considerable proportion critically ill patients may die this disease. The current study aims to assess overall 1-year outcomes within UMFST Unit, providing valuable insights into efficacy specialized care facilities in managing severe cases COVID-19. (2) Methods: This is retrospective monocentric observational including 294 confirmed have SARS-CoV-2 infection. Demographic data and clinical paraclinical...

10.3390/life14101232 article EN cc-by Life 2024-09-26

Proper management of sepsis poses a challenge even today, with early diagnosis and targeted treatment being the most important steps. Easy, cost-effective bedside tools are needed in order to pinpoint towards outcome or septic shock.This study aims find correlation between Sequential Organ Failure Assessment (SOFA), Acute Physiology Chronic Health Evaluation II (APACHE II) Simplified Score (SAPS severity scores, Neutrophil-Lymphocytes Ratio (NLR) carboxyhaemoglobin (COHb) levels shock...

10.2478/jccm-2023-0031 article EN cc-by ˜The œJournal of Critical Care Medicine 2023-10-01

Serotonin syndrome (SS), also known as serotonin toxicity, is a life-threatening condition induced by certain drugs that affect metabolism. We report case of SS, combination three encountered in patient with previously suspected allergy to metoclopramide and pitofenone discovered an "anaesthetic incident". In the immediate postoperative period, following administration antiemetic analgesic treatment, presented generalized myoclonus intense abdominal pain. The diagnosis SS was established...

10.47391/jpma.3806 article EN cc-by Journal of the Pakistan Medical Association 2022-04-05

Abstract Introduction : Acute abdominal pain persists in defying modern diagnostic procedures. Inflammatory response variables urine and blood tests can help rule out other disorders support a clinical diagnosis of acute appendicitis (AA), but there is no specific test that diagnose AA. In order to address this, our study sought establish the value (NLR) as prognostic severity predictor patients with Material method We conducted an observational retrospective 356 who had undergone surgery...

10.2478/rrlm-2022-0002 article EN cc-by-nc-nd Revista română de medicină de laborator 2022-01-01

Abstract Background : Sepsis is the leading cause of morbidity and mortality in intensive care units. This study explored possible role vascular endothelial growth factor-C (VEGF-C) podoplanin (PDPN) sepsis. Methods 22 Wistar rats were divided into three groups: two experimental (Group A B, n=8/8) a control C, n=6). was induced with intraperitoneal injection ESBL (extended-spectrum beta-lactamases)-producing E-coli live bacteria for group lipopolysaccharide B. Sterile saline solution...

10.2478/rrlm-2021-0030 article EN cc-by-nc-nd Revista română de medicină de laborator 2021-10-01
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