A5088604504- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Regulation of Appetite and Obesity
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- BRCA gene mutations in cancer
- Diabetes Management and Research
- Biochemical Analysis and Sensing Techniques
- Pluripotent Stem Cells Research
- Salivary Gland Tumors Diagnosis and Treatment
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Balance, Gait, and Falls Prevention
- Metastasis and carcinoma case studies
- Ion Channels and Receptors
Northwestern University
2020-2024
Korea Advanced Institute of Science and Technology
2002-2024
John H. Stroger, Jr. Hospital of Cook County
2024
Northwestern Memorial Hospital
2023
The University of Texas at Austin
2023
Rütgers (Germany)
2023
Rutgers, The State University of New Jersey
2023
Rutgers Sexual and Reproductive Health and Rights
2023
Florida State University
2022
Seoul Metropolitan Government
2016-2021
Abstract Insulin secretion is elaborately modulated in pancreatic ß cells within islets of three-dimensional (3D) structures. Using human pluripotent stem (hPSCs) to develop islet-like structures with insulin-producing for the treatment diabetes challenging. Here, we report that clusters derived from hESCs are functionally capable glucose-responsive insulin as well therapeutic effects. Pancreatic hormone-expressing endocrine (ECs) were differentiated using a step-wise protocol. The...
Serotonin (5-HT) neurons, the major components of raphe nuclei, arise from ventral hindbrain progenitors. Based on anatomical location and axonal projection, 5-HT neurons are coarsely divided into rostral caudal groups. Here, we propose a novel strategy to generate human pluripotent stem cells (hPSCs), which involves formation ventral-type neural progenitor stimulation development. A caudalizing agent, retinoid acid, was used direct cell fate. Approximately 30%–40% hPSCs successfully...
Treating advanced thyroid cancer presents challenges due to its resistance various treatment modalities, thereby limiting therapeutic options. To our knowledge, this study is the first report efficacy of temsirolimus in conjunction with dual immunotherapy nivolumab/ipilimumab treat heavily treated PDTC. A 50-year-old female initially presented a rapidly enlarging mass on her right neck. Subsequent diagnosis revealed poorly differentiated carcinoma, leading total thyroidectomy followed by...
Anti-reflux surgery (ARS) is an efficient treatment option for gastroesophageal reflux disease (GERD). Despite growing evidence of the efficacy and safety ARS, medications including proton pump inhibitors (PPIs) remain most commonly administered treatments GERD. Meanwhile, ARS can be effective patients who need continuously or those are refractory to PPI treatment, if proper candidates selected. However, in practice, often regarded as a last resort unresponsive PPIs. Accumulating ARS-related...
The ventromedial hypothalamic nucleus (VMH) regulates energy balance and glucose homeostasis. Leptin insulin exert metabolic effects via their cognate receptors expressed by the steroidogenic factor 1 (SF1) neurons within VMH. However, detailed cellular mechanisms involved in regulation of these leptin remain to be identified.We utilized genetically-modified mouse models performed patch-clamp electrophysiology experiments resolve this issue.We identified distinct populations leptin-activated...
In vitro culture systems for primary neurons have served as useful tools neuroscience research. However, conventional in methods are still plagued by challenging problems with respect to applications neurodegenerative disease models or neuron-based biosensors and neural chips, which commonly require long-term of cells. These impediments highlight the necessity developing a platform capable sustaining activity over months. Here, we designed series polymeric bilayers composed poly(glycidyl...
To characterize Staphylococcus aureus faecal isolates from people suspected to be infected with food poisoning by using antimicrobial susceptibility testing and molecular techniques.A total of 340 Staph. 6226 were identified characterized biochemical methods, PCR. Samples obtained January 2006 December 2008 the National Notifiable Diseases Surveillance System at Research Institute Public Health Environment in Seoul Metropolitan, Korea. All strains carried least one eight staphylococcal...
Jogaejeot, seasoned Venerupis philippinarum, is a traditional Korean fermented food, and hepatitis A virus (HAV) can be transmitted through contaminated especially bivalve shellfish, causing acute gastroenteritis worldwide. Here, we carried out phylogenetic analysis to identify characterize HAV strains in jogaejeot samples associated with (HA) outbreaks Seoul, South Korea, 2019. The were identified using blast molecular of the amplified VP1-P2B genome region. five shared at least 99%...
Triptans are a class of commonly prescribed antimigraine drugs. Here, we report previously unrecognized role for them to suppress appetite in mice. In particular, frovatriptan treatment reduces food intake and body weight diet-induced obese Moreover, the anorectic effect depends on serotonin (5-HT) 1B receptor (Htr1b). By ablating Htr1b four different brain regions, demonstrate that engages spatiotemporally segregated neural pathways regulate postnatal growth intake. AgRP neurons arcuate...
Abstract Introduction: Dual checkpoint inhibitor therapy with nivolumab and ipilimumab has been FDA-approved for a number of different cancers including melanoma, recurrent NSCLC, hepatocellular carcinoma. However, their role in the treatment ACC other salivary gland carcinomas is not well established. Methods: We performed Simon’s two-stage prospective single-institution phase II clinical trial (240 mg intravenously every 2 weeks 16 weeks, then 480 4 weeks) (1 mg/kg 6 weeks), both which...
It is well known that the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase appetite and decrease thermogenesis. Previous studies demonstrated optogenetic and/or chemogenetic manipulations of NPY/AgRP neuronal activity alter food intake energy expenditure (EE). However, little about intrinsic molecules regulating excitability to affect long-term metabolic function. Here, we found G protein-gated inwardly rectifying K+ (GIRK) channels are key stabilize neuron-selective...
Abstract Objective Dual checkpoint inhibitor therapy with nivolumab and ipilimumab has been FDA-approved for a number of cancer sites. However, their role in the treatment ACC other salivary gland carcinomas is not well established. Methods analysis We performed Simon’s two-stage prospective single-institution phase II clinical trial ipilimumab. Two cohorts were analyzed: patients metastatic/recurrent cancers. The primary endpoint was median progression-free survival (PFS); secondary...
Secretion of insulin from the pancreas is pulsatile, driven by intrinsic oscillations within individual islets Langerhans. The secretions are coordinated among many distributed throughout producing a synchronized rhythm in vivo that essential for maintaining normal glucose levels. One hypothesized mechanism coordination islet activity negative feedback, whereby sequestration response to elevated leads reduction blood level sensed population. This global signal then coordinates islets. In...
3069 Background: Globally, cancer results in 10.08 million deaths per year. A single blood-based screening tool that detects multiple types could significantly reduce burden. We systematically reviewed and statistically examined both the accuracy applicability of MCED tests to strategize their utilization improving detection. Methods: Original articles were searched from PubMed, Cochrane, Embase for analyzing asymptomatic human subjects. excluded studies with small sample sizes (n<30),...
Melanocortin-4 receptors (MC4Rs) expressed by the central nervous system are essential regulators of energy homeostasis, and Mc4r mutation is most common cause human monogenic obesity. Notably, patients with obesity carrying mutations protected against obesity-induced hypertension, MC4R agonists elevate blood pressure (BP). Although increased sympathetic tone MC4Rs suggested to underlie this phenotype, detailed mechanisms remain unclear. Here, we investigate how regulate preganglionic...
Objective Our goal was to assess the effect of dynamic CT during arterial dominant phase with uniphasic injection intravenous contrast material (5 ml/s) in detection and characterization hepatocellular carcinomas (HCCs). Materials Methods Three-phase incremental performed 66 patients 84 HCCs diagnosed by pathologic findings, characteristic angiographic clinical manifestations. One hundred fifty milliliters nonionic medium administered intravenously using a power injector at flow rate 5 ml/s...
Homozygosity at HLA-I locus has been reported to be an unfavorable predictive biomarker of second-line or beyond immunotherapy in patients with different types cancer. The linkage between zygosity and survival NSCLC treated first-line without chemotherapy not reported.Next generation sequencing HLA genotyping was performed on advanced immune checkpoint inhibitors as (N = 29). Progression free compared homozygous (defined homozygosity least one A, B, C) heterozygous patients. Kaplan-Meier...
Abstract Introduction Immune checkpoint inhibitors (ICIs) may be associated with hyperprogressive disease (HPD). However, there is currently no standardized definition of HPD, its risk factors and clinical implications remaining unclear. We investigated HPD in lung cancer patients undergoing immunotherapy, aiming to redefine identify factors, assess impact on survival. Methods Clinical radiologic data from 121 non-small cell (NSCLC) 136 immunotherapy cases were reviewed retrospectively....
Abstract Background: Radiomics models utilizing artificial intelligence are being explored as a potential biomarker in the field of oncology. analysis requires segmentations radiographic imaging. However, manual segmentation is labor-intensive process that time consuming, and acts major rate-limiting step. Thus development automated tools presents an opportunity for innovation regards to efficiency precision. Our study aims explore feasibility autosegmentation comparison with segmentation....
Abstract Background: With the increasing use of immunotherapy in advanced non-small cell lung cancer (NSCLC), managing adverse events, particularly checkpoint inhibitor-associated pneumonitis (CIP), poses a significant challenge. CIP often necessitates discontinuation immunotherapy, even cases tumor response. Currently there are no effective models predicting CIP. This study leverages artificial intelligence (AI) algorithms and harmonization to analyze radiomic features from chest CT scans,...