A5007470118- Pharmacogenetics and Drug Metabolism
- Pesticide Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Hormonal and reproductive studies
- Cholinesterase and Neurodegenerative Diseases
- Environmental Toxicology and Ecotoxicology
- Estrogen and related hormone effects
- Sexual Differentiation and Disorders
- Eicosanoids and Hypertension Pharmacology
- Pesticide and Herbicide Environmental Studies
- Insect and Pesticide Research
- Genomics, phytochemicals, and oxidative stress
- Viral Infectious Diseases and Gene Expression in Insects
- Drug Transport and Resistance Mechanisms
- Prostate Cancer Treatment and Research
- Heavy Metal Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Metabolism and Genetic Disorders
- Aluminum toxicity and tolerance in plants and animals
- Protein purification and stability
- Biochemical and Molecular Research
- Potassium and Related Disorders
- Glutathione Transferases and Polymorphisms
- Retinoids in leukemia and cellular processes
Instituto Politécnico Nacional
2015-2024
Center for Research and Advanced Studies of the National Polytechnic Institute
2015-2024
Environmental Protection Agency
2004-2011
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2009
Tokai University
2009
American Gastroenterological Association
2009
University of California Davis Medical Center
2009
Research Triangle Park Foundation
2004
Dichlorodiphenyltrichloroethane (DDT) is a well-known inducer of microsomal monooxygenase systems in rodent liver. However, little information available on its effects the sex-dependent regulation CYPs preferentially affected. Therefore, our objective was to evaluate DDT sexual expression pattern some hepatic P-450 isozymes. Single doses technical (0, 0.1, 1, 5, 10, or 100 mg/kg body wt) were administered by gavage Wistar rats. The 1A1, 2B1/2B2, 2C11, 2E1, 3A1, and 3A2, assessed 24 h later...
Caffeic acid phenethyl ester (CAPE), a natural component of propolis, shows anticarcinogenic properties in the modified resistant hepatocyte model when administered before initiation or promotion hepatocarcinogenesis process; however, information about mechanism underlying this chemoprotection is limited. The aim work was to characterize effect CAPE on cytochrome P450 (CYP), which involved diethylnitrosamine (DEN) metabolism during stage chemical hepatocarcinogenesis. Male Fischer-344 rats...
CYP3A4, the predominant cytochrome P450 (P450) expressed in human liver and intestine, contributes to metabolism of approximately half drugs clinical use today. CYP3A4 catalyzes 6β-hydroxylation a number steroid hormones is involved bioactivation environmental procarcinogens. The expression affected by several stimuli, including factors such as insecticides pesticides. <i>o,p</i>′-1,1,1,-trichloro-2,2-bis (<i>p</i>-chlorophenyl)ethane (DDT) isomer DDT comprises 20% technical grade DDT, which...
Abstract Temephos (Tem) is an organophosphorus pesticide widely used to kill and prevent the growth of main vectors for transmission dengue, zika, chikungunya viruses. In chlorinated water, Tem oxidized its dioxon-sulfoxide (Tem-dox-SO), dioxon-sulfone (Tem-dox-SO 2 ), sulfoxide (Tem-SO) derivatives; however, these compounds are not commercially available be as standards in toxicological studies. present study, we synthesized characterized Tem-oxidation products compound...
Vinclozolin (V) is a fungicide with antiandrogenic properties. To determine the pharmacokinetics and dosimetry of V, adult male rats were administered an oral dose V (100 mg/kg) in corn oil sacrificed over time after dosing. its metabolites analyzed serum tissues by high performance liquid chromatography/diode array detector/mass spectrometer. 2-[[(3,5-dichlorophenyl)-carbamoyl]oxy]-2-methyl-3-butenoic acid (M1), 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide (M2), five other detected...
Studies of cancer chemoprevention with caffeic acid phenethyl ester (CAPE) in the resistant hepatocyte model hepatocarcinogenesis have shown participation CYP drug metabolizing enzymes. To prevent neoplastic and preneoplasic lesions, we must specifically identify which activities are modified mechanism action CAPE. Male Fischer-344 rats were pretreated CAPE twelve hours before administration diethylnitrosamine (DEN) sacrificed after hours, twenty-four days, months DEN. Other treated...
Objective. To evaluate if variants in the genes CYP1A1 (T3801C and A4889G), CYP1B1 (G119T), GSTM1 (indel) GSTT1 are associated with breast cancer (BC) among Mexican women. Materials methods. 952 incident cases histologically confirmed BC were matched by age(± 5 years) zone of residence 998 healthy population controls. Genetic CYP1A1, CYP1B1, GSTT1were genotyped allelic discrimination multiplex PCR. In a subsample women, 105 markers for ancestry determined. Results. An increased risk,...
The degradation pathway of temephos pesticide was elucidated using efficient photocatalytic ZnO nanowire and flower-like films. monitoring the subproducts is crucial as they are even more toxic than original pesticide.
AIM:To study the effect of celecoxib (CXB) on diethylnitrosamine activation through regulation cytochrome P450 in a hepatocarcinogenesis model. METHODS:Six-week-old male Sprague-Dawley rats were randomly divided into five groups, nontreated group (NT), diethylnitrosamine-treated (DEN), DEN+CXB-treated (DEN+CXB), and CXB 8 d-treated 32 groups.The effects enzymatic activities CYP1A1, 2A, 2B1/2, 2E1 assessed hepatic microsomes 24 h after DEN administration.Changes CYP1A1 CYP2B1/2 protein...
Abstract Infection with high‐risk human papillomavirus (HR‐HPV) is the main cause of cervical cancer (CC), but viral infection alone does not guarantee development this malignancy. Indeed, deficiencies dietary micronutrients could favor in individuals that harbor HR‐HPV infections. The status retinoid levels, natural and synthetic derivatives vitamin A, important maintaining cellular differentiation epithelium. Moreover, many studies show a link between deficient intake retinoids or...
The aim of this paper is to report on the presence chemical interferences in quantitation methylated arsenic species human urine when using a method based selective volatile arsine generation, chromatographic separation, and hydride generation atomic absorption spectrometry (HGAAS) detection. An abnormal profile characterized by absence peak corresponding dimethylarsinic acid (DMA) was observed from some individuals exposed via drinking water living rural communities northwestern Argentina....
Epidemiological studies related to androgens and prostate cancer (PC) have focused on serum determination of testosterone, androstenedione (A4), DHEA, with inconsistent results. Herein, we hypothesized that differences in androgen biosynthetic metabolic pathways, rather than specific concentrations, are associated prostatic carcinogenesis. Therefore, spot urine samples from 111 incident PC cases Gleason score at diagnosis 227 healthy population controls, were analyzed. Urinary concentrations...
The interplay between pubertal events patterns (PEP) and prostate cancer (PCa) remains poorly understood. Therefore, we investigated the association of PEP with odds PCa, PCa histological differentiation in men residents Mexico city.In this case-control study, analyzed information 371 incident cases 775 controls matched on age (±5 years). High-grade was classified Gleason score at diagnosis as ≥8. With related to beard growth, maximum height attainment, acne severity, k-medoids algorithm...