A5043172952- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Bone and Joint Diseases
- MRI in cancer diagnosis
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Breast Lesions and Carcinomas
- Moyamoya disease diagnosis and treatment
- Vascular Malformations Diagnosis and Treatment
- Craniofacial Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Plasma Diagnostics and Applications
- Hedgehog Signaling Pathway Studies
- Cancer-related gene regulation
- Cleft Lip and Palate Research
- Combustion and Detonation Processes
- Sarcoma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Plasma Applications and Diagnostics
- Bone health and osteoporosis research
- Mycobacterium research and diagnosis
- RNA Research and Splicing
- Nutrition and Health in Aging
Guangdong Province Women and Children Hospital
2020-2024
Xian Yang Central Hospital
2017-2022
Tsinghua University
2013
Abstract Long non‐coding RNA (lncRNA) plays important roles in tumour progression. Accumulating studies demonstrated that lncRNA colon cancer‐associated transcript 2 (CCAT2) acted as an oncogene many tumours. However, the role of CCAT2 development osteosarcoma has not been elucidated. In our study, we indicated expression was up‐regulated tissues and cell lines (SOSP‐9607, MG‐63, U2OS SAOS‐2). addition, cases with higher had a poorer disease‐free survival shorter overall time compared to...
Long noncoding RNA (lncRNA) Linc00511 is a novel lncRNA, and it was reported to play important roles in the progression carcinogenesis of several tumors. However, expression biological osteosarcoma were still unknown. In this research, we showed that upregulated samples cell lines. Ectopic promoted growth, colony formation, migration. Moreover, overexpression enhanced epithelial-mesenchymal transition cell. addition, elevated suppressed microRNA-765 (miR-765) apurinic/apyrimidinic...
Osteosarcoma is the most common type of malignant bone tumor, often affecting adolescents and children. MicroRNAs (miRNAs) are a group small, non-protein coding, endogenous RNAs that play critical roles in osteosarcoma tumorigenesis. In our study, we demonstrated miR-448 expression was downregulated tissues cell lines. Overexpression suppressed proliferation, colony formation migration. Moreover, found EPHA7 direct target gene cells. We further level upregulated tissues. Interestingly,...
Studies have confirmed that antioxidants contribute to a lower risk of osteoporosis, which is an independent factor for femoral neck fracture (FNF). However, the associations between blood antioxidant levels and strength remain unclear.Our aim was test hypothesis are positively associated with composite indices bone in neck, integrate bending index (BSI), compressive (CSI), impact (ISI), population middle-aged elderly individuals.This cross-sectional study utilized data from Midlife United...
Long noncoding RNAs (lncRNAs) have been shown to be involved in the development of osteoarthritis. However, expression, function, and mechanism DLEU1 OA remain largely unclear. The present reference demonstrates that is overexpressed specimens compared control cartilages. Inflammatory cytokines IL-1β, TNF-α, IL-6 induce expression chondrocytes. Ectopic induces chondrocyte proliferation, degradation ECM, inflammation mediators such as IL-6, IL-8, TNF-α secretion. Moreover, we demonstrated...
In this paper, the visual features of microwave ignition process were investigated. To realize under high pressure, a 2.45 GHz cylinder resonator was designed. The electric field in and quality factor theoretically calculated. A needle-like coupling antenna introduced to further enhance maximum ensure reliability discharge. We ignited stoichiometric methane-air mixture at 10 bars by 2 ms, 1 kW, pulse. photography images pressure history obtained analyzed. These results compared with spark...
Abstract Background Non-mass enhancement (NME) is a diagnostic dilemma and highly reliant on the experience of radiologists. Texture analysis (TA) could serve as an objective method to quantify lesion characteristics. However, it remains unclear what role TA plays in predictive model based routine MRI The purpose this study was explore value distinguishing between benign malignant NME premenopausal women. Methods Women whom histologically proven (n = 147) were enrolled (benign: 58;...
Accumulating evidence shows that circRNAs play critical roles in the development of human tumors. We observed circ_0000527 was overexpressed osteosarcoma cells (SAOS-2, HOS, MG-63 and U2OS) compared hFOB1.19 cells. demonstrated level higher specimens than non-tumor specimens. The ectopic expression shown to induce cell growth, cycle progression secretion inflammatory mediators, including IL-1β, IL-6, IL-8 TNF-α. sponges miR-646 ARL2 is a target gene miR-646. MiR-646 decreased Overexpression...
Long non-coding RNAs (LncRNAs) play vital roles in the progression and development of tumors.However, functional role ROR1-AS1 osteosarcoma has not been investigated.We found that was upregulated tissues compared to non-tumor samples.Elevated expression promoted cyclin D1, PCNA ki-67 increased cell cycle growth MG-63 cell.Moreover, overexpression induced migration cell, promoting N-cadherin vimentin inhibiting E-cadherin expression.Dual-luciferase assay proved served as one sponge for...
Objective Auriculocondylar syndrome (ARCND) is a set of rare craniofacial malformations characterized by variable micrognathia, ear malformations, and mandibular condyle hypoplasia, other accompanying features with phenotypic complexity. ARCND2 caused pathogenic variants in the PLCB4 gene very disease less than 50 patients reported only 36 different recorded HGMD. This study aims to enrich patient resources, clinical data mutational spectrum ARCND2. Design Case series study. Setting...
Abstract Background: Non-mass enhancement (NME) is a diagnostic dilemma. Texture analysis (TA) could serve as an objective method to quantify tumor characteristics and growth patterns. However, there are few reports about TA use in NME diagnosis. To our knowledge, diagnosis based on the combination of features noted routine MRI has not been reported.. The purpose this study was explore value distinguishing between benign malignant premenopausal women. Methods: Women whom histologically...