A5103160219- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- Gallbladder and Bile Duct Disorders
- RNA modifications and cancer
- Advanced Proteomics Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Urinary Tract Infections Management
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- Biofuel production and bioconversion
- Polysaccharides and Plant Cell Walls
- Peroxisome Proliferator-Activated Receptors
- TGF-β signaling in diseases
- Berberine and alkaloids research
- Hippo pathway signaling and YAP/TAZ
- Curcumin's Biomedical Applications
Xian Yang Central Hospital
2017-2024
Nanfang Hospital
2021-2023
Southern Medical University
2021-2023
Sun Yat-sen University
2023
First Affiliated Hospital of Guangzhou Medical University
2019-2022
Guangzhou Medical University
2019-2022
Guangzhou Institute of Dermatology
2020-2021
307th Hospital of Chinese People’s Liberation Army
2019
82th Hospital of Pla
2017
Qilu University of Technology
2014
Diabetes mellitus is closely correlated with disc degeneration. Nucleus pulposus (NP) cell apoptosis and senescence are typical cellular features within the degenerative disc. Resveratrol a newly identified phytoalexin that has protective effects on cartilaginous tissue.
Background TP53 gene mutation is one of the most common mutations in human bladder cancer (BC) and has been implicated progression prognosis BC. Methods RNA sequencing data different populations platforms were downloaded from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) database to determine validate a TP53-associated immune prognostic signature (TIPS) based on differentially expressed immune-related genes (DEIGs) between muscle-invasive (MIBC) patients with without...
Abstract Long non‐coding RNA (lncRNA) plays important roles in tumour progression. Accumulating studies demonstrated that lncRNA colon cancer‐associated transcript 2 (CCAT2) acted as an oncogene many tumours. However, the role of CCAT2 development osteosarcoma has not been elucidated. In our study, we indicated expression was up‐regulated tissues and cell lines (SOSP‐9607, MG‐63, U2OS SAOS‐2). addition, cases with higher had a poorer disease‐free survival shorter overall time compared to...
Colorectal cancer (CRC) remains a challenging and deadly disease with high tumor microenvironment (TME) heterogeneity. Using an integrative multi-omics analysis artificial intelligence-enabled spatial of whole-slide images, we performed comprehensive characterization TME in colorectal (CCCRC). CRC samples were classified into four CCCRC subtypes distinct features, namely, C1 as the proliferative subtype low immunogenicity; C2 immunosuppressed terminally exhausted immune characteristics; C3...
Long noncoding RNA (lncRNA) Linc00511 is a novel lncRNA, and it was reported to play important roles in the progression carcinogenesis of several tumors. However, expression biological osteosarcoma were still unknown. In this research, we showed that upregulated samples cell lines. Ectopic promoted growth, colony formation, migration. Moreover, overexpression enhanced epithelial-mesenchymal transition cell. addition, elevated suppressed microRNA-765 (miR-765) apurinic/apyrimidinic...
Bladder cancer (BC) is a common urinary tract system tumor with high recurrence rate and different populations show distinct response to immunotherapy. Novel biomarkers that can accurately predict prognosis therapeutic responses are urgently needed. Here, we aim identify novel prognostic immune-related gene signature of BC through comprehensive bioinformatics analysis.The robust rank aggregation was conducted integrate differently expressed genes (DEGs) in datasets the Cancer Genome Atlas...
Osteosarcoma is the most common type of malignant bone tumor, often affecting adolescents and children. MicroRNAs (miRNAs) are a group small, non-protein coding, endogenous RNAs that play critical roles in osteosarcoma tumorigenesis. In our study, we demonstrated miR-448 expression was downregulated tissues cell lines. Overexpression suppressed proliferation, colony formation migration. Moreover, found EPHA7 direct target gene cells. We further level upregulated tissues. Interestingly,...
Coptis chinensis Franch (CCF) is extensively used in the treatment of inflammatory-related diseases. Accumulating studies have previously demonstrated anti-inflammatory properties CCF, yet data on its exact targets against urinary tract infections (UTIs) remain largely unknown. Therefore, present study decodes potential action CCF UTIs by network pharmacology combined with experiment evaluations. Based analysis, current yielded six core ingredients: quercetin, palmatine (R)-canadine,...
The time and speed of biochemical recurrence (BCR) prostate cancer (PCa) after radical prostatectomy (RP) is highly variable. Stratification methods based on TNM staging Gleason score (GS) do not allow the identification patients at risk BCR following RP. Therefore, aim present study was to identify molecular signatures that can predict effectively facilitate treatment-related decisions for with PCa. RNA sequencing data corresponding clinical were downloaded from Cancer Genome Atlas (TCGA)...
The tumor microenvironment (TME) exerts a high impact on biology and immunotherapy. heterogeneous phenotypes the clinical significance of CD8+ T cells in TME have not been fully elucidated. Here, comprehensive immunogenomic analysis based multi-omics data was performed to investigate heterogeneity between cell-related molecular clusters. We identified two distinct clusters ccRCC (C1 C2) TCGA validated E-MTAB-1980 cohorts. C1 cluster characterized by unfavorable prognosis, increased...
Long noncoding RNAs (lncRNAs) have been shown to be involved in the development of osteoarthritis. However, expression, function, and mechanism DLEU1 OA remain largely unclear. The present reference demonstrates that is overexpressed specimens compared control cartilages. Inflammatory cytokines IL-1β, TNF-α, IL-6 induce expression chondrocytes. Ectopic induces chondrocyte proliferation, degradation ECM, inflammation mediators such as IL-6, IL-8, TNF-α secretion. Moreover, we demonstrated...
Increasing evidence has indicated a close relationship between diabetes mellitus (DM) and disc degeneration. As potential therapeutic growth factor, osteogenic protein-1 (OP-1) lots of protective effects on the healthy cell's biology. The present study was aimed to investigate OP-1 degenerative changes nucleus pulposus (NP) cells in high glucose culture. Rat NP were cultured baseline medium or (0.2 M) culture medium. added into whether its some against cell apoptosis ratio, caspase-3/9...
Biochemical recurrence (BCR) is considered a decisive risk factor for clinical and the metastasis of prostate cancer (PCa). Therefore, we developed validated signature which could be used to accurately predict BCR aid in selection PCa treatments.A comprehensive genome-wide analysis data concerning from previous datasets Cancer Genome Atlas (TCGA) gene expression omnibus (GEO) was performed. Lasso Cox regression analyses were performed develop validate novel help risk. Moreover, nomogram...
Accumulating evidence shows that circRNAs play critical roles in the development of human tumors. We observed circ_0000527 was overexpressed osteosarcoma cells (SAOS-2, HOS, MG-63 and U2OS) compared hFOB1.19 cells. demonstrated level higher specimens than non-tumor specimens. The ectopic expression shown to induce cell growth, cycle progression secretion inflammatory mediators, including IL-1β, IL-6, IL-8 TNF-α. sponges miR-646 ARL2 is a target gene miR-646. MiR-646 decreased Overexpression...
Clear cell renal carcinoma (ccRCC) is the most common subtype of whose pathogenesis not well understood. We aimed at identifying novel immune-related biomarkers that could be valuable in diagnosis and prognosis ccRCC. The Robust Rank Aggregation (RRA) method was used to integrate differently expressed genes (DEGs) 7 Gene Expression Omnibus (GEO) datasets obtain robust DEGs. Weighted gene co-expression network analyses (WGCNA) were performed identify hub associated with clinical traits Cancer...
Background: Claspin (CLSPN) expression is acknowledged as a poor clinical prognostic factor in various tumors. However, the characteristics and biological functions of CLSPN prostate ca...
Background and Objective: Several positions have been described for percutaneous nephrolithotomy (PCNL). The aim of this study was to compare the safety effectiveness traditional prone position PCNL (TP-PCNL) split-leg (PSL-PCNL). Patients Methods: A retrospective review made data 212 patients who underwent in PSL or TP between January 2017 November 2019. demographic preoperative clinical were used propensity score-matching (PSM). Following PSM based on a multivariable logistic regression...
Background: Clear cell renal carcinoma (ccRCC) is the most common subtype of (RCC), which accounts for majority RCC-related deaths. It clearly essential to further identify more novel prognostic signatures and therapeutic targets. Material Methods: We identified differentially expressed genes (DEG) be-tween ccRCC adjacent normal tissue in GEO database using Robust Rank Ag-gregation (RRA) method. A mRNA signature (mRNASig) based on DEGs was devel-oped Cox LASSO analysis TCGA validated ICGC...