A5101665300- Kidney Stones and Urolithiasis Treatments
- Urinary Tract Infections Management
- Cancer Immunotherapy and Biomarkers
- Advanced X-ray and CT Imaging
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Therapeutic Uses of Natural Elements
- Environmental and Agricultural Sciences
- Pediatric Urology and Nephrology Studies
- Remote Sensing and Land Use
- Forest, Soil, and Plant Ecology in China
- Environmental Changes in China
- Connexins and lens biology
- Inflammatory Biomarkers in Disease Prognosis
- CAR-T cell therapy research
- Berberine and alkaloids research
- Biological Stains and Phytochemicals
- Nanoplatforms for cancer theranostics
- Chemokine receptors and signaling
- PARP inhibition in cancer therapy
- Sex and Gender in Healthcare
- Anesthesia and Pain Management
- Cancer, Hypoxia, and Metabolism
- Heat shock proteins research
- Selenium in Biological Systems
Second Affiliated Hospital of Guangzhou Medical University
2021-2025
Guangzhou Medical University
2014-2025
First Affiliated Hospital of Guangzhou Medical University
2018-2025
Tianjin Medical University Cancer Institute and Hospital
2023-2024
Key Laboratory of Guangdong Province
2022
Yinchuan First People's Hospital
2021
Guangzhou Institute of Dermatology
2018
Beijing Building Construction Research Institute (China)
2012
Agency of Rural Development and Soil and Water Conservation
2009
Tongliao Academy of Agricultural Sciences
2009
Hyperoxaluria, including primary and secondary hyperoxaluria, is a disorder characterized by increased urinary oxalate excretion could lead to recurrent calcium kidney stones, nephrocalcinosis eventually end stage renal disease. For high dietary (HDOx) or its precursors intake key reason. Recently, accumulated studies highlight the important role of gut microbiota in regulation homeostasis. However, underlying mechanisms involving metabolite disruptions hyperoxaluria remain poorly...
It is urgent to develop an alternative dynamic therapy-based method overcome the limited efficacy of traditional therapy methods for bladder cancer and damage caused patients. Sonodynamic (SDT) has advantages high tissue penetration, spatiotemporal selectivity, being non-invasive, representing emerging eradicating deep solid tumors. However, effectiveness SDT often hindered by inefficient production reactive oxygen species nondegradability sonosensitizer. To improve anti-tumor effect on...
Purpose: Prostate cancer (PCa) is often considered as a âcoldâ tumor with low responsiveness to immunotherapy. Recent evidence suggests the activation of specific immune cells, such tumor-associated macrophages (TAMs), could potentially influence efficacy immunotherapy in PCa. However, relationship between TAMs and PD-L1, significant regulator immunotherapy, within PCa remains unexplored. Methods: In this study, we assessed TAM infiltration PD-L1 expression levels local cohort 95 tissue...
Kidney stones, which have high prevalence and recurrence rates, often cause severe oxidative damage inflammation. The ultrasmall hydrodynamic diameter of nanoparticles is crucial for their enrichment in the kidneys to exert biological activity. However, integrating crystallization inhibition therapeutic functions into a single nanoparticle challenging. A novel iron (Fe)-gallic acid (Ga) metal-phenolic networks (Fe-Ga MPNs) developed treating calcium oxalate (CaOx) nephropathies. These MPNs...
Oxidative stress damage to renal epithelial cells is the main pathological factor of calcium oxalate calculi formation. The development medicine that could alleviate oxidative has become key prevention and treatment urolithiasis. Herein, porous nanorods CeO
Escherichia coli (E. coli) strains cause the majority of urinary tract infections (UTIs) and are resistant to various antibiotics. Therefore, it is imperative explore novel host-target therapies. As a famous food condiment, garlic (Allium sativum L.) widely used in medicine, but its exact key targets UTIs remain elusive. To identify major active ingredient molecular target against UTIs, network pharmacology analysis was carried out, allicin revealed be component acting on UTIs. By docking,...
Coptis chinensis Franch (CCF) is extensively used in the treatment of inflammatory-related diseases. Accumulating studies have previously demonstrated anti-inflammatory properties CCF, yet data on its exact targets against urinary tract infections (UTIs) remain largely unknown. Therefore, present study decodes potential action CCF UTIs by network pharmacology combined with experiment evaluations. Based analysis, current yielded six core ingredients: quercetin, palmatine (R)-canadine,...
In this study, we constructed a model using Cox proportional hazards based on the expression of eight immune-related genes that were associated with prognosis in prostate cancer: EDNRB, ANGPTL2, TNFSF15, TNFRSF10D, EDN2, BMP2, NLRP14, and PLK1. We then identified associations between risk scores calculated model, tumor microenvironment characteristics, immune cell infiltration. Prostate cancer patients high score group had poorer prognoses, validation external GSE54460 dataset confirmed...
Abstract Renal calculus is a global common urological disease that closely related to crystal adhesion and renal tubular epithelial cell impairment. Gap junctions (GJs) their components (connexins Cxs) are involved in various pathophysiology processes, but roles calculi progression not well defined. Our previous RNA microarray analysis suggests GJs one of the key predicted pathways calcium oxalate (CaOx) rat model. In current study, we found Cx43 Cx32 expression GJ function decreased...
Introduction: Urinary tract infection (UTI) should be treated before percutaneous nephrolithotomy (PCNL). However, the most appropriate treatment strategy in patients with negative urine culture but positive dipstick test (positive urinary leukocyte or nitrite reaction) remains unclear. Materials and Methods: From August 2016 to February 2018, 806 consecutive who had undergone first-stage PCNL were included. Preoperative urinalysis, antibiotic treatment, intraoperative stone culture,...
Due to the molecular heterogeneity, most bladder cancer (BLCA) patients show no pathological responses immunotherapy and chemotherapy yet suffer from their toxicity. This study identified validated three distinct stable clusters of BLCA in cross-platform databases based on personalized immune inflammatory characteristics. H&E-stained histopathology images confirmed infiltration cells among clusters. Cluster-A was characterized by a favorable prognosis low but showed highest abundance...
Prostate cancer (PCa) progression depends on the action of androgen receptors (AR). Therefore, preventing ligand-mediated activation AR is first-line treatment strategy for metastatic PCa. Androgen deprivation therapy (ADT) can inhibit ligand binding to and alleviate PCa initially. However, due adaptation recovery signaling, castration-resistant prostate (CRPC) eventually develops. Exploring novel dietary compounds that target signaling appears be a viable alternative therapeutic option...
Correct perioperative antibiotic strategies are crucial to prevent postoperative infections during percutaneous nephrolithotomy (PCNL). We aimed compare the realistic applied in China with current urological guidelines. Between April and May 2020, urologists from were invited finish an online cross-sectional survey. The questionnaire was designed according guidelines literatures. 3393 completed responses received. 61.1% (2073/3393) respondents had experience of more than 10 years. 72.4%...
The roles of Connexin43 (Cx43) in clear cell renal carcinoma (ccRCC) microenviroment remains to be poorly defined.The expression profile, prognosis and immune analysis Cx43 various cancers, particularly ccRCC were performed using TCGA database, biological function assays applied explore the physiological role tangeretin ccRCC. Western blot examine protein Kunming mice used evaluate preliminary safety or anti-tumor activity sunitinib.Compared with normal group, higher levels ccRCC, distinct...
Objective To develop some management strategies and to provide references for rationally using drugs investigating preventive use of analgesics before ESWL.Methods 80 patients undergoing ESWL were selected from our hospital January June,2013; among which 40 took meperidine the other tramadolin.The situation rationality peri-operative evaluated.Results The utilization rate was 100％ at hospital.Meperidine has same analgesic effect as tramadolin ESWL.Conclusions Tramadolin are both effective...