A5101465324- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Chromatin Remodeling and Cancer
- Endometriosis Research and Treatment
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- Biomarkers in Disease Mechanisms
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Endometrial and Cervical Cancer Treatments
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Cardiac tumors and thrombi
- Bladder and Urothelial Cancer Treatments
- Nanoparticles: synthesis and applications
- Urinary and Genital Oncology Studies
- Peptidase Inhibition and Analysis
- Viral-associated cancers and disorders
University of Science and Technology of China
2019-2023
Southern Medical University
2023
Nanfang Hospital
2023
Anhui Provincial Hospital
2016-2019
Anhui Medical University
2016
Cancer cells display phenotypic equilibrium between the stem-like and differentiated states during neoplastic homeostasis. The functional mechanistic implications of this subpopulation plasticity remain largely unknown. Herein, it is demonstrated that breast cancer stem cell (BCSC) secretome autonomously compresses population. Co-implantation with BCSCs decreases tumor-initiating capacity yet increases metastasis accompanying cells, wherein DKK1 identified as a pivotal factor secreted by for...
Colorectal cancer (CRC) remains a challenging and deadly disease with high tumor microenvironment (TME) heterogeneity. Using an integrative multi-omics analysis artificial intelligence-enabled spatial of whole-slide images, we performed comprehensive characterization TME in colorectal (CCCRC). CRC samples were classified into four CCCRC subtypes distinct features, namely, C1 as the proliferative subtype low immunogenicity; C2 immunosuppressed terminally exhausted immune characteristics; C3...
Dysregulation of SLC34A2 (NaPi2b) in tumors has attracted wide attention, but its expression and function non–small cell lung cancer remains unclear. By examining adenocarcinoma correlation to patient outcome, we aimed explore prognostic therapeutic values this deadly disease. Overall, 175 cases sample were included study. Histological subtyping them was diagnosed according standards the International Association for Study Lung Cancer/American Thoracic Society/European Respiratory Society...
The present study was designed to investigate the prognostic significance of preoperative sensitive-modified Glasgow score (S-mGPS) and its superiority in esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, albumin C-reactive protein (CRP) levels were retrospectively collected 442 patients who underwent transthoracic esophagectomy. S-mGPS calculated before surgery based on optimal cutoff values 45.6 g/L for 10.0 mg/L CRP. 360, 74 8 cases assigned an mGPS 0, 1 2,...
The present study was to establish a prognostic indicator based on preoperative fibrinogen and C-reactive protein (CRP) (FC score) in esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, plasma serum CRP levels were reviewed patients who underwent transthoracic esophagectomy. optimal cut-off value for defined as 4.0 g/dL 10.0 mg/L according previous reports. Patients with elevated assigned score of 2, those only one these two abnormalities allocated 1, neither the 0....
Triple-negative breast cancer (TNBC) has the poorest prognosis among all subtypes. While several tumor types are excepted to have a curative response immunotherapy through AT-rich interaction domain 1A (ARID1A) gene, its role in TNBC remains unclear.The expression of ARID1A gene and immune infiltration were analyzed by way function enrichment analysis. Additionally, 27 mutations, including mutation, detected paraffin-embedded specimens normal using Next Generation Sequencing (NGS)....
Side Population (SP) cells are the small pool of CSC like progenitor cells, which drug resistant and recapitulate tumor generation. The occurrence SP is major inference for attaining a better treatment improved patient survival. In this work, we have isolated 6% from high grade ovarian carcinoma. Our functional characterization revealed that elevated ABCG2 anti-apoptotic factors contribute to chemoresistance increased life span cells. Further, overexpression surface antigens, such as CD133...
To investigate the relationship between expression of C-MYC protein and clinicopathologic characteristics in angioimmunoblastic T-cell lymphoma (AITL), then discuss prognosis.Patient samples were collected made into tissue microarray for same experimental condition. Pathomorphological features immunohistochemistry specific markers used to determine diagnosis AITL. Epstein-Barr virus (EBV) infection was detected by EBV-encoded small RNA situ molecular hybridizations. B cells atypical...
Background The purpose of our research was to explore the value preoperative CT and MRI examinations clinical indicators in prediction recurrence ovarian serous carcinoma patients who underwent satisfactory staging surgery. Procedure Detailed inclusion exclusion criteria were installed screen all collected eligible divided into two groups. features some characteristics groups analyzed, addition, apparent diffusion coefficient (ADC) tumor solid region measured. Univariate analysis used this...