A5069467112- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
- Musculoskeletal synovial abnormalities and treatments
- Systemic Sclerosis and Related Diseases
- Viral Infections and Immunology Research
- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peripheral Neuropathies and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Myofascial pain diagnosis and treatment
- HER2/EGFR in Cancer Research
- Biosimilars and Bioanalytical Methods
- Toxin Mechanisms and Immunotoxins
- Medical and Biological Ozone Research
- Health Promotion and Cardiovascular Prevention
- Actinomycetales infections and treatment
Cliniques Universitaires Saint-Luc
2013-2024
UCLouvain
2007-2024
Center for Rheumatology
2018
Abstract Objective Synovitis is a common feature of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), but the pattern joint involvement differs in each disease. This study was undertaken to investigate global gene expression profiles synovial biopsy tissue from swollen knees untreated SLE patients (n = 6), RA 7), osteoarthritis (OA) 6). Methods Synovial samples were obtained affected 3 groups by needle arthroscopy. Half material used for extraction total RNA, amplification...
Abstract Objective To compare the effects of methotrexate (MTX), alone or in combination with intravenous (IV) methylprednisolone (MP) infliximab, on magnetic resonance imaging (MRI)–detected synovitis, bone edema, and erosive changes patients early rheumatoid arthritis (RA). Methods Forty‐four RA were randomized to receive MTX (MTX group), plus IV MP (IV infliximab (infliximab infused day 0 weeks 2, 6, 14, 22, 30, 38, 46. Gadolinium‐enhanced MRI scans metacarpophalangeal joints, wrists,...
Abstract Introduction To identify markers and mechanisms of resistance to adalimumab therapy, we studied global gene expression profiles in synovial tissue specimens obtained from severe rheumatoid arthritis (RA) patients before after initiation treatment. Methods Paired biopsies were the affected knee 25 DMARD (disease-modifying antirheumatic drug)-resistant RA at baseline (T0) 12 weeks (T12) therapy. DAS28-CRP (disease activity score using 28 joint counts-C-reactive protein) scores...
Objective To investigate the global molecular effects of tocilizumab (TCZ) in comparison with methotrexate (MTX) treatment synovial biopsy tissue obtained from patients previously untreated rheumatoid arthritis (RA) before therapy (T0) and 12 weeks after initiation (T12), to compare results previous gene expression data adalimumab (ADA)– rituximab (RTX)–treated RA. Methods Paired samples were at T0 T12 affected knee TCZ‐treated RA MTX‐treated patients. Gene studies performed using GeneChip...
Plasma and synovial myeloperoxidase (MPO) its products were strongly associated with osteoarthritis (OA) rheumatoid arthritis (RA). In addition, it is well known that there a link between oxidative stress cytokines. The present study aims at investigating the MPO (and products), interleukin (IL)-18, which involved in degradation of articular cartilage RA, IL-8, recruitment activation neutrophils during inflammation. Effects treatment RA on biological parameters also investigated.Patients (n...
Objectives Early diagnosis of rheumatoid arthritis (RA) is an unmet medical need in the field rheumatology. Previously, we performed high-density transcriptomic studies on synovial biopsies from patients with arthritis, and found that gene expression profiles were significantly different according to underlying disorder. Here, wanted further explore consistency signals using low-density platforms. Methods Low-density assays (cDNA microarray microfluidics qPCR) designed, based results data....
Transcriptomic profiling of synovial tissue from patients with early, untreated rheumatoid arthritis (RA) was used to explore the ability unbiased, data-driven approaches define clinically relevant subgroups.RNASeq performed on 74 samples, disease activity data collected at inclusion. Principal components analysis (PCA) and unsupervised clustering were patient clusters based expression most variable genes, followed by pathway inference relative abundance immune cell subsets. Histological...
To compare the short term clinical and biological effects of intravenous (i.v.) pulse methylprednisolone (MP) infliximab (IFX) in patients with severe active rheumatoid arthritis (RA) despite methotrexate (MTX) treatment.Patients RA MTX treatment were randomly allocated to receive a single i.v. infusion MP (1 g) or three infusions IFX (3 mg/kg) on weeks 0, 2, 6. Patients "blindly" evaluated for disease activity measures. Quality life (QoL) was through SF-36 health survey. Serum matrix...
Rituximab displays therapeutic benefits in the treatment of patients with rheumatoid arthritis (RA) resistant to tumor necrosis factor (TNF) blockade. However, precise role B cells pathogenesis RA is still unknown. We undertook this study investigate global molecular effects rituximab synovial biopsy samples obtained from anti-TNF-resistant before and after administration drug.Paired were affected knee (time 0) 12 weeks 12) initiation therapy. Total RNA was extracted, labeled according...
Apremilast is approved for the treatment of psoriasis and psoriatic arthritis (PsA). Real-world evidence on efficacy safety apremilast in clinical practice limited. We assessed use patients with PsA Belgium practice. The multicentre, observational, prospective APOLO study enrolled active initiating between April 2017 December 2018. Primary outcome was Response Criteria (PsARC) after 6 months treatment. Secondary outcomes included Impact Disease 12 (PsAID12) Health Assessment Questionnaire...
Glucocorticoid (GC)-induced osteoporosis contributes to chronic damage in patients suffering from connective tissue diseases (CTD) such as systemic lupus erythematosus (SLE). In this study, performed an highly selected cohort of premenopausal female CTD (mostly lupus) patients, given high-dose GC therapy for severe disease, we show that lumbar spine bone loss can be averted by treatment with oral disodium pamidronate combined calcium salts and vitamin D3 supplements not alone. We stress the...
Objectives We explored histological and transcriptomic profiles of paired synovial biopsies from rheumatoid arthritis (RA) patients, in order to assess homogeneity tissue at the individual level. Methods Synovial were performed simultaneously one small large joint per patient using needle-arthroscopy for knee ultrasound-guided biopsy hand or wrist. Synovium individuals with osteoarthritis was used as controls. Paraffin-embedded samples stained CD3, CD20, CD68. Total RNA hybridized on...
Abstract Objectives To characterize the frequency of PsA subtypes, estimate severity based on damage and inflammation impact patients’ health-related quality life. Methods We conducted a longitudinal observational study in 17 academic non-academic centres Belgium. Patients with fulfilling Classification Criteria for Psoriatic Arthritis were recruited. Three visits scheduled: at baseline (T0), 1 year (±1 month; T1) 2 years T2) follow-up. Demographics, clinical data patient-reported outcome...
Abstract Background/purpose Studies have demonstrated that rheumatoid arthritis (RA) patients who achieve low disease activity or remission are able to taper biological disease-modifying antirheumatic drugs (bDMARDs). The aim of this study was evaluate the proportion in whom bDMARDs can be tapered daily practice and analyse characteristics these patients. Other objectives were which more suitable for dose reduction cost savings. Results Data from 332 eligible RA our Brussels UCLouvain cohort...
The objective is to characterize transcriptomic profiles and immune cell composition distribution in juvenile idiopathic arthritis (JIA) synovial biopsies, assess for associations of these features with clinical parameters, compare JIA rheumatoid (RA) features.