A5067261288- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Neurological Disorders and Treatments
- Trypanosoma species research and implications
- Receptor Mechanisms and Signaling
- Cerebrospinal fluid and hydrocephalus
- Pain Management and Placebo Effect
- Advanced Neuroimaging Techniques and Applications
- Vagus Nerve Stimulation Research
- Photoreceptor and optogenetics research
- Fetal and Pediatric Neurological Disorders
- Epigenetics and DNA Methylation
- Pharmacological Effects and Toxicity Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Pneumocystis jirovecii pneumonia detection and treatment
- Nicotinic Acetylcholine Receptors Study
- Heme Oxygenase-1 and Carbon Monoxide
- Potassium and Related Disorders
- Neurological diseases and metabolism
- Genetics and Neurodevelopmental Disorders
- Cardiac Arrest and Resuscitation
Methodist Hospital
2019-2022
Houston Methodist
2019-2021
Neurological Research Institute
2015-2020
Baylor College of Medicine
2014-2020
Oxford University Press (United Kingdom)
2020
Texas Children's Hospital
2015-2020
University of Mississippi Medical Center
2005-2017
STMicroelectronics (France)
2015
Université Paris Cité
2005-2010
Jackson Memorial Hospital
2005
Summary Objective Hyperactivation of the mechanistic target rapamycin (m TOR ; also known as mammalian rapamycin) pathway has been demonstrated in human cortical dysplasia ( CD ) well animal models epilepsy. Although inhibition m signaling early epileptogenesis suppressed epileptiform activity neuron subset‐specific Pten knockout NS ‐ P ten KO mouse model , effects after epilepsy is fully established were not previously examined this model. Here, we investigated whether suppresses and other...
Inflammatory conditions characterized by excessive peripheral immune responses are associated with diverse alterations in brain function, and brain-derived neural pathways regulate inflammation. Important aspects of this bidirectional immune-brain communication, including the impact inflammation on region-specific cytokine responses, cholinergic signaling (which plays a role controlling levels), remain unclear. To provide insight, we studied gene expression cytokines, cell markers system...
Recently, it was proposed that CSF flow constitutes a critical part of the glymphatic system, playing role in various brain abnormalities from Alzheimers disease to hydrocephalus. Thus, measurement has been increasingly used for diagnostic and clinical monitoring purposes. Phase-contrast MRI determine flow. However, periarterial spaces circle Willis middle cerebral artery which are important conduits remain unexplored. We employed phase-contrast explore along perivascular establish baseline...
We observed fine fibrin deposition along the paravascular spaces in naive animals, which increased dramatically following subarachnoid hemorrhage (SAH). Following SAH, deposits areas remote from hemorrhage. Traditionally it is thought that fibrinogen enters space through damaged blood brain barrier. However, of remotely suggests chains Aα, Bβ, and γ can originate brain. Here we demonstrate vivo vitro astroglia neurons are capable expression chains. SAH mice was induced by filament...
The goal of these studies was to use quantitative (q)EEG techniques on data from children with Angelman syndrome (AS) using spectral power analysis, and evaluate this as a potential biomarker method therapeutics. Although characteristic patterns are evident in visual inspection, qEEG has the provide evidence treatment efficacy. We first assessed baseline EEG recordings collected AS compared age-matched neurotypical controls, which corroborated previously reported finding increased total...
Recently we reported that intrathalamic microinjection of carbachol triggers generalized convulsive seizures (GCS) followed by severe inflammatory response including edema, microhemorrhages, and subsequent degeneration amygdaloallocortical area. Our further observations increased expression tumor necrosis factor alpha (TNF-α) interleukin (IL)-1β immunoreactivity (IR) confirmed the nature brain damage following GCS. In presented experiments, addressed possible effects a nonspecific...
Excitation of intrinsic neurons cerebellar fastigial nucleus (FN) renders brain tolerant to local and global ischemia. This effect reaches a maximum 72 h after the stimulation lasts over 10 days. Comparable neuroprotection is observed following sublethal ischemia, phenomenon known as preconditioning. We hypothesized that FN may participate in mechanisms ischemic preconditioning part neuroprotective mechanism. To explore potential significance tolerance we lesioned with excitotoxin ibotenic...
After subarachnoid hemorrhage (SAH), up to 95% of surviving patients suffer from post-SAH syndrome, which includes cognitive deficits with impaired memory, executive functions, and emotional disturbances. Although these long-term are thought result damage temporomesial–hippocampal areas, the underlying mechanisms remain unknown . To fill this gap in knowledge, we performed a systematic RNA sequencing screen hippocampus mouse model SAH. SAH was induced by perforation circle Willis mice. Four...
Abstract Brain cholinergic signaling regulates peripheral cytokine release and inflammation (Nat Rev Endocrinol, 2012, 8:743). We have previously shown that the centrally-acting acetylcholinesterase inhibitor galantamine suppresses pro-inflammatory through a brain muscarinic receptor-mediated vagus nerve-dependent mechanism. Here, we provide insight into mechanisms of this regulation. VAChTNkx21-Cre-flox/flox mice with selective, basal forebrain neuron genetic ablation vesicular...
Regnier-Golanov, Angelique; Hernandez, Magda S; Golanov, Eugene MD, PhD; Britz, Gavin W MD Author Information
Regnier-Golanov, Angelique; Dundar, Friederike; Zumbo, Paul; Betel, Doron; Golanov, Eugene MD, PhD; Britz, Gavin W MD Author Information