A5074579239- Multiple Myeloma Research and Treatments
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Parasites and Host Interactions
- Infant Nutrition and Health
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Digestive system and related health
- Renal Diseases and Glomerulopathies
- Psoriasis: Treatment and Pathogenesis
- Cancer Treatment and Pharmacology
- GDF15 and Related Biomarkers
- Parasite Biology and Host Interactions
- Immunodeficiency and Autoimmune Disorders
- Probiotics and Fermented Foods
- Tuberculosis Research and Epidemiology
- Cytokine Signaling Pathways and Interactions
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Child Nutrition and Water Access
- Epigenetics and DNA Methylation
Universidade Federal de Pernambuco
2014-2023
Hospital das Clínicas da Universidade Federal de Pernambuco
2020
BACKGROUND Breastfeeding or gestation in schistosomotic mothers can cause long-term alterations the immune response of offspring. OBJECTIVES Evaluate expression histone deacetylases (HDACs) (all classes), production cytokines by T and B lymphocytes macrophages, frequency CD4+CD25+FoxP3+-cells adult offspring born and/or suckled mothers. METHODS We harvested splenocytes from to (BIM), (SIM), to/suckled (BSIM) animals noninfected (Control) at seven-weeks old cultured them with/without...
Background Tuberculosis screening in psoriasis patients is complex due to the immunological alterations associated with psoriasis, presence of comorbidities, and effect immunosuppressive treatment. However, it not established whether results tests are affected by these factors patients. Objectives To determine there a change tuberculin skin test (TST) or interferon-gamma release assay (IGRA) living tuberculosis (TB)-endemic area after 12 weeks methotrexate (MTX) treatment investigate...
Abstract In experimental autoimmune hepatitis (EAH) of Th1 profile, an extract adult Ascaris suum worms (ASC) was previously found to deviate the immune response a Th2/IL-10 pattern. Here, effects treatment with ASC on production TGF-β and anti-Ascaris isotypes IgG1 IgG2a in EAH were evaluated. induced BALB/c mice, intravenously concanavalin A. Two hours later, these animals received (EAH+ASC group) or PBS vehicle (EAH group). evaluated 8 h, 24 h 7 d after induction. measured splenocyte...
INTRODUCTION Suckling by schistosomotic mice improves anti-ovalbumin (OA) antibody production, while delayed-type hypersensitivity (DTH) remains unaffected. This property of milk from was investigated in IL-12/IL-23-deficient (IL-12p40KO). METHODS We compared anti-OA DTH, IgG2a and cytokines wild-type IL-12p40KO suckled infected (SIM) or non-infected (CONTROL) mothers. RESULTS SIM showed similar intensity eosinophils the which abolished IL-12p40KO-SIM mice. In IL-12p40KO-SIM, TGF-β levels...
<div>Abstract<p>Multiple myeloma remains treatable but incurable. Despite a growing armamentarium of effective agents, choice therapy, especially in relapse, still relies almost exclusively on clinical acumen. We have developed system, <i>Ex vivo</i> Mathematical Myeloma Advisor (EMMA), consisting patient-specific mathematical models parameterized by an <i>ex assay that reverse engineers the intensity and heterogeneity chemosensitivity primary cells from...
<p>Individual patient EMMA predicitons of actual responses to therapy (companion Figure 3i).</p>
<p>Supplemental Figures and Tables to augment (1) the mathematical modeling (providing details on specific therapeutics); (2) patient characteristics (treatment history, clinical predicted response), (3) synergistic activities identified by EMMA; (4) data processing guides</p>