Abstract Systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, was recently investigated as a prognostic marker in several tumors. However, SII has not been reported esophageal squamous cell carcinoma (ESCC). We evaluated the value of 916 patients with ESCC who underwent radical surgery. Univariate multivariate analyses were calculated by Cox proportional hazards regression model. The time-dependent receiver operating characteristics (ROC)...

Abstract Aim Systemic inflammatory response is closely related to tumor progression. We retrospectively investigated relationships between systemic scores, C‐reactive protein/albumin (CRP/Alb) ratio (CAR) and clinical characteristics in advanced non–small‐cell lung cancer (NSCLC) 436 patients find better predictors of NSCLC prognosis. Methods Blood specimens were collected 1 week before treatment test for scores albumin. Patients’ overall survival (OS) was calculated via Kaplan–Meier method....

Aim: We aimed to explore the effect of long noncoding RNA HCG18 in colorectal cancer (CRC). Materials & methods: Relative gene and protein expression were screened. Colony formation flow cytometry assays performed determine proliferation apoptosis. Dual luciferase immunoprecipitation conducted validate interaction between indicated molecules. Xenograft nude mice was applied verify conclusion vivo. Results: PD-L1 upregulated while miR-20b-5p downregulated CRC tissue. Functional analysis...

The inflammatory microenvironment plays an important role in the onset and progression of lung adenocarcinoma (LUAD), liver is a suitable site metastasis for LUAD cells. However, whether conducive to proliferation, invasion, cells remains unclear. In this study, we confirmed that hepatic stimulated by IL-6 promoted migration, epithelial-mesenchymal transition cells, increased m6A methylation total RNA, transcriptionally activated METTL3 expression. Additionally, YAP1/TEAD signaling pathway...

To assess the prognostic value of mediastinal lymph node metastases (N2 disease), carcinoembryonic antigen (CEA) levels and C-reactive protein (CRP) in non-small cell lung cancer (NSCLC), according to 7th edition TNM classification.Newly diagnosed stage III-IV NSCLC were enrolled, including 75 patients with malignant pleural effusion. The relationship between serum CRP other relevant variables such as sex, Eastern Cooperative Oncology Group status, smoking initial staging, N2 disease,...

The present study aimed to explore the relationships between distribution of abdominal fat and muscle age gender in a middle-aged elderly population.The levels (visceral subcutaneous) fat, pericardial psoas major were measured subjects who had physical examinations at Health Medical Department Peking Union College Hospital from July 2019 June 2020. relationship different areas (ie, types fat) investigated context genders ages.The differed males females sample. Volumes total visceral...

To explore if vascular endothelial growth factor receptor-3 (VEGFR-3) and carcinoembryonic antigen (CEA) can predict overall survival in advanced gastric cancer.VEGFR-3 level was assessed by enzyme-linked immunosorbent assay, CEA chemiluminescence immunoassay the sera of 81 cancer patients before treatment with oxaliplatin plus 5-fluorouracil folinic acid.Median time a low serum VEGFR-3 significantly longer than those higher (15.4 mo vs 7.7 mo, P < 0.001). Patients had (15.8 8.6 Thirty-nine...

The present study describes the use of bidirectional chemotherapy in treatment patients with gastric cancer and peritoneal carcinomatosis (PC), using newly developed response criteria for malignant ascites. In addition, association between effusion survival was analyzed. Between June 2010 May 2014, affected by ascites secondary to unresectable PC origin were treated a combination systemic loco‑regional chemotherapy. Cisplatin (75 mg/m2) at an inflow temperature 43˚C infused...

Objective: To investigate the associations between various blood test parameters including MLR (monocyte-lymphocyte ratio) and prognosis in post-operative esophagogastric junction cancer patients. Methods: We retrospectively studied preoperative postoperative data of 309 patients who underwent radical surgery for cancer. The relationship MLR, neutrophil lymphocyte ratio (NLR), platelet-lymphocyte (PLR) overall survival (OS) was analyzed. Results: cutoff values MLR、NLR PLR were 0.201, 1.697...

The present study aimed to explore the relationship between non-alcoholic fatty liver disease (NAFLD) and abdominal pericardial adipose tissue in middle-aged elderly subjects.Between July 2019 2020, 471 subjects attending Health Care Medical Department of Peking Union College Hospital for a medical examination were enrolled study. volume distribution together with calculated according results computed tomography. differences NAFLD normal population analyzed.The tissue, visceral subcutaneous...

The present study discusses a patient with C1 vertebral metastasis from adenocarcinoma of the left lung. was 31-year-old female suffering neck pain who referred by her physician. Magnetic resonance imaging revealed osteolytic destruction vertebra. Chest and computed tomographic scans lung carcinoma changes involving A biopsy confirmed Abnormal activity in cervical spine (C1) region radionuclide bone scan. then to an oncologist. stabilized rigid collar course radiation therapy medication...

Abstract Rationale: Vulvar metastasis of colorectal cancer (CRC) and acquired resistance to cetuximab is a very rare phenomenon. To our knowledge, few cases have been reported in the English literatures. Patient concerns: A 55-year-old woman was diagnosed as adenocarcinoma rectum primary tumor detected be Kirsten-RAS (KRAS) wild type. Diagnoses: The patient with rectal by colonoscopy. Positron emission tomography/computed tomography (PET-CT) revealed multiple lymph node bone metastases....

Lynch syndrome (LS) is a genetic disorder mainly caused by germline mutations in mismatched repair (MMR) genes ( MSH2 , MLH1 MSH6 and PMS2 ) or deletions of the epithelial cell adhesion molecule gene EPCAM ). A 43-year-old Chinese male patient underwent radical surgery was pathologically confirmed to have stage IIIB colon adenocarcinoma. After four cycles standard adjuvant chemotherapy, tumor reoccurred situ with intestinal obstruction. The received secondary colectomy. Immunohistochemistry...

With the emerging of aging society and advances information sciences, telemedicine has gradually become a new medical model. Telemedicine can be used in health monitoring, disease diagnosis, counseling, education, chronic management long-term care elderly population; particularly heart failure, diabetes other diseases, as well referral continuous care. To promote population break physical limitations different settings, so that geriatrician allied team members are enable to maximize their...

Soft tissue sarcoma is a relatively rare entity that comprises heterogeneous types of tumors. Here we report the case 14-year-old girl with pelvic YWHAE-NUTM2B fusion gene. This transcript has been reported in endometrial stromal sarcomas and clear cell renal sarcomas, but its description recent. To our knowledge, this first describing translocation an adolescent patient soft sarcoma. The underwent cytoreductive surgery, followed by systemic chemotherapy targeted drug treatment....

This manuscript has been withdrawn by the authors prior to final publication in journal.

Abstract Tumor suppressor gene BRCA1, known for its vital roles in regulating DNA damage, is frequently mutated hereditary breast and ovarian cancer (HBOC), whose mutation also increases susceptibility to intestinal, prostatic pancreatic cancers of patients. As the main subtype lymphoma, non-Hodgkin lymphoma (NHL) malignant disorders arising from immune cells displays predominantly as lymphadenopathy or solid tumors, which rarely considered hereditary. However, relationship between BRCA1 NHL...

Objective A analyze the relation between abdominal fat and diabetes mellitus in elderly person aged 51-100. Methods According to CT scan 2015 2016 of 162 patients Peking Union Medical College Hospital, volume distribution their were measured relationship mellitus. Results People 51-75, no abnormal glucose metabolism group compare with or fast hyperglycemia group, tend have less visceral fat[(63.61±24.95)mm3vs.( 70.39±31.33)mm3t=-1.229, P=0.22], more subcutaneous...

Objective To analyze the relationship between abdominal fat and progress of carotid atherosclerosis in subject ageing 51-100 years. Methods 140 subjects receiving health examination department Peking Union Medical College Hospital from 2015 to 2016 were included research. The area distribution calculated according CT, artery was determined by ultrasound. Results In population years old, there no statistically significant difference among plaque thickening group, arteriosclerosis...