Ryan C. O’Connell

ORCID: 0000-0003-0945-3631
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About
Contact & Profiles
Research Areas
  • Analytical Chemistry and Sensors
  • Electron Spin Resonance Studies
  • Advanced MRI Techniques and Applications
  • bioluminescence and chemiluminescence research
  • Free Radicals and Antioxidants
  • 3D Printing in Biomedical Research
  • Thermal and Kinetic Analysis
  • Chemical Reaction Mechanisms
  • Occupational exposure and asthma
  • Lanthanide and Transition Metal Complexes
  • Solid-state spectroscopy and crystallography
  • Microfluidic and Capillary Electrophoresis Applications
  • Conducting polymers and applications
  • Organic Light-Emitting Diodes Research
  • Indoor Air Quality and Microbial Exposure
  • Advanced NMR Techniques and Applications
  • Chemistry and Chemical Engineering
  • Inorganic and Organometallic Chemistry
  • Immune cells in cancer
  • Ovarian function and disorders
  • Immunotoxicology and immune responses
  • Cancer Cells and Metastasis
  • Analytical Chemistry and Chromatography
  • Hypothalamic control of reproductive hormones
  • Cancer, Hypoxia, and Metabolism

Dartmouth College
2024

West Virginia University
2019-2023

Centers for Disease Control and Prevention
2019-2022

Davis & Elkins College
2017-2019

California Department of Public Health
2019

National Institute for Occupational Safety and Health
2019

Abstract GM-CSF has been employed as an adjuvant to cancer immunotherapy with mixed results based on dosage. We previously showed that regulated tumor angiogenesis by stimulating soluble vascular endothelial growth factor (VEGF) receptor-1 from monocytes/macrophages in a dose-dependent manner neutralized free VEGF, and intratumoral injections of high-dose ablated blood vessels worsened hypoxia orthotopic polyoma middle T Ag (PyMT) triple-negative breast (TNBC). In this study, we assessed...

10.4049/jimmunol.2300326 article EN The Journal of Immunology 2023-09-27

Bioprinting is an additive manufacturing technology analogous to 3D printing. Instead of plastic or resin, cell-laden hydrogels are used produce a construct the intended biological structure. Over time, cells transform this into functioning tissue organ. The process printing followed by maturation referred as 4D bioprinting. fourth dimension temporal. Failure provide living with sufficient amounts oxygen at any point along developmental timeline may jeopardize bioprinting goals. Even...

10.1007/s11307-023-01871-0 article EN cc-by Molecular Imaging and Biology 2023-12-01

Puberty is a process that integrates multiple inputs ultimately resulting in an increase gonadotrophin‐releasing hormone (GnRH) secretion. Although kisspeptin neurones play integral role GnRH secretion and puberty onset, other systems are also likely important. One potential component nitric oxide (NO), gaseous neurotransmitter synthesised by synthase (NOS). The present study aimed to neuroanatomically characterise neuronal NOS (nNOS) prepubertal female sheep determine whether oestradiol...

10.1111/jne.12560 article EN Journal of Neuroendocrinology 2017-11-25

A plot of<graphic xmlns:xlink="http://www.w3.org/1999/xlink" id="ugt1" xlink:href="http://pubs.rsc.org/RA/2017/c7ra05260j/c7ra05260j-t1..gif"/><italic>vs. T</italic>for the acetonitrile/water system. Terms such as this one are crucial for a thermodynamic analysis of Eyring activation parameters.

10.1039/c7ra05260j article EN cc-by-nc RSC Advances 2017-01-01

Oxygen plays a critical role in the photopolymerization process resulting formation of solid structures from liquid resins during three-dimensional (3D) printing: it acts as polymerization inhibitor. Upon exposure to light, oxygen is depleted. As result, becomes activated. Electron paramagnetic resonance (EPR) imaging described tool visualize changes distribution caused by light exposure. This nondestructive method uses radio waves and, therefore, not constrained optical opacity offering...

10.1089/3dp.2020.0170 article EN 3D Printing and Additive Manufacturing 2021-07-29

Abstract This article presents reaction rate data for the simple hydrolysis of acetic anhydride in acetonitrile/water and acetone/water cosolvent systems regression analyses using recently developed thermodynamic equations that contain electrostatic solvent‐solute terms. The isomole fraction plots these are linear, previous theoretical work has shown term is negligible such systems. On other hand, rates dependent upon mole fraction, indicating term, which modeled empirically, significant....

10.1002/kin.21329 article EN International Journal of Chemical Kinetics 2019-10-31

Abstract This article presents the derivation of thermodynamic expressions for activation free energy and reaction rate constant cosolvent systems. These account factors that are specific to solution‐phase reactions, which include isotropic electrostatic effects close‐range solvent−solute interactions. discusses idea can be correlated with relative permittivity, interactions mole fraction. also shows this type analysis is necessary understanding certain nuances processes not tractable by...

10.1002/kin.21222 article EN International Journal of Chemical Kinetics 2018-10-01

With advances in nanotechnology, engineered nanomaterial applications are a rapidly growing sector of the economy. Some nanomaterials can reach brain through nose-to-brain transport. This transport creates concern for potential neurotoxicity insoluble and need toxicity screening tests that detect Such involve intranasal instillation aqueous suspensions dispersion media limit particle agglomeration. Unfortunately, protein some elements existing suboptimal because olfactory has size-...

10.1177/01926233221089209 article EN Toxicologic Pathology 2022-04-01
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