A5084592681- Surfactants and Colloidal Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Lipid Membrane Structure and Behavior
- Water Quality Monitoring Technologies
- Electrostatics and Colloid Interactions
- Nanopore and Nanochannel Transport Studies
- Advanced Polymer Synthesis and Characterization
- Dendrimers and Hyperbranched Polymers
- Enhanced Oil Recovery Techniques
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Cyclopropane Reaction Mechanisms
- Protein Structure and Dynamics
- Catalytic C–H Functionalization Methods
- Molecular spectroscopy and chirality
- Spectroscopy and Quantum Chemical Studies
- Wastewater Treatment and Nitrogen Removal
- Membrane Separation Technologies
- Catalytic Cross-Coupling Reactions
- CO2 Reduction Techniques and Catalysts
- Heat Transfer and Boiling Studies
- Chemical Synthesis and Reactions
- Electrochemical Analysis and Applications
- Oxidative Organic Chemistry Reactions
Centrum Wiskunde & Informatica
2025
University of Amsterdam
2023-2025
Novartis (Switzerland)
2021-2024
University of Helsinki
2023-2024
Université de Montpellier
2021
Centre National de la Recherche Scientifique
2021
A sustainable C(sp 2 )–C(sp 3 ) cross-electrophile coupling was developed between readily available 5-bromophthalide and 1-benzyl-4-iodopiperidine under micellar conditions, leading to a key intermediate of one our development compounds.
Peptides or proteins containing small biomolecular aggregates, such as micelles, bicelles, droplets and nanodiscs, are pivotal in many fields ranging from structural biology to pharmaceutics. Monitoring dynamics of systems has been limited by the lack experimental methods that could directly detect their fast (picosecond nanosecond) timescale dynamics. Spin relaxation times NMR experiments sensitive motions, but interpretation for aggregates is not straightforward. Here we show dynamic...
Abstract Cyclopropanes are valuable motifs in organic synthesis, widely featured pharmaceuticals and functional materials. Herein, we report an efficient electrochemical methodology for the cyclopropanation of alkenes, leveraging a nickel‐catalyzed process continuous‐flow. The developed protocol demonstrates broad substrate scope, accommodating both electron‐rich electron‐poor alkenes with high group tolerance. Beyond dichloromethane as feedstock methylene source, enables synthesis...
Cyclopropanes are valuable motifs in organic synthesis, widely featured pharmaceuticals and functional materials. Herein, we report an efficient electrochemical methodology for the cyclopropanation of alkenes, leveraging a nickel‐catalyzed process continuous‐flow. The developed protocol demonstrates broad substrate scope, accommodating both electron‐rich electron‐poor alkenes with high group tolerance. Beyond dichloromethane as feedstock methylene source, enables synthesis methylated,...
We report a metallaphotocatalytic strategy for the selective methylation of (hetero)aryl bromides via nickel-catalyzed cross-coupling with bis(trimethylaluminum)-1,4-diazabicyclo[2.2.2]octane (DABAl-Me₃), as commercially available, air-stable, and non-pyrophoric aluminum-based reagent. The method enables fast, robust, scalable protocol that broadly accommodates various functional groups while preventing protodehalogenation. Mechanistic studies confirm unprecedented generation methyl radicals...
Abstract A practical electrochemical method for synthesizing aryliminophosphoranes from widely available nitro(hetero)arenes in a continuous‐flow system is presented. The utilization of flow technology offers several advantages to our approach, including the elimination need supporting electrolyte and enhanced scalability. Our demonstrates good tolerance towards various functional groups, with electron‐deficient nitroarenes being particularly suitable this strategy. In addition, we have...
A robust and sustainable C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cross-electrophile coupling was developed <italic>via</italic> nickel/copper synergistic catalysis under micellar conditions.
Cyclic oxyterpenes are natural products that mostly used as fragrances, flavours and drugs by the cosmetic, food pharmaceutical industries. However, only a few cyclic accessible via chemical syntheses, which far from being ecofriendly. We report here synthesis of six derived ß-pinene while respecting principles green sustainable chemistry. Only or biosourced catalysts were in mild conditions optimised for each synthesis. A new generation ecocatalysts, Mn-rich water lettuce, was prepared...
Cyclopropanes are valuable motifs in organic synthesis, widely featured pharmaceuticals and functional materials. Herein, we report an efficient electrochemical methodology for the cyclopropanation of alkenes, leveraging a nickel-catalyzed process continuous-flow. The developed protocol demonstrates broad substrate scope, accommodating both electron-rich electron-poor alkenes with high group tolerance. Beyond dichloromethane as feedstock methylene source, enables synthesis methylated,...
Dynamic interactions between peptides and lipid membranes are crucial in many biological processes biomedical applications However, monitoring of peptide dynamics a membrane environment has been limited by the lack experimental methods that could directly detect fast (picosecond to nanosecond) timescale this environment. Spin relaxation times from nuclear magnetic resonance (NMR) experiments sensitive such motions, but their often complications sample preparation interpretation data. Here we...