A5100774344- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Nanoplatforms for cancer theranostics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Tracheal and airway disorders
- Synthesis and Catalytic Reactions
- Reconstructive Facial Surgery Techniques
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Asymmetric Hydrogenation and Catalysis
- Endodontics and Root Canal Treatments
- Asymmetric Synthesis and Catalysis
- Oral microbiology and periodontitis research
- Dysphagia Assessment and Management
- Hearing Loss and Rehabilitation
- Ear Surgery and Otitis Media
- Various Chemistry Research Topics
- Antimicrobial agents and applications
- Noise Effects and Management
- Chemical Synthesis and Reactions
- Hearing Impairment and Communication
Universidade Federal de São Carlos
2013-2024
Universidade Estadual de Campinas (UNICAMP)
2024
University of Amsterdam
2022-2023
Universidade Federal de Goiás
2016-2023
Texas Children's Hospital
2020-2022
Baylor College of Medicine
2020-2022
University of Florida
2011-2016
Colorado Permanente Medical Group
2012
Florida College
2012
Universidade de Ribeirão Preto
2007
Abstract Chiral hydrogen‐bond donors have played a crucial role in the progress of asymmetric catalysis as an essential tool modern organic synthesis. Among these donors, thioureas been found to be one most powerful systems organocatalytic approaches. Within last three years, new generation bifunctional thiourea catalysts has emerged effective way promote highly demanding chemical transformations, frequently with success rates that are intriguingly higher than other traditional thioureas....
While photochemical transformations with sunlight almost exclusively utilize the UV–vis part of solar spectrum, majority photons emitted by sun have frequencies in near-infrared region. Phthalocyanines show high structural similarity to naturally occurring light-harvesting porphyrins, chlorins, and mainly bacteriochlorins are also known for being efficient affordable light absorbers as well triplet sensitizers production singlet oxygen. Although having been neglected a long time synthetic...
A metal-free methodology for the photoarylation of pyridines, in water, is described giving 2 and 4-arylated-pyridines yields up to 96%. The scope aryldiazonium salts presented showing important results depending on nature position substituent group diazonium salt, that is, electron-donating or electron-withdrawing ortho, meta, para positions. Further heteroaromatics were also successfully photoarylated. Mechanistic studies comparison between our similar metal-catalyzed procedures are...
The efficient C-4 selective modification of pyridines is a major challenge for the synthetic community. Current strategies are plagued with at least one drawback regarding functional group-tolerant electronic activation heteroarene, mild generation required alkyl radicals, regioselectivity, safety and/or scalability. Herein, we describe fast, safe and scalable flow process which allows preparation said alkylated pyridines. involves photochemical hydrogen atom transfer (HAT) event to generate...
Abstract A practical electrochemical method for synthesizing aryliminophosphoranes from widely available nitro(hetero)arenes in a continuous‐flow system is presented. The utilization of flow technology offers several advantages to our approach, including the elimination need supporting electrolyte and enhanced scalability. Our demonstrates good tolerance towards various functional groups, with electron‐deficient nitroarenes being particularly suitable this strategy. In addition, we have...
Antimicrobial photodynamic therapy (aPDT) has been considered as a potential alternative to antibiotics for the treatment of biofilm infections. There is evidence that an additional H2O2 enhances antimicrobial efficacy aPDT. However, minimum concentration achieve this synergistic effect unclear. A saliva-derived multi-species was treated with photosensitizer chlorin e6 (Ce6, 50 µM), (0.3, 3.3, 33.3 mM), or their combination 5 min, followed by no irradiation at 15 J (cm2)−1 (λ = 450 nm 660...
In this study, direct C-H photoarylation of pyrazine with aryldiazonium salts under visible-light irradiation (blue-LEDs) is described, and additional examples including photoarylations pyrimidine pyridazine are also covered. The corresponding aryl-diazines were prepared in yields up to 84% only by mixing irradiating the reaction no need for an photocatalyst. We demonstrate efficacy protocol scope electron-donor, -neutral, -withdrawing groups attached at ortho, meta, para positions salts;...
Microtia reconstruction is technically challenging due to the intricate contours of ear. It common practice use a two-dimensional tracing patient's normal ear as template for affected side. Recent advances in three-dimensional (3D) surface scanning and printing have expanded ability create surgical models preoperatively. This study aims describe simple affordable process fabricate patient-specific 3D operating room.Applied basic research on novel optical fabrication pathway microtia...
An original total synthesis of the antiepileptic drug brivaracetam (BRV) is reported. The key step in consists an enantioselective photochemical Giese addition, promoted by visible-light and chiral bifunctional photocatalyst Δ-RhS. Continuous flow conditions were employed to improve efficiency allow easy scale-up reaction step. intermediate obtained from was converted into BRV two different pathways, followed one alkylation amidation, thus giving desired active pharmaceutical ingredients...
To determine the utility of performing balloon dilation laryngoplasty subglottic stenosis (SGS) in children with underlying congenital heart disease (CHD).Retrospective study.Tertiary care academic health center.Children an diagnosis CHD who subsequently underwent for SGS from January 1, 2006, through December 31, 2011.Clinical improvement and avoidance tracheotomy.We identified 16 had a direct laryngoscopy bronchoscopy. Five patients (3 girls 2 boys) total 11 dilations SGS. Their ages at...
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Objectives To determine the concentration of calcium, iron, manganese and zinc ions after application chelator to Enterococcus faecalis biofilms. Material Methods Fifty bovine maxillary central incisors were prepared inoculated with E. for 60 days. The following used as irrigation solutions: 17% EDTA (pH 3, 7 10), 2.5% sodium hypochlorite (NaOCl) combined distilled water NaOCl. Each solution was kept in root canal five minutes. Fifteen uncontaminated canals irrigated 10). Six teeth bacterial...
Apersistent foramen of Huschke, or tympanicum, results from the defective ossification anteroinferior aspect tympanic portion temporal bone. We describe 2 girls, aged 5 and 6 years, with histories recurrent cervical abscesses, draining submandibular sinuses, plates adjacent to ring. Surgical resection fistulous tract extending triangle bony ear canal successfully controlled symptoms.
Abstract Carboxymethyl C5-functionalized pyridine-oxazoline (PyOx) ligands are immobilized onto Merrifield and Wang resins utilizing three distinct strategies. The PyOx employed in the Pd-catalyzed heterogeneous Heck–Matsuda reaction for desymmetrization of 3-cyclopenten-1-ol, resulting production 20 examples aryl-penten-1-ols with yields reaching up to 87%, enantiomeric ratios ranging between 90:10 99:1. These outcomes align those achieved by homogeneous counterparts, demonstrating...