A5017443604- Radical Photochemical Reactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Advanced Photocatalysis Techniques
- Advanced biosensing and bioanalysis techniques
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
University of Amsterdam
2021-2024
Centrum Wiskunde & Informatica
2023
Abstract Unnatural amino acids, and their synthesis by the late‐stage functionalization (LSF) of peptides, play a crucial role in areas such as drug design discovery. Historically, LSF biomolecules has predominantly utilized traditional synthetic methodologies that exploit nucleophilic residues, cysteine, lysine or tyrosine. Herein, we present photocatalytic hydroarylation process targeting electrophilic residue dehydroalanine (Dha). This possesses an α , β ‐unsaturated moiety can be...
Abstract Despite their abundance in organic molecules, considerable limitations still exist synthetic methods that target the direct C−H functionalization at sp 3 ‐hybridized carbon atoms. This is even more case for light alkanes, which bear some of strongest bonds known Nature, requiring extreme activation conditions are not tolerant to most molecules. To bypass these issues, chemists rely on prefunctionalized alkyl halides or organometallic coupling partners. However, new regioselectively...
Abstract Sulfur-containing scaffolds originating from small alkyl fragments play a crucial role in various pharmaceuticals, agrochemicals, and materials. Nonetheless, their synthesis using conventional methods presents significant challenges. In this study, we introduce practical efficient approach that harnesses hydrogen atom transfer photocatalysis to activate volatile alkanes, such as isobutane, butane, propane, ethane, methane. Subsequently, these nucleophilic radicals react with SO 2...
The efficient C-4 selective modification of pyridines is a major challenge for the synthetic community. Current strategies are plagued with at least one drawback regarding functional group-tolerant electronic activation heteroarene, mild generation required alkyl radicals, regioselectivity, safety and/or scalability. Herein, we describe fast, safe and scalable flow process which allows preparation said alkylated pyridines. involves photochemical hydrogen atom transfer (HAT) event to generate...
Abstract Unnatural amino acids, and their synthesis by the late‐stage functionalization (LSF) of peptides, play a crucial role in areas such as drug design discovery. Historically, LSF biomolecules has predominantly utilized traditional synthetic methodologies that exploit nucleophilic residues, cysteine, lysine or tyrosine. Herein, we present photocatalytic hydroarylation process targeting electrophilic residue dehydroalanine (Dha). This possesses an α , β ‐unsaturated moiety can be...
Unnatural amino acids, and their synthesis via the late-stage functionalization (LSF) of peptides, play a crucial role in areas such as drug design discovery. Historically, LSF biomolecules has predominantly utilized traditional synthetic methodologies that exploit nucleophilic residues, cysteine, lysine or tyrosine. In this study, we present photocatalytic hydroarylation process targeting electrophilic residue dehydroalanine (Dha). This possesses an α,β-unsaturated moiety can be combined...
Abstract Despite their abundance in organic molecules, considerable limitations still exist synthetic methods that target the direct C−H functionalization at sp 3 ‐hybridized carbon atoms. This is even more case for light alkanes, which bear some of strongest bonds known Nature, requiring extreme activation conditions are not tolerant to most molecules. To bypass these issues, chemists rely on prefunctionalized alkyl halides or organometallic coupling partners. However, new regioselectively...
Sulfur-containing scaffolds originating from small alkyl fragments play a crucial role in various pharmaceuticals, agrochemicals, and materials. Nonetheless, their synthesis using conventional methods presents significant challenges. In this study, we introduce practical efficient approach that harnesses hydrogen atom transfer photocatalysis to activate volatile alkanes, such as isobutane, butane, propane, ethane, methane. Subsequently, these nucleophilic radicals react with SO2 yield the...
Despite their abundance in organic molecules, considerable limitations still exist synthetic methods that target the direct C-H functionalization at sp3-hybridized carbon atoms. This is even more case for light alkanes, which bear some of strongest bonds known Nature, requiring extreme activation conditions are not tolerant to most molecules. To bypass these issues, chemists rely on prefunctionalized alkyl halides or organometallic coupling partners. However, new regioselectively a variety...
Abstract Despite their abundance in organic molecules, considerable limitations still exist synthetic methods that target the direct C–H functionalization at sp 3 -hybridized carbon atoms. This is even more case for light alkanes, which bear some of strongest bonds known Nature, requiring extreme activation conditions are not tolerant to most molecules. To bypass these issues, chemists rely on prefunctionalized alkyl halides or organometallic coupling partners. However, new regioselectively...