A5091128797- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Animal Diversity and Health Studies
- Clostridium difficile and Clostridium perfringens research
- Rangeland Management and Livestock Ecology
- Transboundary Water Resource Management
- Brucella: diagnosis, epidemiology, treatment
- Gut microbiota and health
- Virology and Viral Diseases
- Paraquat toxicity studies and treatments
- Vaccine Coverage and Hesitancy
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Veterinary Equine Medical Research
- Hydropower, Displacement, Environmental Impact
- Coccidia and coccidiosis research
- Agriculture and Farm Safety
- Zoonotic diseases and public health
- Animal Behavior and Welfare Studies
- Bat Biology and Ecology Studies
- Toxoplasma gondii Research Studies
- Rabies epidemiology and control
Washington State University
2016-2018
Cornell University
2008-2014
New York State College of Agriculture & Life Sciences
2013
New York State College of Veterinary Medicine
2008-2010
Tufts University
2006
New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by protozoan parasite Toxoplasma gondii. To this end, we previously developed potent and selective inhibitor (compound 1) gondii calcium-dependent protein kinase 1 (TgCDPK1) that possesses antitoxoplasmosis activity in vitro vivo. Unfortunately, has human ether-a-go-go-related gene (hERG) inhibitory activity, associated with long Q-T syndrome, consequently presents cardiotoxicity risk. Here, describe...
Cryptosporidiosis, caused by the apicomplexan parasite Cryptosporidium parvum, is a diarrheal disease that has produced large global burden in mortality and morbidity humans livestock. There are currently no consistently effective parasite-specific pharmaceuticals available for this disease. Bumped kinase inhibitors (BKIs) specific calcium-dependent protein kinases (CDPKs) have been shown to reduce infection several parasites having medical veterinary importance, including Toxoplasma gondii,...
Cryptosporidiosis causes life-threatening diarrhea in children under the age of 5 years and prolonged immunodeficient people, especially AIDS patients. The standard care, nitazoxanide, is modestly effective ineffective immunocompromised individuals. In addition to need for new drugs, better knowledge drug properties that drive vivo efficacy needed facilitate development. We report identification a piperazine-based lead compound Cryptosporidium development, MMV665917, pharmacodynamic method...
The gut microbiome community structure and development are associated with several health outcomes in young children. To determine the household influences of structure, we assessed microbial sharing within households western Kenya by sequencing 16S rRNA libraries fecal samples from children cattle, cloacal swabs chickens, surfaces. Among 156 studied, same significantly shared their each other, although did not find significant across host species or Higher diversity among was lower wealth...
Diarrhoeal disease caused by Cryptosporidium is a major cause of morbidity and mortality in young malnourished children from low- middle-income countries, with no vaccine or effective treatment. Here we describe the discovery EDI048, PI(4)K inhibitor, designed to be active at infection site gastrointestinal tract undergo rapid metabolism liver. By using mutational analysis crystal structure, show that EDI048 binds highly conserved amino acid residues ATP-binding site. orally efficacious an...
Evaluation of dairy calf feces is often used in research and for clinical decision making to assess severity diarrhea. However, this has not been validated agreement between dry matter content observed fecal consistency. Therefore, a comparison consistency score percent Cryptosporidium parvum oocyst shedding was performed the accuracy observational scoring as measure diarrhea its association with number oocysts shed. Fecal samples from 20 calves experimentally infected C. were collected...
Medetomidine (0.03 mg/kg) and medetomidine/ketamine (0.05/5.0 0.025/2.5 mg/kg), administered by intravenous injection, were evaluated for short-term immobilization of wild-caught variable flying foxes (Pteropus hypomelanus). alone produced incomplete chemical restraint a stressful, prolonged induction. Both ketamine/medetomidine doses smooth induction complete immobilization. The combined dose mg/kg rapid (232±224 sec) with minimal struggling vocalization, effective period, tended to lead...
Diarrhea is the second leading cause of death in children < 5 years globally and parasite genus Cryptosporidium a that diarrhea. The global disease burden attributable to cryptosporidiosis substantial only approved chemotherapeutic, nitazoxanide, has poor efficacy HIV positive children. Chemotherapeutic development dependent on calf model cryptosporidiosis, which best approximation human disease. However, not consistently applied across research studies. Data collection commonly occurs using...
Aim: To determine the impact of storage temperature and sample volume on milk culture success under a simulated field setting. Study Design: Prospective cohort study.
Background Humans and animals living in close proximity may share microbiome constituents at the household level because of daily domestic contact. Such sharing could affect enteric metabolic functions gut humans livestock such households. We sought to characterise children, cattle, chickens, environmental surfaces within households western Kenya determine degree sharing.
Abstract Cryptosporidium parvum is a zoonotic apicomplexa-protozoan pathogen that causes gastroenteritis and diarrhoea in mammals worldwide. The organism transmitted by ingestion of oocysts, which are shed faeces, completes its lifecycle single host.^1^ C. ubiquitous on dairy operations worldwide one the leading calves these farms.^2,3^ Here, for first time, we describe antibody response large group cows to recombinant oocyst surface protein (rCP15/60) vaccine fed rCP15/60-immune colostrum...
Cryptosporidium is a zoonotic protozoan that most often diagnosed in association with diarrhea one to three week old dairy calves. There are neither consistently effective nor approved antimicrobials for treatment animals. The objective of this study was test nitazoxanide (NTZ) as cryptosporidiosis experimentally challenged