A5013161783- Bladder and Urothelial Cancer Treatments
- Acute Ischemic Stroke Management
- Pharmaceutical Practices and Patient Outcomes
- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Protein Kinase Regulation and GTPase Signaling
- Monoclonal and Polyclonal Antibodies Research
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Medication Adherence and Compliance
- Parasitic Infections and Diagnostics
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Intensive Care Unit Cognitive Disorders
- Glycosylation and Glycoproteins Research
- Clostridium difficile and Clostridium perfringens research
- Blood Pressure and Hypertension Studies
- Patient Safety and Medication Errors
- Healthcare Systems and Practices
- Cytokine Signaling Pathways and Interactions
- Vascular Malformations Diagnosis and Treatment
- Antibiotic Use and Resistance
Novartis (United States)
2007-2024
Universiti Teknologi MARA
2011-2024
University of Liverpool
2022-2023
Queen Mary University of London
2022
Genomics Institute of the Novartis Research Foundation
2021
National University of Malaysia
2020
Universiti Sains Malaysia
2007-2013
Brighton and Sussex Medical School
2013
New York University
2009
Novartis (France)
2008
Many of the interstitial lung diseases represent a diagnostic and therapeutic challenge because their clinical even histologic features are often nonspecific. Likewise, transcriptional signatures most them unknown.To compare gene expression patterns from patients with idiopathic pulmonary fibrosis (IPF) hypersensitivity pneumonitis (HP), nonspecific pneumonia (NSIP) using custom oligonucleotide microarrays.We profiled biopsies 15 IPF, 12 HP, eight NSIP. Labeled complementary ribonucleic acid...
Fentanyl was administered to 21 patients using a computer-controlled infusion pump (CCIP) based on pharmacokinetic model. Eleven of the were dosed according pharmacokinetics described by McClain and Hug, ten Scott Stanski. The authors measured difference between arterial fentanyl concentrations predicted CCIP for each parameter set. median absolute performance error (MDAPE) in Hug's parameters 61%, MDAPE Stanski's 33%. population these analyzed pooled data technique. this showed smaller...
Millions who live in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections, which cause Chagas disease human African trypanosomiasis (HAT). Improved HAT treatments available, but therapies rely on two nitroheterocycles, suffer from lengthy drug regimens safety concerns that frequent treatment discontinuation. We performed phenotypic screening against trypanosomes identified a class cyanotriazoles (CTs) with potent trypanocidal activity both vitro mouse models HAT....
In Rat-1 fibroblasts nonmitogenic doses of lysophosphatidic acid (LPA) stimulate a transient activation mitogen-activated protein kinase (MAPK), whereas mitogenic elicit sustained response. This phase MAPK regulates cell fate decisions such as proliferation or differentiation, presumably by inducing program gene expression which is not observed in response to activation. We have examined the members AP-1 transcription factor complex stimulation with different LPA. c-Fos, c-Jun, and JunB are...
Abstract Purpose: Cancer of the urinary bladder is a common malignant disease in western countries. The majority patients presents with superficial tumors high recurrence frequency, minor fraction these experience progression to muscle invasive stage. No clinical useful molecular markers exist identify showing later progression. purpose this study was using full-genome expression analysis. Experimental Design: We did analysis (59,619 genes and expressed sequence tags) from 29 cancer (13...
To determine the maximum tolerated dose (MTD) dose-limiting toxicity, and pharmacokinetic pharmacodynamic profile of TKI258 (formerly CHIR-258).A phase I escalating trial in patients with advanced solid tumors was performed. Treatment initially as single daily doses on an intermittent 7-day on/7-day off schedule. Following a protocol amendment, second schedule comprised, during cycle 1, treatment followed by 14 days continuous dosing; subsequent cycles comprised 28 dosing. Pharmacokinetics...
B-cell chronic lymphocytic leukemia (B-CLL) is a lymphoproliferative disorder characterized by the surface expression of CD20, CD5 antigens, as well receptor CD40. Activation CD40 its ligand (CD40L) induces proliferation and rescues cells from spontaneous chemotherapy-induced apoptosis. activation also secretion cytokines, such IL-6, IL-10, TNF-alpha, IL-8, GM-CSF, which are involved in tumor cell survival, migration, interaction with microenvironment. Here we demonstrate that primary B-CLL...
The c-myb protooncogene encodes a highly conserved transcription factor that functions as both an activator and repressor of transcription. v-myb oncogenes E26 leukemia virus avian myeloblastosis encode proteins are truncated at the amino carboxyl terminus, deleting portions c-Myb DNA-binding negative regulatory domains. This has led to speculation deleted regions contain important sequences. We previously reported 42-kDa mitogen-activated protein kinase (p42mapk) phosphorylates chicken...
Micro-RNAs are a group of small noncoding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression mature micro-RNAs human cancers. We characterized the alteration miR-29b ovarian serous carcinoma. was analyzed using quantitative stem-loop reverse transcriptase polymerase chain reaction on set 50 formalin-fixed, paraffin-embedded carcinoma samples. Protein p53, estrogen receptor, progesterone epidermal growth factor receptor 2, Ki-67, and insulinlike 1...
Diarrhoeal disease caused by Cryptosporidium is a major cause of morbidity and mortality in young malnourished children from low- middle-income countries, with no vaccine or effective treatment. Here we describe the discovery EDI048, PI(4)K inhibitor, designed to be active at infection site gastrointestinal tract undergo rapid metabolism liver. By using mutational analysis crystal structure, show that EDI048 binds highly conserved amino acid residues ATP-binding site. orally efficacious an...
The c-myb protooncogene encodes a highly conserved 75-89-kDa transcription factor that contains three functional domains, an amino-terminal DNA binding domain (DBD), central acidic transactivation domain, and carboxyl-terminal negative regulatory (NRD). Two acute transforming retroviruses, avian myeloblastosis virus the E26 leukemia virus, transduced portions of encode Myb proteins are truncated in both DBD NRD. Several potential sites for phosphorylation by proline-directed serine/threonine...
Ras-activated signal transduction pathways are implicated in the control of cell proliferation, differentiation, apoptosis, and tumorigenesis, but molecular mechanisms mediating these diverse functions have yet to be fully elucidated. Conditionally active forms Raf, v-Src, MEK1 were used identify changes gene expression that participate oncogenic transformation, as well normal growth control. Activation led induced c-Myc cyclin D1. Induction mRNA by Raf was an immediate-early response,...
Positron emission tomography (PET) imaging has become a useful tool for assessing early biologic response to cancer therapy and may be particularly in the development of new therapeutics. RAF265, novel B-Raf/vascular endothelial growth factor receptor-2 inhibitor, was evaluated preclinical setting its ability inhibit uptake PET tracers A375M(B-Raf(V600E)) human melanoma cell line. RAF265 inhibited 2-deoxy-2-[(18)F]fluoro-d-glucose (FDG) accumulation culture at 28 hours dose-dependent manner....
What is known and Objectives Pharmacists have the knowledge regarding optimal use of medications ability to influence physician prescribing. Successful interventions by a pharmacist implement cardioprotective coronary artery disease patient's regimen would not only improve quality care but may also increase his or her likelihood survival. Therefore, aim this study was (i) evaluate effectiveness initiated in increasing prescription rates acute syndrome (ACS) secondary prevention...
No AccessJournal of UrologyAdult urology1 Apr 2006A Molecular Signature in Superficial Bladder Carcinoma Predicts Clinical Outcome L. Dyrskjot, K. Zieger, M. Kruhoffer, T. Thykjaer, J.L. Jensen, H. Primdahl, N. Aziz, Marcussen, Moller, and T.F. Orntoft DyrskjotL. Dyrskjot More articles by this author , ZiegerK. Zieger KruhofferM. Kruhoffer ThykjaerT. Thykjaer JensenJ.L. Jensen PrimdahlH. Primdahl AzizN. Aziz MarcussenN. Marcussen MollerK. Moller OrntoftT.F. View All Author...
The c-Myb protein is a transcription factor with an apparent but poorly defined role in hematopoietic cell growth and differentiation. DNA binding several transcriptional regulatory domains of the have been by transient transfections into nonhematopoietic lines. Although relationship between these transformation has studied, little known about function during maturation. Up-regulation stably transfected c-myb murine erythroleukemia (MEL) cells blocks terminal differentiation when MEL are...
To report a case of early-decompensated liver cirrhosis secondary to discontinuation penicillamine therapy in patient with Wilson's disease.A 33-year-old Chinese female was diagnosed disease, for which 250 mg p.o. once daily prescribed. However, the developed intolerance and discontinued without alternative treatment. Five months later, she decompensated hepatic encephalopathy. Eventually, died because complications sepsis failure.Chelating agent is mainstay treatment an inherited disorder...
Cryptosporidiosis is a leading cause of moderate-to-severe diarrhea in low- and middle-income countries, responsible for high mortality children younger than two years age, it also strongly associated with childhood malnutrition growth stunting. There no vaccine cryptosporidiosis existing therapeutic options are suboptimal to prevent morbidity young children. Recently, novel agents have been discovered through high-throughput phenotypic target-based screening strategies, repurposing malaria...