Ischemia is characterized by oxidative stress and changes in the antioxidant defense system. Our recent vitro study showed that 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride protects cortical astrocytes against stress. In current study, we examined effects of on ischemia-induced neuronal damage a gerbil ischemia/reperfusion models. Extensive death hippocampal CA1 area was observed 4 days after ischemia/reperfusion. Intraperitoneal injection (0.3 mg/kg body weight) significantly...

Although CT has been used widely, the role of preoperative findings including other factors in tympanoplasty not elucidated comprehensively.To evaluate relationship with and audiological results type 1 tympanoplasty.A cohort consecutive 175 patients was enrolled. Addition mastoidectomy based on presence soft tissue antrum CT. Postoperative air-bone gap (ABG) reperforation rate were analyzed.Positive found 52 (29.7%) showed larger ABG than negative group. Successful closure (≤20 dB) obtained...

Human glutamate dehydrogenase isozymes (hGDH1 and hGDH2) have been known to be inhibited by palmitoyl-CoA with a high affinity.In this study, we performed the cassette mutagenesis at six different Cys residues (Cys59, Cys93, Cys119, Cys201, Cys274, Cys323) identify binding sites within hGDH2.Four cysteine positions of C59, C93, C201, or C274 may involved, least in part, inhibition hGDH2 palmitoyl-CoA.There was biphasic relationship, depending on levels palmitoyl-CoA, between loss enzyme...

Patulous eustachian tube (ET) has been characterised by the visualisation of full-length ET on computed tomography (CT) results. We wanted to investigate changes visualised lengths age in supine and sitting positions.Retrospective study.Tertiary care academic referral centre.One hundred subjects who underwent cone beam CT (CBCT) a position conventional for non-otitis-related or dental complaints.Visualised from nasopharyngeal orifice measured different positions ages.Subjects did not show...

Background: The accurate detection of distant metastases can facilitate appropriate treatment planning for patients with recurrent head and neck squamous cell carcinoma (HNSCC). Objectives: We evaluated the role 18F-FDG PET/CT metastasis diagnosis survival prediction in HNSCC. Materials methods: This study included 95 consecutive HNSCC salvage treatments. McNemar's test was used to compare at recurrence using contrast-enhanced chest CT, bone scintigraphy. Results: Thirty-two (34%) had...

This study aimed to evaluate long-term changes after balloon dilation of the Eustachian tube (BDET) in chronic otitis media (COM) patients with (ET) dysfunction that persisted tympanomastoidectomy (TM).We retrospectively reviewed medical records consecutive who were diagnosed COM and ET underwent TM at our tertiary hospital from 2016 2017. The tympanic membrane status, presence a ventilation tube, ability perform Valsalva maneuver, audiologic analyzed.This included 20 (with 21 ears) but...

Background Optimizing the educational experience of trainees in operating room is important; however, ear anatomy and otologic surgery are challenging for to grasp. Viewing surgeries often involves limitations related video quality, such as visual disturbances instability.

To investigate the long-term educational and occupational status of prelingually bilateral deaf children who received a cochlear implant (CI) before age 7, to identify factors that influence these outcomes.Retrospective chart review.Single tertiary care center.Seventy-one underwent CI surgery from 2000 2007 were included. The latest education occupation word recognition score (WRS) analyzed.The mean at time current was 3.9 22.4 years. showed negative correlation with WRS. All subjects had...

When vestibular schwannoma originates from the segment within labyrinth of vestibulocochlear nerve, it is termed intralabyrinthine (ILS). As most cases are presented with profound sensorineural hearing loss on affected side, for auditory rehabilitation, cochlear implantation can be considered simultaneously as tumor removal. Successful results were reported in patients ILS even after partial resection mass. In this study, we report two unilateral deafness. one patient, a mass found basal...

Background and Objectives Stapes surgery has been widely used to improve the conductive hearing loss caused by stapedial fixation. The purpose of this study is evaluate causes fixation using audiological results 100 stapes surgeries.Subjects Method We reviewed medical records consecutive surgeries between June 2011 December 2022. A total ears from 86 patients were included patient age ranged 6 80 years. Hearing improvements pure-tone thresholds defined as successful when air-bone gap (ABG)...

The Ex-Utero Intrapartum Treatment (EXIT) is a procedure that secures the airway in fetus with upper obstruction. Congenital high obstruction syndrome (CHAOS) blockage of fetal trachea or larynx due to narrowing (stenosis), web-like membrane, even an area missing (atresia). If it was not adequately diagnosed and managed prenatal evaluation, infant would survive after birth. We present case CHAOS, which treated successfully by EXIT during delivery. (J Clinical Otolaryngol 2017;28:297-301)

Objectives: Video head impulse test (vHIT) can evaluate function of the vestibuloocular reflex for high frequency range rotation. We aimed to characterize abnormal patterns canal dysfunction by vHIT in vestibular migraine (VM) and relationship between presence symptomatic improvement.Methods: Eighty-seven patients with VM were included. Abnormality at initial examination was determined gain degrees corrective saccades each side. The improvement (no need preventive medication) after...

Objectives Pathophysiology of vestibular migraine (VM) is still controversial. Vertigo may act as a trigger for or there might other mechanisms which cause and dizziness. VM patients have headaches dizziness simultaneously sequentially. Therefore, we hypothesized that the sequence symptoms suggest different compared results function tests (VFTs) according to chronological order headache vertigo. Methods Forty-two with were included. They divided into three subgroups orders vertigo, VFTs...