A5055331894- Rheumatoid Arthritis Research and Therapies
- Streptococcal Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Blood transfusion and management
- Systemic Lupus Erythematosus Research
- Neonatal and Maternal Infections
- Effects of Radiation Exposure
- Hematological disorders and diagnostics
- Sepsis Diagnosis and Treatment
- Bone Metabolism and Diseases
- Toxin Mechanisms and Immunotoxins
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Spondyloarthritis Studies and Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Renal Transplantation Outcomes and Treatments
- Immune Response and Inflammation
- Blood donation and transfusion practices
- Orthopedic Infections and Treatments
- Immunotoxicology and immune responses
- Liver Disease Diagnosis and Treatment
- Celiac Disease Research and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Surgical site infection prevention
Teikyo University
2005-2022
The University of Tokyo
2009
National Sagamihara Hospital
2009
National Hospital Organization
2009
Center for Rheumatology
2009
Case Western Reserve University
1998-1999
National Institute of Health Sciences
1989
Mesenchymal progenitor cells provide a source of for the repair musculoskeletal tissue. However, in vitro models are needed to study mechanisms differentiation cells. This demonstrated successful induction chondrogenesis with human bone-marrow-derived osteochondral reliable and reproducible culture system. Human bone marrow was removed fractionated, adherent cell cultures were established. The then passaged into an aggregate system serum-free medium. Initially, aggregates contained type-I...
Objective To assess the chondrogenic potential of cells within synovium. Methods Explants synovium taken from various sites in joint were embedded agarose and cultured with transforming growth factor β1 (TGFβ1) to their potential. Isolated synovial also tested for by culturing them as aggregates a chemically defined medium TGFβ1. Cartilage formation was determined histologic staining immunohistochemistry. The osteochondral isolated assessed after subcutaneous implantation cells, loaded into...
Intestinal bacterial compositions of rheumatoid arthritis (RA) patients have been reported to be different from those healthy people. Dysbiosis, imbalance the microbiota, is widely known cause gut barrier damage, resulting in an influx bacteria and their substances into host bloodstreams animal studies. However, few studies investigated effect on pathophysiology RA. In this study, eighty-seven active RA who had inadequate responses conventional synthetic disease-modifying antirheumatic drugs...
We examined the usefulness of neutrophil CD64 expression in detecting local musculoskeletal infection and impact antibiotics on its expression. Of 141 patients suspected infection, 46 were confirmed by microbiological culture to be infected 95 had excluded. The median count with localised was 2230 molecules per cell (interquartile range (IQR) 918 4592) that without 937 (IQR 648 1309) (p < 0.001). level correlated CRP but not those (r = 0.59, p 0.01). Receiver operator characteristic curve...
Osteopetrosis is an inherited disorder characterized by reduced bone resorption. We here report a rare case of osteopetrosis associated with rheumatoid arthritis. The patient was diagnosed as autosomal dominant type II in his youth and developed arthritis at 42 years age. In spite the severe inflammation rapid progression cartilage destruction, erosion slow this patient.
Neutrophil CD64 has been reported to be a sensitive and specific infection marker. Its measurement is thus considered useful in early diagnosis of post-operative periprosthetic infection. However, even its normal sequential changes after non-infectious total joint arthroplasty have remained ambiguous. Accordingly, we analyzed 2-week neutrophil expression order clarify postoperative kinetics. From 41 patients who underwent primary arthroplasties, peripheral blood samples were obtained at 1...
Journal Article Rheumatoid arthritis associated with osteopetrosis Get access Yuho Kadono, Kadono Department of Orthopaedic Surgery, Faculty Medicine, The University Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Search for other works by this author on: Oxford Academic Google Scholar Sakae Tanaka, Tanaka Correspondence to: e-mail: TANAKAS-ORT@h.u-tokyo.ac.jp Jinju Nishino, Nishino Teikyo School 2-11-1 Kaga, Itabashi-ku, 173-8605, Keita Nishimura, Nishimura Ichiro Nakamura, Nakamura...
The purpose of this study was to describe the prevalence total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment a large observational cohort Japan. A 5,177 RA were studied for TJA, who enrolled NinJa database during fiscal year 2006. cases 2,695 with more than ten years disease duration extracted and subjected further analysis. TJA increased accordance duration, markedly after years. Among 1,431 TJAs performed 645 (24.6%)...
The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected 31 were confirmed 68 not. level with infection significantly higher than those without [4,193 ± 1,132 vs. 1,017 59 molecules/cell (mean standard deviation); p < 0.001]. area under the curve calculated by receiver operating characteristic analysis larger that C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or...
The purpose of this study was to describe the prevalence total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment a large observational cohort Japan. A 5,177 RA were studied for TJA, who enrolled NinJa database during fiscal year 2006. cases 2,695 with more than ten years disease duration extracted and subjected further analysis. TJA increased accordance duration, markedly after years. Among 1,431 TJAs performed 645 (24.6%)...
Journal Article Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis Get access Toru Doi, Doi Department of Orthopaedic Surgery, Tokyo Metropolitan Geriatric Hospital Institute Gerontology, 35-2 Sakae-cho, Itabashi-ku, 173-0015, Japan Search other works by this author on: Oxford Academic Google Scholar Tsuyoshi Miyazaki, Miyazaki Jinju Nishino, Nishino Clinic Orthopedics Rheumatology, 2-9-15 Nishigaoka, Kita-ku, 115-0056, Sakae Tanaka, Tanaka...
To determine the efficacy and safety of single-dose mizoribine (MZR) for patients with rheumatoid arthritis (RA), a 6-month, single-arm, open-label, prospective observation study was performed. In who had been taking MZR at 100–150 mg/day in 2–3 divided portions continuously least 3 months, shown lack clinical response, or escape (defined as response time switching, even if some form before that), multiple-dose administration switched to without changing total daily dose. Efficacy assessed...
This study aimed to clarify whether plasma acrolein level actually increases in rheumatoid arthritis (RA) patients, and elucidate any relationship exists between the levels RA background variables. Plasma of protein-conjugated (PC-Acro) 84 patients (RA group) 298 normal individuals (Control were measured by enzyme-linked immunosorbent assay procedures. The data statistically analyzed with Wilcoxon rank-sum test, multiple logistic regression analyses Spearman’s rank correlation coefficient....
To determine the efficacy and safety of single-dose mizoribine (MZR) for patients with rheumatoid arthritis (RA), a 6-month, single-arm, open-label, prospective observation study was performed. In who had been taking MZR at 100–150 mg/day in 2–3 divided portions continuously least 3 months, shown lack clinical response, or escape (defined as response time switching, even if some form before that), multiple-dose administration switched to without changing total daily dose. Efficacy assessed...
No change of infliximab levels in stored blood for preoperative autologous donation: a preliminary report Get access Keita Nishimura, Nishimura Department Orthopaedic Surgery, Teikyo University School Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan Correspondence to: Tel. +81-3-3964-4097; Fax +81-3-5375-6864 e-mail: keitan@med.teikyo-u.ac.jp Search other works by this author on: Oxford Academic Google Scholar Nobuhiro Wakimoto, Wakimoto Jun Sasahara, Sasahara Chiaki Yanagisawa,...
Rheumatoid arthritis (RA) patients requiring total joint arthroplasties under administration of infliximab, which may remain in donated blood if preoperative autologous donation (PABD) is undertaken for the surgery, risk infection. We clarified infliximab hemokinetics stored such patients. A 20-ml sample was obtained from each ten RA receiving at just after and 2 4 weeks following mixed with 2.8 ml citrate-phosphate-dextrose-adenine (CPDA-1) 4-6 degrees C. Plasma levels were measured...