A5000598448- Spinal Cord Injury Research
- Heterotopic Ossification and Related Conditions
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Medical Practices and Rehabilitation
- Stroke Rehabilitation and Recovery
- Spine and Intervertebral Disc Pathology
- Medical and Health Sciences Research
- Trauma Management and Diagnosis
- Trauma and Emergency Care Studies
- Spinal Hematomas and Complications
- Criminal Law and Policy
- Pelvic and Acetabular Injuries
- Cerebral Palsy and Movement Disorders
- Pleural and Pulmonary Diseases
- Diabetic Foot Ulcer Assessment and Management
- Spondyloarthritis Studies and Treatments
- Respiratory Support and Mechanisms
- Spinal Dysraphism and Malformations
- German Literature and Culture Studies
- Infectious Diseases and Tuberculosis
- Streptococcal Infections and Treatments
- Prosthetics and Rehabilitation Robotics
- Mechanical Circulatory Support Devices
- Nerve Injury and Rehabilitation
BG University Hospital Bergmannsheil Bochum
2012-2025
Ruhr University Bochum
2009-2025
Spinal Injuries Center
2014-2017
New Energy and Industrial Technology Development Organization
2016
LWL-Universitätsklinikum Bochum
2013
University Hospitals of the Ruhr-University of Bochum
2013
Medical University of Vienna
2003
Background. Neutralization of central nervous system neurite growth inhibitory factors, for example, Nogo-A, is a promising approach to improving recovery following spinal cord injury (SCI). In animal SCI models, intrathecal delivery anti-Nogo-A antibodies promoted regenerative and functional recovery. Objective. This first-in-man study assessed the feasibility, safety, tolerability, pharmacokinetics, preliminary efficacy human antibody ATI355 administration in patients with acute, complete...
Reorganization in the sensorimotor cortex accompanied by increased excitability and enlarged body representations is a consequence of spinal cord injury (SCI). Robotic-assisted bodyweight supported treadmill training (BWSTT) was hypothesized to induce reorganization improve walking function.
Chronic neuropathic pain (CNP) is a common condition associated with spinal cord injury (SCI) and has been reported to be severe, disabling often treatment-resistant therefore remains clinical challenge for the attending physicians. The treatment usually includes pharmacological and/or nonpharmacological approaches. Body weight supported treadmill training (BWSTT) locomotion driven gait orthosis (DGO) have evolved over last decades are now considered an established part in rehabilitation of...
Objective Age and lesion level are believed to represent outcome predictors in rehabilitation of patients with chronic spinal cord injury (SCI). The Hybrid Assistive Limb (HAL) exoskeleton enables perform a voluntary controlled gait pattern via an electromyography-triggered neuromuscular feedback system, has been introduced as temporary training tool SCI. aim this prospective pre- postintervention study was examine functional outcomes function age incomplete SCI (iSCI) or complete (cSCI)...
Case-control study.We designed a case-control study to analyze the risk factors associated with development of heterotopic ossification (HO) in patients traumatic spinal cord injury.Patients injury have high developing HO, although exact etiopathogenesis is still unknown. Several are known be potential factors. However, we not aware any large clinical studies evaluating for HO.Patients who were treated our hospital, and subsequently developed identified by querying electronic database at...
Abstract Study design Clinical prospective study. Objectives To histologically examine puncture biopsies of early neurogenic heterotopic ossification (NHO) in spinal cord injured individuals. Setting University Bochum, Germany. Methods After acute trauma, participants underwent a sonographic examination the hip joints and routine laboratory examination. Magnetic resonance imaging (MRI) or computed tomography (CT) pelvis was performed if there were clinical signs NHO evidence edema and/or...
Longitudinal prospective study.Whether 1-year HAL-BWSTT of chronic spinal cord injured patients can improve independent ambulated mobility further as a function training frequency, after an initial 3-month period.Eight with SCI were enrolled. They initially received full standard physical therapy and neurorehabilitation in the acute/subacute posttrauma phase. During this trial, all first underwent daily (5 per week) for 12 weeks. Subsequently, these performed 40-week session frequency either...
Retrospective chart review.The aim of this study was to analyze the correlation between necrotizing fasciitis (NF) and pressure ulcers, as well mortality, complication rate, in patients with spinal cord injury (SCI).Pressure ulcers represent a challenging problem, especially immobilized patients. Necrotizing soft tissue infections arising from decubitus SCIs have been reported.Twenty-five SCI NF treated April 2000 December 2009 were included study. All analyzed regard number surgical...
Retrospective analysis of vertebral fractures in patients with ankylosing spondylitis (AS) for the evaluation associations mortality, concurrent neurological deficits, and other complications.Image (conventional radiographs, CT, MRI) was applied to all AS admitted between 1997 2007 due determine fracture location classification. Patient characteristics, trauma mechanism, symptoms, complications were documented.66 (54 male, age 64 +/- 11 years) enrolled study. 74 % suffered from minor trauma....
Study Design. A case-control study; clinical prediction rule. Objective. The aim of this study was to construct and internally validate a rule identify patients at high risk developing heterotopic ossification (HO) after spinal cord injury (SCI). Summary Background Data. HO SCI can lead loss joint mobility, function, peripheral nerve entrapment, pressure sores. is usually diagnosed on the basis symptoms, as no laboratory tests are yet available with early formation. Risk factors include...
Heterotopic ossification (HO) is a common concominant condition in patients with traumatic spinal cord injury (SCI). In this context, we report on heterotopic causing infection like symptoms as first manifestation of HO subsequent to SCI.The objective the study was analyse possible ``early-indicator symptoms'' suffering from following SCI special focus elevated serum CRP, CK and body temperature.All eligible treated between January 2004 December 2013 because have been enrolled retrospective...